Mohs micrographic surgery in the treatment of non-melanocytic skin neoplasms

Authors

DOI:

https://doi.org/10.11606/issn.2176-7262.rmrp.2021.170517

Keywords:

Mohs surgery, Skin neoplasms, Systematic review

Abstract

Objective: Evaluating the effectiveness of using MOHS surgery in the management of non-melanoma skin tumors compared to other therapy methods. Methods: The study consists of a systematic review, whose search for articles was performed using databases MEDLINE, PubMed Central (PMC), LILACS and SciELO, using the terms “MOHS surgery”, “Skin cancer”, “Clinical trial”, excluding “melanoma”. Results: from a total of 132 identified articles, 11 were considered eligible. The analysis of the articles showed that MMS, compared to other methods, presented better cosmetic results, in addition to a lower grade of complications in recurrent tumors and a variable cost/benefit according to the country where the surgery was performed. MMS also had lower recurrence rates in all studies. Conclusion: Overall, MOHS surgery has shown promising therapeutic results. However, there are still few comparative studies on the effectiveness of MMS and those that exist are concentrated in a few regions of the world.

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Author Biographies

  • João Augusto Gomes de Souza Monteiro de Brito, Universidade do Estado do Pará, Belém (PA), Brasil.

    Médico. Professor,  mestre do curso de Medicina

  • Lucas da Silva Lopes, Universidade do Estado do Pará, Belém (PA), Brasil.

    Graduando do curso de Medicina

  • Ana Luísa Gross Rodrigues, Universidade do Estado do Pará, Belém (PA), Brasil

    Graduanda do curso de Medicina

  • Caio Vinicius Botelho Brito, Universidade do Estado do Pará, Belém (PA), Brasil

    Graduando do curso de Medicina

References

Ladda MA, Lynde CW. Mohs Micrographic Surgery: Development of the Technique. J cutan medic surger. 2019; 23(2): 236.

Wong E, Axibal E, Brown M. Mohs Micrographic Surgery. Facial Plast Surg Clin North Am. 2019; 27(1): 15-34.

Van loo E, Mosterd K, Krekels GA, Roozeboom MH, Ostertag JU, Dirksen CD, et al. Surgical excision versus Mohs' micrographic surgery for basal cell carcinoma of the face: a randomised clinical trial with 10 year followup. Eur J Cancer. 2014; 50(17): 3011–20.

Kauvar AN, Cronin JRT, Roenigk R, Hruza G, Bennett R. Consensus for nonmelanoma skin cancer treatment: basal cell carcinoma, including a cost analysis of treatment methods. Dermatol Surg. 2015; 41(5): 550-71.

Tanese K. Diagnosis and Management of Basal Cell Carcinoma. Curr Opin Oncol. 2019; 20(2): 1-13.

Murray C, Silva JD, Hanna TP, Bradshaw S, Solish N, Moran B, et al. Patient indications for Mohs micrographic surgery: a clinical practice guideline. Curr Opin Oncol. 2019; 26(1): 94-99.

Sanchez FH, Estefan JL, Estefan LL. Cirurgia micrográfica de Mohs: estudo de 93 tumores operados em um centro de referência no Rio de Janeiro. Surg Cosm Derm. 2013; 5(3): 206-10.

Pontes LT. Cirurgia micrográfica de Mohs em um serviço universitário: estudo retrospetivo de 5 anos [dissertação]. Campinas: Universidade Estadual de Campinas, Faculdade de Ciências Médicas; 2016.

Reeder VJ, Gustafson C J, Mireku K, Davis SA, Feldman SR, Pearce DJ. Trends in Mohs surgery from 1995 to 2010: an analysis of nationally representative data. Derm Surg. 2015; 41(3): 397-403

Correia STR, Silva R, Lopes JM. Carcinoma basocelular da pele (parte 2): diagnóstico, prognóstico e manejo. Future Oncology. 2015; 11(22): 3023-38.

Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Itens de relatório preferidos para revisões sistemáticas e metanálises: a declaração PRISMA. PLoS Med. 2009; 6(7): e1000097.

Patel R, Strimling R, Doggett S, Willoughby M, Miller K, Dardick L, et al. Comparison of electronic brachytherapy and Mohs micrographic surgery for the treatment of early-stage non-melanoma skin cancer: a matched pair cohort study. J Contemp Brachytherapy. 2017; 9(4): 338–44.

Essers BAB, Dirksen CD, Nieman FHM, Smeets NWJ, Krekels GAM, Prins MH, et al. Cost-effectiveness of Mohs Micrographic Surgery vs Surgical Excision for Basal Cell Carcinoma of the Face. Arch Dermatol. 2006; 142(2): 187-94.

Smeets NWJ, Krekels GAM, Ostertag JU, Essers BAB, Dirksen CD, Nieman FHM, et al. Surgical excision vs Mohs’ micrographic surgery for basal-cell carcinoma of the face: randomised controlled trial. Lancet. 2004; 364(9447): 1766–72.

Davis JL, Randle HW, Zalla MJ, Roenigk RK, Brodland DG. A comparison of Mohs Micrografic Surgery and wide excision for the treatment of atypical fibroxantoma. Dermatol Surg. 1997; 23(2): 105-10.

Tolkachjov SN, Kelley BF, Alahdab F, Erwin PJ, Brewer JD. Atypical fibroxanthoma: Systematic review and meta-analysis of treatment with Mohs micrographic surgery or excision. J Am Acad Dermatol. 2008; 79(5): 929-34.

Dubay D, Cimmino V, Lowe L, Johnson TM, Sondak VK. Low Recurrence Rate after Surgery for Dermatofibrosarcoma Protuberans: a multidisciplinary approach from a single institution. Cancer. 2004; 100(5): 1008–16.

Boyer JD, Ziteli JA, Brodland DG, D`Angelo G. Local control of primary Merkel cell carcinoma: Review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation. J Am Acad Dermatol. 2002; 47(6): 885-92.

Wain RAJ, Tehrani H. Reconstructive outcomes of Mohs surgery compared with conventional excision: A 13-month prospective study. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2015; 68(7): 946-52

Chren MM, Sahay AP, Bertenthal DS, Sen S, Landerfeld CS. Quality of Life Outcomes of Treatments for Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma. Journal of Investig Dermatol. 2007; 127(6): 1351–57.

Muller FM, Dawe RS, Moseley H, Fleming CJ. Randomized Comparison of Mohs Micrographic Surgery and Surgical Excision for Small Nodular Basal Cell Carcinoma: Tissue-Sparing Outcome. Dermatol Surg. 2009; 35(9): 1349-54.

Ravitskiy L, Brodland DG, Zitelli JA. Cost Analysis: Mohs Micrographic Surgery. Dermatol Surg. 2012; 38(4): 585–94.

Cook J, Ziteli JA. Mohs micrographic surgery: A cost analysis. J Am Acad Dermatol. 1998; 39(5): 698-703

Published

2021-12-20

Issue

Section

Review

How to Cite

1.
Brito JAG de SM de, Lopes L da S, Rodrigues ALG, Brito CVB. Mohs micrographic surgery in the treatment of non-melanocytic skin neoplasms. Medicina (Ribeirão Preto) [Internet]. 2021 Dec. 20 [cited 2024 Dec. 18];54(3):e-170517. Available from: https://journals.usp.br/rmrp/article/view/170517