Detecção de SARS-CoV-2 em amostras de sêmen: revisão de escopo
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2022.178463Palavras-chave:
Sêmen, SARS virus, Infecções, DetecçãoResumo
Objetivo: Revisar e resumir as evidências científicas em pesquisas realizadas para detectar a presença de SARS-CoV-2 em amostras de sêmen de pacientes com COVID-19.
Métodos: A pesquisa de literatura foi conduzida nas bases de dados PubMed, Web of Science, Scopus, Medline e Embase. Seguiu o protocolo de revisão de escopo definido por Joanna Briggs Institute (JBI) e baseou-se na pergunta norteadora “É possível detectar SARS-CoV-2 no sêmen de pacientes adultos com diagnóstico confirmado de Covid-19?”.
Resultados: 287 estudos foram identificados, 9 estudos publicados em língua inglesa foram selecionados após análise minuciosa. Três pesquisadores analisaram os estudos em busca de presença de SARS-CoV-2 no fluído seminal, gravidade do paciente, dias desde o início da doença, confirmação diagnóstica, método de coleta de sêmen, método de análise viral e número de amostras.
Conclusões: Não foi possível identificar fortes evidências para confirmar a presença ou ausência de COVID-19 no sêmen de pacientes adultos. Novos estudos sobre o tema devem ser melhor projetados, levando-se em conta as possíveis condições anatômicas e funcionais e mudanças no sistema reprodutor masculino durante e após a infecção por SARS-CoV-2.
Downloads
Referências
World Health Organization [Internet]. Geneva: Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) 16-24 February 2020 [cited 2020 Feb 24]. Available from https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf.
World Health Organization [Internet]. Geneva: Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations: scientific brief, 29 March 2020 [cited 2020 Mar 29]. Available from https://apps.who.int/iris/handle/10665/331616.
Carneiro A, Wroclawski ML, Nahar B, Soares A, Cardoso AP, Kim NJ, et al. Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period. Int Braz J Urol. 2020 Aug;46(4):501-10.
Mazzucchi E, Torricelli FCM, Vicentini FC, Marchini GS, Danilovic A, Batagello CA, et al. The impact of COVID-19 in medical practice. A review focused on Urology. Int Braz J Urol. DOI: 10.1590/S1677-5538.IBJU.2020.99.08.
Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. [Internet]. Treasure Island: Features, Evaluation, and Treatment of Coronavirus (COVID-19) [cited 2020 Nov 10]. Available from https://www.ncbi.nlm.nih.gov/books/NBK554776/.
Xu J, Qi L, Chi X, Yang J, Wei X, Gong E, et al. Orchitis: A Complication of Severe Acute Respiratory Syndrome (SARS). Biol Reprod. 2006 Feb;74(2):410-6.
Yang M, Li H, Sun J, Zhao Y, Tang D. Focus on Characteristics of COVID-19 with the Special Reference to the Impact of COVID-19 on the Urogenital System. Curr Urol. 2020 Jun;14(2):79-84.
Hoffmann M, Kleine-weber H, Schroeder S, Müller MA, Drosten C, Pölmann S. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Apr;181(2):271-80.e8.
Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor Recognition by the Novel Coronavirus form Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol. 2020 Mar;94(7):e00127-20.
Wang Z, Xu X. scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells. 2020 Apr;9(4):920.
Fan C, Li K, Ding Y, Lu WL, Wang J. ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019 2019-nCoV Infection. medRxiv. DOI: 10.1101/2020.02.12.20022418.
Carneiro F, Teixeira TA, Bernardes FS, Pereira MS, Milani G, Duarte-Neto AN et al. Radiological patterns of incidental epididymitis in mild-to-moderate COVID-19 patients revealed by colour Doppler ultrasound. Andrologia. 2021 May;53(4):e13973.
Hallak J, Teixeira TA, Bernardes FS, Carneiro F, Duarte SAS, Pariz JR et al. SARS-CoV-2 and its relationship with the genitourinary tract: Implications for male reproductive health in the context of COVID-19 pandemic. Andrology. 2021 Jan;9(1):73-79
Teixeira TA, Bernardes FS, Oliveira YC, Hsieh MK, Esteves SC, Duarte-Neto AN et al. SARS-CoV-2 and Multi-Organ damage – What men’s health specialists should know about the COVID-19 pathophysiology. Int Braz J Urol. 2021; 47(3):637-646.
Peters MD, Godfrey CM, Khalil H, Mclnerney P, Parker D, Soares CB. Guidance for conducting systematic scoping review. Int J Evid Based Healthc. 2015 Sep;13(3):141-6.
Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018 Oct;169(7):467-73.
Li D, Jin M, Bao P, Zhao W, Zhang S. Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019. JAMA Network Open. 2020 May;3(5):e208292.
Ma L, Xie W, Li D, Shi L, Ye G, Mao Y, et al. Evaluation of sex-related hormones and semen characteristics in reproductive-aged male COVID-19 patients. J Med Virol. DOI: 10.1002/jmv.26259.
Guo L, Zhao S, Li W, Wang Y, Li L, Jiang S, et al. Absence of SARS-CoV-2 in Semen of a COVID-19 Patient Cohort. Andrology. DOI: 10.1111/andr.12848.
Pan F, Xiao X, Guo J, Song Y, Li H, Patel DP, et al: No evidence of severe acute respiratory syndrome–coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertil Steril. 2020 Jun;113(6):1135-9.
Yang M, Chen S, Huang B, Zhong JM, Su H, Chen YJ, et al. Pathological Findings in the Testes of COVID-19 Patients: Clinical Implications. Eur Urol Focus. 2020 Sep;6(5):1124-9.
Paoli D, Pallotti F, Colangelo S, Basilico F, Mazzuti L, Turriziani O, et al. Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab. J Endocrinol Invest. 2020 Dec;43(12):1819-22.
Corona G, Baldi E, Isidori AM, Paoli D, Pallotti F, De Santis L, et al. SARS-CoV-2 infection, male fertility and sperm cryopreservation: a position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) (Società Italiana di Andrologia e Medicina della Sessualità). J Endocrinol Invest. 2020;43(8):1153-7.
Holtmann N, Edimiris P, Andree M, Doehmen C, Baston-Buest D, Adams O, et al. Assessment of SARS-CoV-2 in human semen – a cohort study. Fertil Steril. 2020 Aug;114(2):233-8.
Vishvkarma R, Rajender S. Could SARS-CoV-2 affect male fertility? Andrologia. 2020 Oct;52(9):e13712.
Tsokos M. Pathology of Sepsis. In: Rutty GN, editor. Essentials of Autopsy Practice. London: Springer; 2006. P. 39-85.
Madabhavi I, Sarkar M, Kadakol N. COVID-19: a review. Monaldi Arch for Chest Dis. 2020 May;90(2):248-58.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar;395(10229):1054-62.
To KKW, Tsang OTY, Leung WS, Tam AR, Wu TC, Lung DC, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis. 2020 May;20(5):565-74.
Downloads
Publicado
Edição
Seção
Licença
Copyright (c) 2022 Luís Expedito Sabage, Guilherme Akira Otani, Leandro Tonderys Guidio, Alessandra Mazzo, Victor Augusto Scheirer Leitão, Carlos Ferreira dos Santos, Aguinaldo César Nardi
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
