Nuclear transcription factor Kappa B in the central nervous system: from physiological to pathological
DOI:
https://doi.org/10.11606/issn.1984-5154.v4p35-39Keywords:
canonical and non-canonical pathways, cell survival, neurodegenerative diseasesAbstract
First discovered in T cells, the nuclear transcription factor kappa B (NF-kB) has been described in all mammalian cells, regulating the expression of several genes, mainly those related to immune response. In the central nervous system gene expression regulated by NF-kB is of particular importance since it may be involved in both physiological conditions (synapse, development and neural plasticity) and pathological conditions that result in cell death. In this review we describe the two main forms of NF-kB activation and the participation of this factor in different processes of central nervous system
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Alcamo, E., Hacohen, N., Schulte, L.C., Rennert, P.D., Hynes, R.O. e Baltimore, D. (2002). Requirement for the NF- κB family member RelA in the development of secondary lymphoid organs. Journal of Experimental Medicine 195, 233–244.
Bhakar, A.L., Tannis, L.L., Zeindler, C., Russo, M.P., Jobin, C., Park, D.S., MacPherson, S. e Barker P.A (2002). Constitutive nuclear factor-kappa B activity is required for central neuron survival. The Journal of Neuroscience 22, 8466–8475.
Barger, S.W. e Mattson, M.P. (1996). Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer’s β-amyloid precursor. Brain Research. Molecular Brain Research 40, 116–126.
Fernyhough, P., Smith, D.R., Schapansky, J., Ploeg, R.V.D., Gardiner, N.J., Tweed, C.W., Kontos, A., Freeman, L., Purves-Tyson, T.D. e Glazner, G.W. (2005). Activation f Nuclear Factor-B via Endogenous Tumor Necrosis Factor α regulates survival of axotomized adult sensory neurons. The Journal of Neuroscience 25, 1682–1690.
Fridmacher, V., Kaltschmidt, B., Goudeau, B., Ndiaye, D., Rossi, F.M., Pfeiffer, J., Kaltschmidt, C., Israël, A. e Mémet, S. (2003). Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection. The Journal of Neuroscience. 23, 9403–9408.
Guerrini, L., Blasi, F. e Denis-Donini, S. (1995). Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro. Proceeding of the National Academy of Science of United States of America 92, 9077–9081.
Grilli, M. e Memo, M. (1999). Nuclear Factor-kB/Rel Proteins: A point of convergence of signalling pathway relevant in neuronal function and dysfunction. Biochemical Pharmacology 57, 1–7.
Kaltschmidt, B., Widera, D. e Kaltschmidt, C. (2005). Signaling via NF-κB in the nervous system. Biochemica et Biophysica Acta 1745, 287–299.
Malek, R., Borowicz, K.K., Jargielo, M. e Czuczwar, S.J. (2007). Role of nuclear factor kB in the central nervous system. Pharmacological Reports 59, 25-33.
Mattson, M.P. e Camandola, S. (2001). NF-κB in neuronal plasticity and neurodegenerative disorders. The Journal of Clinical Investigation 107, 247–254.
Meberg, P.J., Kinney, W.R., Valcourt, E.G. e Routtenberg, A. (1996). Gene expression of the transcription factor NF-kappa B in hippocampus: regulation by synaptic activity. Brain Research. Molecular Brain Research 38,179-190.
Meffert, M.K. e Baltimore, D. (2005). Physiological functions for brain NF-κB. TRENDS in Neurosciences 28: 27–43.
Meffert, M.K., Chang, J.M., Wiltgen, B.J., Fanselow, M.S. e Baltimore, D. (2003). NF-kB functions in synaptic signaling and behavior. Natural Neuroscience 6, 1072- 1078.
Mercurio, F., Murray, B.W., Shevchenko, A., Bennett, B.L., Young, D.B., Li, J.W., Pascual, G., Motiwala, A., Zhu, H., Mann, M. e Manning, A.M. (1999). IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Molecular Cell
Biology 19, 1526–1538.
Nabel, G. e Baltimore, D. (1987). An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326, 711– 713.
O’Neill, L.A. e Kaltschmidt, C. (1997). NF-kappa B: a crucial transcription factor for glial and neuronal cell function. Trends of Neuroscience 20, 252–258.
Pizzi, M. e Spano, P. (2006). Distinct roles of diverse nuclear factor-κB complexes in neuropathological mechanisms. European Journal of Pharmacology 545, 22–28.
Ramakrishnan, P., Wang, W. e Wallach, D. (2004). Receptor-specific signaling for both the alternative and the canonical NF-κB activation pathway by NF-κB-nducing kinase. Immunity 21, 477–489.
Ridder, D.A. e Schwaninger, M. (2009). NF-κB signiling in cerebral inchemia. Neuroscience 158, 995–1006.
Scheidereit, C. (2006). IkappaB kinase complexes: gateways o NF-kappaB activation and transcription. Oncogenese 25, 6685–66705.
Schmidt-Ullrich, R., Mémet, S., Lilienbaum, A., Feuillard, J., Raphaël, M. e Israel, A. (1996). NF-kappaB activity in transgenic mice: developmental regulation and tissue specificity. Development 122, 2117-2128.
Solt, L.A. e May, M.J. (2008). The IkB kinase complex: master regulator of NF-kB signaling. Immunology Research 42, 3–8.
Terai, K., Matsuo, A. e McGeer, P.L. (1996). Enhancement of immunoreactivity for NF-kB in the hippocampal formation and cerebral cortex of Alzheimer’s disease. Brain Research 735, 159–168.
Xiao, W. (2004). Advances in NF-κB signaling transduction and transcription. Cellular & Molecular Immunology 1, 425–433.
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