The contribution of arterial versus venous vascular permeability in peritoneal fluid formation

Autores

  • Igor Ivanecky University of Toronto; The Hospital for Sick Children
  • Jaques Belik University of Toronto; The Hospital for Sick Children

DOI:

https://doi.org/10.7322/jhgd.19984

Palavras-chave:

Permeabilidade capilar, músculo liso, vascular, Eedotélio vascular, Bradicinina, sistema cardiovascular

Resumo

OBJETIVO: o acúmulo de líquido peritoneal é um achado comum em muitas crianças com distúrbios abdominais e sua geração é secundária ao aumento da permeabilidade vascular. A contribuição da circulação arterial versus venosa para a formação de edema e acúmulo de líquido peritoneal é mal compreendida. Estudos realizados in vivo mais de duas décadas atrás, sugeriram que a vênulas são mais importantes que os vasos arteriais no processo de formação de edema. O objetivo deste trabalho é analisar os efeitos das mudanças na pressão intravascular e a inflamação mediada pela bradicinina na permeabilidade venosa e vascular mesentérica de ratos. MÉTODO: artérias mesentéricas (MA) e veias (MV) foram montadas em cânulas de vidro, por via intravenosa preenchida com dextran fluorescentes e incremental pressurizado acima de seus valores fisiológicos in vivo. Permeabilidade vascular para dextrana foi determinada a 100, 200 e 300% de pressões fisiológicas. RESULTADOS: a permeabilidade vascular estava presente em todas as medidas para ambos os vasos e sua magnitude diretamente proporcional à pressão intravascular. A bradicinina (10-5 M) aumentou significativamente a permeabilidade da MV, mas não no MA. CONCLUSÃO: o acúmulo de líquido abdominal relacionado à doença inflamatória intestinal é mais provável de ser secundária a venosa, em oposição à fuga vascular arterial.

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Publicado

2010-12-01

Edição

v. 20 n. 3 (2010)

Seção

Pesquisa Original

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