Assessment of biochemical and hematological parameters related to aging in people living with HIV
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2024.214970Palabras clave:
Aging, HIV, Biochemical marker, Blood cell count, BiomarkersResumen
Background: HIV infection is a serious public health problem worldwide. The number of elderly people living with HIV has increased rapidly, due to the success of antiretroviral therapy and lifestyle changes. However, the chronic inflammation caused by HIV and the effects of antiretroviral therapy have been associated with the premature aging of these individuals. To date, there is no consensus on the age at which an individual with HIV is considered elderly. In this context, the present study aims to evaluate, through biomarkers, aging in people living with HIV. Method: This is a cross-sectional study developed with people living with HIV, attended at the Specialized Care Service of Divinópolis in the state of Minas Gerais, from October 2019 to March 2021. For comparison, a non-HIV group, was selected from the national health survey database. Patients were divided into age groups: 18 to 49, 50 to 59, and over 60 years for some analysis, other analyses were carried out with age groups: over 50 years and over 60 years. The groups were compared in terms of biochemical and hematological variables with each other and with the components of the non-HIV group. Results: When analyzing the renal function of the HIV and non-HIV groups of over 60 years old, no differences were found between the groups. When comparing the metabolic profile of the HIV group aged 50 to 59 years and those aged over 60 years, they also did not differ. Finally, when analyzing hematological data, different patterns were shown. For the red blood cell count, the group from 50 to 59 years old was the same as the group over 60 years old; in relation to hematocrit, the group from 50 to 59 years old was the same as the group from 18 to 49 years old. Conclusions: This study demonstrates that for renal function and hematocrit, the age cutoff for an individual with HIV to be considered elderly would be 60 years of age or older. In contrast, for the metabolic profile and for the red blood cell count, the ideal age cutoff would be 50 years or older. These results may be of great importance to guide dose adjustment and choice of drugs for people living with HIV at older ages, aiming at better therapeutic control.
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Derechos de autor 2024 Gilcelia Correia Santos Bernardes, Ana Paula Nogueira Godoi, Thaís Lorenna Souza Sales, Leilismara Sousa Nogueira, Melina Barros-Pinheiro, Cristina Sanches, Eduardo Sergio da Silva
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
