Noto on the in vitro inhibitory effect of phenothiazine upon the embryonic development of Ascaridia Galli) (Schrank, 1788)

Abstract

Studying the “in vitro” effect of phenothiazine upon the embryonic development of A. galli — at various phases of their evolution — the author was able to conclude:
a) The eggs were highly susceptible to an inhibitory action of the drug, provided the treatment started inside the first three days of development, at 28° C; after the third day the susceptibility decreased rapidly, seeming to disappear after the seventh day of evolution at the above temperature;
b) When the treatment was instituted on the first day, a 24 hour period of contact of the eggs with the drug was enough to determine an irreversible inhibition of embryonic development in all of them .