Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era
Palabras clave:
Vulvovaginal candidiasis., Candida albicans, HIV, Virulence, Genetic variabilityResumen
Vulvovaginal candidiasis (VVC) in HIV-infected (HIV+) women is a serious public health problem. However, little is known about the virulence mechanisms of vaginal Candida albicans from HIV+ women in the post-highly active antiretroviral therapy (HAART) era. Here, we report a comparative analysis of the expression of key virulence factors and genetic variability of 26 vaginal C. albicans strains isolated from HIV+ women undergoing HAART and 18 from HIV-uninfected (HIV-) women. In general, we observed that C. albicans from HIV+ women receiving HAART showed lower expression of virulence factors compared with C. albicans from HIV- women, except for the proteinase activity which is highly expressed. The results in HIV-women further suggest that virulence factors appear to be expressed in response to the yeast stress, in the presence of an adequate immune response. Furthermore, the RAPD results showed a high heterogeneity among isolates from both groups of women. These findings in HIV+ women using HAART will help to improve the monitoring of vaginal yeast infections and the quality of life of patients.Descargas
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2017-01-01
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Zanni, P. C. M. D., Bonfim-Mendonça, P. de S., Negri, M., Nakamura, S. S., Donatti, L., Svidzinski, T. I. E., & Consolaro, M. E. L. (2017). Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era. Revista Do Instituto De Medicina Tropical De São Paulo, 59, e44. https://journals.usp.br/rimtsp/article/view/140665