Investigation of the antimycobacterial activity of 36 plant extracts from the brazilian Atlantic Forest

Authors

  • Daniela Fernandes Ramos Universidade Federal do Rio Grande do Sul; Departamento de Patologia; Laboratório de Micobactérias
  • Gilda Guimarães Leitão Universidade Federal do Rio de Janeiro; Núcleo de Pesquisas de Produtos Naturais
  • Fernanda das Neves Costa Universidade Federal do Rio de Janeiro; Núcleo de Pesquisas de Produtos Naturais
  • Lisandra Abreu Universidade Federal do Rio de Janeiro; Núcleo de Pesquisas de Produtos Naturais
  • Javier Vargas Villarreal Centro de Investigación Biomédica del Noreste; Instituto Mexicano Del Seguro Social
  • Suzana Guimarães Leitão Universidade Federal do Rio de Janeiro; Núcleo de Pesquisas de Produtos Naturais
  • Salvador Luis Said y Fernández Centro de Investigación Biomédica del Noreste; Instituto Mexicano Del Seguro Social
  • Pedro Eduardo Almeida da Silva Universidade Federal do Rio Grande do Sul; Departamento de Patologia; Laboratório de Micobactérias

DOI:

https://doi.org/10.1590/S1516-93322008000400013

Keywords:

Mycobacterium tuberculosis, Mycobacterium kansasii, Plant extracts^i1^santimycobacterial activ, Antimycobacterials, Cytotoxicity

Abstract

Thirty-six plant extracts from the brazilian Atlantic Forest were tested for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv and M. kansasii, using the method REMA in seriate concentrations of 100 to 0.20 µg/mL. Among the thirty six extracts tested, five were active against M. tuberculosis, and three of these extracts also showed activity against M. kansasii. Cytotoxicity test with VERO cells was performed with the five extracts active against M. tuberculosis. Only the extract of Peschiera affinis was identified as non-toxic in the concentration of 100µg/mL.

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Published

2008-12-01

Issue

Vol. 44 No. 4 (2008)

Section

Original Papers

How to Cite

Investigation of the antimycobacterial activity of 36 plant extracts from the brazilian Atlantic Forest. (2008). Revista Brasileira De Ciências Farmacêuticas, 44(4), 669-674. https://doi.org/10.1590/S1516-93322008000400013