The contribution of arterial versus venous vascular permeability in peritoneal fluid formation

Authors

  • Igor Ivanecky University of Toronto; The Hospital for Sick Children
  • Jaques Belik University of Toronto; The Hospital for Sick Children

DOI:

https://doi.org/10.7322/jhgd.19984

Keywords:

capillary permeability, muscle smooth, vascular endothelium, vascular, Bradykinin, Cardiovascular System

Abstract

OBJECTIVES: peritoneal fluid accumulation is a common finding in many children with abdominal disorders and its generation secondary to increased vascular permeability. The contribution of the arterial versus venous circulation to edema formation and peritoneal fluid accumulation is poorly understood. Studies conducted in vivo more than two decades ago suggested that the postcapillary venules were more important than the arterial vessels in the process of edema formation. The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. METHOD: mesenteric arteries (MA) and veins (MV) were mounted on glass cannulas, intravascularly filled with fluorescent dextran and incrementally pressurized above their in vivo physiological values. Vascular permeability to dextran was determined at 100, 200 and 300 % of physiological pressures. RESULT: vascular permeability was present at all measurements for both vessels and its magnitude directly proportional to the intravascular pressure. Bradykinin (10-5 M) significantly increased permeability in the MV but not in the MA. CONCLUSION: the abdominal fluid accumulation related to bowel inflammatory disease is more likely to be secondary to venous, as opposed to arterial vascular leakage.

Downloads

Download data is not yet available.

References

Bill A, Linder J. Sympathetic control of cerebral blood flow in acute arterial hypertension. Acta Physiol Scand; 96:114-21;1976.

Medeiros R, Cabrini DA, Ferreira J, Fernandes ES, Mori MA, Pesquero JB, et al. Bradykinin B1 receptor expression induced by tissue damage in the rat portal vein: a critical role for mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways. Circ Res; 94:1375-82;2004.

Regoli D, Marceau F, Barabe J. De novoformation of vascular receptors for bradykinin. Can J Physiol Pharmacol. 56:674-7;1978.

Adamson RH, Ly JC, Fernandez-Miyakawa M, Ochi S, Sakurai J, Uzal F. et al. Clostridium perfringens epsilon toxin in-creases permeability of single perfused micro vessels of rat mesentery. Infect Immun; 73:4879-87;2005.

Baldwin AL, Thurston G, Al NH. Inhibit-on of nitric oxide synthesis increases venular permeability and alters endothelial actin cytoskeleton. Am J Physiol. 274:H1776-H1784;1998.

Feletou M, Bonnardel E, Canet E. Bradykinin and changes in microvascular permeability in the hamster cheek pouch: role of nitric oxide. Br J Pharmacol; 118:1371-6;1996.

Svensjo E, Arfors KE. Dimensions of postcapillary venules sensitive to brady kininand histamine-induced leakage of macro-molecules. Ups J Med Sci; 84:47-60;1979.

Cipolla MJ, Vitullo L, De Lance N, Hammer E. The cerebral endothelium during pregnancy: a potential role in the development of eclampsia. Endothelium; 12:5-9; 2005.

Baldwin A.L. Modified hemoglobins produce venular interned thelial gaps and albumin leakage in the rat mesentery. Am JPhysiol; 277:H650-H659;1999.

Mayhan WG. Role of nitric oxide in modulating permeability of hamster cheek pouch in response to adenosine 5'-diphos-phate and brady kinin. Inflammation;16:295-305;1992.

Koyama S, Rennard SI, Robbins RA. Bradykinin stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. Am J Physiol;269:L38-L44;1995.

Satoh K, Yoshida H, Imaizumi TA, Koyama M, Takamatsu S. Production of plate-let-activating factor by porcine brain microvascular endothelial cells in culture.Thromb Haemos; 74:1335-9;1995.

Shigematsu S, Ishida S, Gute DC, Korthuis RJ. Concentration-dependent effects of bradykinin on leukocyte recruitment and venular hemodynamics in rat mesentery. Am J Physiol; 277:H152-H160;1999.

Dull RO, Garcia JG. Leukocyte-inducedmicrovascular permeability: how contract-tile tweaks lead to leaks. Circ Res;90:1143-4;2002.

Bucci M, Roviezzo F, Posadas I, Yu J, Parente L, Sessa WC. et al. Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo. Proc Natl Acad Sci USA; 102:904-8;2005.

Downloads

Published

2010-12-01

Issue

Vol. 20 No. 3 (2010)

Section

Original Research

License

CODE OF CONDUCT FOR JOURNAL  PUBLISHERS

 

Publishers who are Committee on Publication Ethics members and who support COPE membership for journal editors should:

 

Publishers should:

 

  • Define the relationship between publisher, editor and other parties in a contract
  • Respect privacy (for example, for research participants, for authors, for peer reviewers)
  • Protect intellectual property and copyright
  • Foster editorial independence

 

Publishers should work with journal editors to:

 

  • Set journal policies appropriately and aim to meet those policies, particularly with respect to:

–         Editorial  independence

–         Research ethics, including confidentiality, consent, and the special requirements for human and animal research

–         Authorship

–         Transparency and integrity (for example, conflicts of interest, research funding, reporting standards

–         Peer review and the role of the editorial team beyond that of the journal editor

–         Appeals and complaints

  • Communicate journal policies (for example, to authors, readers, peer reviewers)
  • Review journal policies periodically, particularly with respect to new recommendations from the COPE
  • Code of Conduct for Editors and the COPE Best Practice Guidelines
  • Maintain the integrity of the academic record
  • Assist the parties (for example, institutions, grant funders, governing bodies) responsible for the investigation of suspected research and publication misconduct and, where possible, facilitate in the resolution of these cases
  • Publish corrections, clarifications, and retractions
  • Publish content on a timely basis