Sources of hematopoietic stem cells for transplantation

Authors

  • Wellington Azevedo Serviço de Transplante de Medula Óssea do Hospital das Clínicas da Universidade Federal de Minas Gerais
  • Maria Cecília C. Ribeiro

DOI:

https://doi.org/10.11606/issn.2176-7262.v33i4p381-389

Keywords:

Bone Marrow Transplantation. Hematopoietic Stem Cell. Hematopoietic Cell Growth Factors.

Abstract

Currently, several types of hematopoietic stem cells (HSC), from different tissues and donors, are available for transplantation to human beings. In this review, we discuss the use of allogeneic HSC harvested directly from the bone marrow or mobilized to the peripheral blood with hematopoietic growth factors. We compared these two types of transplants regarding to engraftment, relapse, acute and chronic graft-versus-host disease and survival. Although there is a clear advantage of PBSCT over BMT in the early posttransplant period, higher frequency of cGVHD in PBSCT and relatively short followup of patients do not recommend generalized adoption of allogeneic HSCT so far.

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Author Biographies

  • Wellington Azevedo, Serviço de Transplante de Medula Óssea do Hospital das Clínicas da Universidade Federal de Minas Gerais

    Diretor do Serviço de Transplante de Medula Óssea do Hospital das Clínicas da Universidade Federal de Minas Gerais.

  • Maria Cecília C. Ribeiro

    Médica Hematologista.

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Published

2000-12-30

Issue

Vol. 33 No. 4 (2000)

Section

Simpósio: Transplante de Medula Óssea: 2º Parte

License

 

 

How to Cite

1.
Azevedo W, Ribeiro MCC. Sources of hematopoietic stem cells for transplantation. Medicina (Ribeirão Preto) [Internet]. 2000 Dec. 30 [cited 2024 Jun. 29];33(4):381-9. Available from: https://journals.usp.br/rmrp/article/view/7714