Biological, social, and healthcare factors for death due to influenza A(H1N1) during the 2009 epidemic in Brazil
DOI:
https://doi.org/10.11606/s1518-8787.2024058005855Palabras clave:
Influenza A Virus, H1n1 Subtype, Disease Outbreaks, Risk Factors, Case-Control StudiesResumen
OBJECTIVE: To identify risk factors for death from inf luenza A(H1N1), including the effectiveness of the vaccine against influenza A(H1N1) concerning mortality.
METHODS: A case-control of incident cases of inf luenza A(H1N1) reported in the epidemiological information systems of the states of São Paulo, Paraná, Pará, Amazonas, and Rio Grande do Sul was conducted.
RESULTS: 305 participants were included, 70 of them cases and 235 controls, distributed as follows: Amazonas, 9 cases/10 controls; Pará, 22 cases/77 controls, São Paulo, 19 cases/49 controls; Paraná, 10 cases/54 controls; Rio Grande do Sul, 10 cases/45 controls. These participants had a mean age of 30 years, with 33 years among cases and 25 years among controls. There was a predominance of females both among the cases and controls. Biological (age), pre-existing diseases (congestive heart failure, respiratory disease, and diabetes mellitus), and care factors (ICU admission) associated with death from influenza A(H1N1) were identified.
CONCLUSION: The risk factors identified in this investigation not only allowed subsidizing the elaboration of clinical conducts but also indicate important aspects for facing “new” influenza epidemics that are likely to occur in our country.
Referencias
Centers for Disease Control and Prevention. Novel influenza A (H1N1) virus infections in three pregnant women - United States, April-May 2009. MMWR Morb Mortal Wkly Rep. 2009 May;58(18):497-500.
Charatan F. Mexico City returns to normality, but cases of A/H1N1 reach almost 2000 in US. BMJ. 2009 May;338(may11 2):b1950. https://doi.org/10.1136/bmj.b1950
World Health Organization. Pandemic (H1N1) 2009 - update 76 [cited 2009 Nov 27]. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2009_11_27a-en
Pan American Health Organization. WHO declares H1N1 pandemic over, urges continued influenza vigilance. Washington, DC: Pan American Health Organization; 2010.
Ministério da Saúde (BR), Secretaria de Vigilância em Saúde. Informe epidemiológico, Influenza A H1N1 situação epidemiológica da nova influenza A (H1N1) no Brasil, até semana epidemiológica 44 de 2009. Brasília, DF: Ministério da Saúde; 2009.
Ministério da Saúde (BR). Protocolo de manejo clínico e vigilância epidemiológica da influenza. Brasilia, DF: Ministério da Saúde; 2009.
Wacholder S. Design issues in case-control studies. Stat Methods Med Res. 1995 Dec;4(4):293-309. https://doi.org/10.1177/096228029500400403
Schlesselman JJ, Stolley PD. Case-control studies : design, conduct, analysis. New York: Oxford University Press; 1982.
Yokota RT, Skalinski LM, Igansi CN, de Souza LR, Iser BP, Reis PO, et al. Risk factors for death from pandemic (H1N1) 2009, southern Brazil. Emerg Infect Dis. 2011 Aug;17(8):1467-71. https://doi.org/10.3201/eid1708.101233
Ribeiro AF, Pellini AC, Kitagawa BY, Marques D, Madalosso G, Figueira GCN, et al. Risk factors for death from Influenza A(H1N1)pdm09, State of São Paulo, Brazil, 2009. PLoS One. 2015 Mar;10(3):e0118772. https://doi.org/10.1371/journal.pone.0118772
Sun Y, Wang Q, Yang G, Lin C, Zhang Y, Yang P. Weight and prognosis for influenza A(H1N1) pdm09 infection during the pandemic period between 2009 and 2011: a systematic review of observational studies with meta-analysis. Infect Dis (Lond). 2016;48(11-12):813-22. https://doi.org/10.1080/23744235.2016.1201721
Karlsson EA, Marcelin G, Webby RJ, Schultz-Cherry S. Review on the impact of pregnancy and obesity on influenza virus infection. Influenza Other Respir Viruses. 2012 Nov;6(6):449-60. https://doi.org/10.1111/j.1750-2659.2012.00342.x
Balaganesakumar SR, Murhekar MV, Swamy KK, Kumar MR, Manickam P, Pandian P. Risk factors associated with death among influenza A (H1N1) patients, Tamil Nadu, India, 2010. J Postgrad Med. 2013;59(1):9-14. https://doi.org/10.4103/0022-3859.109481
Martínez A, Soldevila N, Romero-Tamarit A, Torner N, Godoy P, Rius C, et al.; Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group. Risk factors associated with severe outcomes in adult hospitalized patients according to influenza type and subtype. PLoS One. 2019 Jan;14(1):e0210353. https://doi.org/10.1371/journal.pone.0210353
Mata-Marín LA, Mata-Marín JA, Vásquez-Mota VC, Arroyo-Anduiza CI, Gaytán-Martínez JE, Manjarrez-Téllez B, et al. Risk factors associated with mortality in patients infected with influenza A/H1N1 in Mexico. BMC Res Notes. 2015 Sep;8(1):432. https://doi.org/10.1186/s13104-015-1349-8
Santa-Olalla Peralta P, Cortes García M, Limia Sánchez A, Andrés Prado J, Pachón Del Amo I, Sierra Moros MJ. Casos de infección por gripe pandémica (H1N1) 2009 hospitalizados em cuidados intensivos en España: factores asociados a riesgo de muerte, Abril 2009-Enero 2010. Rev Esp Salud Publica. 2010;84(5):547-67. https://doi.org/10.1590/S1135-57272010000500008
Pfitscher LC, Cecatti JG, Pacagnella RC, Haddad SM, Parpinelli MA, Souza JP, et al. Severe maternal morbidity due to respiratory disease and impact of 2009 H1N1 influenza A pandemic in Brazil: results from a national multicenter cross-sectional study. BMC Infect Dis. 2016 May;16(1):220. https://doi.org/10.1186/s12879-016-1525-z
Ribeiro AF, Pellini AC, Kitagawa BY, Marques D, Madalosso G, Fred J, et al. Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009. PLoS One. 2018 Mar;13(3):e0194392. https://doi.org/10.1371/journal.pone.0194392
Jiménez MF, El Beitune P, Salcedo MP, Von Ameln AV, Mastalir FP, Braun LD. Outcomes for pregnant women infected with the influenza A (H1N1) virus during the 2009 pandemic in Porto Alegre, Brazil. Int J Gynaecol Obstet. 2010 Dec;111(3):217-9. https://doi.org/10.1016/j.ijgo.2010.06.024
da Silva AA, Ranieri TM, Torres FD, Vianna FS, Paniz GR, Sanseverino PB, et al. Impact on pregnancies in south Brazil from the influenza A (H1N1) pandemic: cohort study. PLoS One. 2014 Feb;9(2):e88624. https://doi.org/10.1371/journal.pone.0088624
Centro de Estudos Estrategicos da Fiocruz Antonio Ivo de Carvalho. Combate à epidemia de H1N1: um histórico de sucesso. Rio de Janeiro: Fiocruz; 2021.
Mahmud S, Hammond G, Elliott L, Hilderman T, Kurbis C, Caetano P, et al. Effectiveness of the pandemic H1N1 influenza vaccines against laboratory-confirmed H1N1 infections: population-based case-control study. Vaccine. 2011 Oct;29(45):7975-81. https://doi.org/10.1016/j.vaccine.2011.08.068
Lansbury LE, Smith S, Beyer W, Karamehic E, Pasic-Juhas E, Sikira H, et al. Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis. Vaccine. 2017 Apr;35(16):1996-2006. https://doi.org/10.1016/j.vaccine.2017.02.059
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Derechos de autor 2024 Jose Ueleres Braga, Ana Freitas Ribeiro
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Números de la subvención Decit - convenio 728336/2009
