Symmetrical drug-related intertriginous and flexural exanthema induced by Peruvian macado por maca peruana

Authors

  • Lara Braschi Haliski Universidade do Oeste Paulista, Presidente Prudente. Serviço de Dermatologia do Hospital Regional de Presidente Prudente, (SP), Brasil https://orcid.org/0000-0002-6072-775X
  • João Victor Bezerra Universidade do Oeste Paulista, Presidente Prudente. Serviço de Dermatologia do Hospital Regional de Presidente Prudente, (SP), Brasil https://orcid.org/0000-0002-7938-8794
  • Luiza Vasconscelos Universidade do Oeste Paulista, Presidente Prudente. Serviço de Dermatologia do Hospital Regional de Presidente Prudente, (SP), Brasil https://orcid.org/0000-0001-9837-9714
  • Marilda Aparecida Milanez Morgado de Abreu University of the West Paulista. Dermatology Service of the Regional Hospital of Presidente Prudente. Presidente Prudente, (SP), Brazil https://orcid.org/0000-0001-9099-6013

DOI:

https://doi.org/10.11606/issn.2176-7262.rmrp.2024.205103

Keywords:

Drug hypersensitivity, Exanthema, Phytotherapeutic drugs

Abstract

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) or baboon syndrome is an uncommon cutaneous drug eruption that occurs after the systemic administration of drug-related allergens. It is characterized by well-delimited erythema in the gluteal and perianal regions and involvement of other intertriginous /flexural areas, without other systemic signs or symptoms. We present a case of a 73-year-old man who developed erythematous maculopapular exanthema in flexural areas, after using a herbal medication called Peruvian maca (Lepidium meyenii), which has not been previously reported to cause SDRIFE.

Downloads

Author Biographies

  • Lara Braschi Haliski, Universidade do Oeste Paulista, Presidente Prudente. Serviço de Dermatologia do Hospital Regional de Presidente Prudente, (SP), Brasil

    Médica residente de dermatologia

  • João Victor Bezerra , Universidade do Oeste Paulista, Presidente Prudente. Serviço de Dermatologia do Hospital Regional de Presidente Prudente, (SP), Brasil

    Médico residente de dermatologia

  • Luiza Vasconscelos, Universidade do Oeste Paulista, Presidente Prudente. Serviço de Dermatologia do Hospital Regional de Presidente Prudente, (SP), Brasil

    Médica especialista em dermatologia

  • Marilda Aparecida Milanez Morgado de Abreu, University of the West Paulista. Dermatology Service of the Regional Hospital of Presidente Prudente. Presidente Prudente, (SP), Brazil

    Professor (PhD) 

References

Häusermann P, Harr T, Bircher AJ. Baboon syndrome resulting from systemic drugs: is there strife between SDRIFE and allergic contact dermatitis syndrome? Contact Derm. 2004;51:297-310. doi: 10.1111/j.0105-1873.2004.00445.x.

Andersen KE, Hjorth N, Menné T. The baboon syndrome: systemically-induced allergic contact dermatitis. Contact Derm. 1984;10:97-100. doi: 10.1111/j.1600-0536.1984.tb00343.x.

Miyahara A, Kawashima H, Okubo Y, Hoshika A. A new proposal for a clinical oriented subclassification of baboon syndrome and a review of baboon syndrome. Asian Pac J Allergy Immunol. 2011;29(2) 150-60.

Muresan A-M, Metze D, Böer-Auer A, Braun SA. Histopathological spectrum and immunophenotypic characterization of symmetrical drug-related intertriginous and flexural exanthema. Am J Dermatopathol. 2021;43(2):103-11. doi: 10.1097/DAD.0000000000001722.

Tan SC, Tan JW. Symmetrical drug-related intertriginous and flexural exanthema. Curr Opin Allergy Clin Immunol. 2011;11(4):313-318. doi:10.1097/ACI.0b013e3283489d5f

Gonzales GF. Ethnobiology and ethnopharmacology of Lepidium meyenii (Maca), a plant from the peruvian highlands. Evid Based Complement Alternat Med. 2012;2012:193496. doi: 10.1155/2012/193496.

Published

2025-04-10

Issue

Section

Relato de Caso

How to Cite

1.
Haliski LB, Bezerra JV, Vasconscelos L, Abreu MAMM de. Symmetrical drug-related intertriginous and flexural exanthema induced by Peruvian macado por maca peruana. Medicina (Ribeirão Preto) [Internet]. 2025 Apr. 10 [cited 2025 Apr. 20];57(4):e-205103. Available from: https://journals.usp.br/rmrp/article/view/205103