Epinephrine in cardiac arrest: systematic review and meta-analysis

Authors

  • Ignacio Morales-Cané Instituto Maimónides de Investigación Biomédica de Córdoba
  • María Del Rocío Valverde-León Universidad de Córdoba
  • María Aurora Rodríguez-Borrego Instituto Maimónides de Investigación Biomédica de Córdoba

DOI:

https://doi.org/10.1590/1518-8345.1317.2821

Abstract

Objective: evaluate the effectiveness of epinephrine used during cardiac arrest and its effect on the survival rates and neurological condition. Method: systematic review of scientific literature with meta-analysis, using a random effects model. The following databases were used to research clinical trials and observational studies: Medline, Embase and Cochrane, from 2005 to 2015. Results: when the Return of Spontaneous Circulation (ROSC) with administration of epinephrine was compared with ROSC without administration, increased rates were found with administration (OR 2.02. 95% CI 1.49 to 2.75; I2 = 95%). Meta-analysis showed an increase in survival to discharge or 30 days after administration of epinephrine (OR 1.23; 95% IC 1.05-1.44; I2=83%). Stratification by shockable and non-shockable rhythms showed an increase in survival for non-shockable rhythm (OR 1.52; 95% IC 1.29-1.78; I2=42%). When compared with delayed administration, the administration of epinephrine within 10 minutes showed an increased survival rate (OR 2.03; 95% IC 1.77-2.32; I2=0%). Conclusion: administration of epinephrine appears to increase the rate of ROSC, but when compared with other therapies, no positive effect was found on survival rates of patients with favorable neurological status.

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Published

2016-01-01

Issue

Vol. 24 (2016)

Section

Original Articles

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How to Cite

Epinephrine in cardiac arrest: systematic review and meta-analysis . (2016). Revista Latino-Americana De Enfermagem, 24, e2821-. https://doi.org/10.1590/1518-8345.1317.2821