Frequency of histocompatibity antigens in the normal population of the northeast region of the state of São Paulo Brazil

Abstract

Type of study : prevalence study. Objectives: to evaluate the frequency of class I and class II histocompatibity antigens in the normal population of the Northeast region of the State of São Paulo, Brazil. Methods: three groups of healthy individuals were studied: the staff personnel of the University Hospital and School of Medicine of Ribeirão Preto; local blood donors, and the cadaveric donors for solid organ transplantation. HLA antigens were typed by a complement-dependent microlymphocytotoxicity assay. Results: HLA frequencies among individulas from the 3 groups sutudied here were similar. Conclusions: HLA frequency observed in any of these populations may be used for donor selection purposes and for HLA and disease association studies.