Evaluation of the response to the Awake Prone Position in Patients with COVID-19
DOI:
https://doi.org/10.1590/1809-2950/21018529012022PTKeywords:
COVID-19, Coronavirus, Prone positioning, ; Intubation, Therapy; Intensive Care UnitsAbstract
To evaluate the acute effects of types of response to the prone position (PP) in patients awake with COVID-19. Prospective, single-center study with 32 patients awake with COVID-19, with supplemental oxygen. The response to the prone position was performed for 30 minutes. After the test, they were instructed to remain on the PP daily, according to tolerance. The variables SpO2, heart rate, respiratory rate, ROX index, and ICU admission rate were recorded. A total of 25 patients (78.1%) responded to PP, with 13 (40.6%) showing persistent response and 12 (37.5%) transient. 7 patients (21.9%) did not respond. Patients with persistent and transient responses increased SpO2 (p <0.001), ROX index (p = 0.001 and p <0.001, respectively) and reduced heart rate (p = 0.01 and p = 0.02, respectively) and respiratory (p = 0.003 and p = 0.001, respectively), compared to the pre. There was no difference in all variables in patients who did not respond to PP. The rate of hospitalization in the ICU of patients who presented a persistent, transient response or who did not respond was 30.8% (4/13), 41.7% (5/12) and 57.1% (4/7), respectively. We can conclude that the patients who responded to PP showed a reduction in heart and respiratory rates, an increase in the ROX index. There was no difference in the hospitalization rate.
Downloads
References
Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA [Internet]. 2020 May 26;323(20):2052–9. Available from: http://dx.doi.org/10.1001/jama.2020.6775
Sztajnbok J, Maselli-Schoueri JH, Cunha de Resende Brasil LM, Farias de Sousa L, Cordeiro CM, Sansão Borges LM, et al. Prone positioning to improve oxygenation and relieve respiratory symptoms in awake, spontaneously breathing non-intubated patients with COVID-19 pneumonia. Respir Med Case Rep [Internet]. 2020 May 19;30:101096. Available from: http://dx.doi.org/10.1016/j.rmcr.2020.101096
Albert RK, Hubmayr RD. The prone position eliminates compression of the lungs by the heart. Am J Respir Crit Care Med [Internet]. 2000 May;161(5):1660–5. Available from: http://dx.doi.org/10.1164/ajrccm.161.5.9901037
Guérin C, Reignier J, Richard J-C, Beuret P, Gacouin A, Boulain T, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med [Internet]. 2013 Jun 6;368(23):2159–68. Available from: http://dx.doi.org/10.1056/NEJMoa1214103
Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, et al. Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). Crit Care Med [Internet]. 2020 Jun;48(6):e440–69. Available from: http://dx.doi.org/10.1097/CCM.0000000000004363
Jiang LG, LeBaron J, Bodnar D, Caputo ND, Chang BP, Chiricolo G, et al. Conscious Proning: An Introduction of a Proning Protocol for Nonintubated, Awake, Hypoxic Emergency Department COVID-19 Patients. Acad Emerg Med [Internet]. 2020 Jul;27(7):566–9. Available from: http://dx.doi.org/10.1111/acem.14035
Ding L, Wang L, Ma W, He H. Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study. Crit Care [Internet]. 2020 Jan 30;24(1):28. Available from: http://dx.doi.org/10.1186/s13054-020-2738-5
Coppo A, Bellani G, Winterton D, Di Pierro M, Soria A, Faverio P, et al. Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): a prospective cohort study. Lancet Respir Med [Internet]. 2020 Aug;8(8):765–74. Available from: http://dx.doi.org/10.1016/S2213-2600(20)30268-X
Ng Z, Tay WC, Ho CHB. Awake prone positioning for non-intubated oxygen dependent COVID-19 pneumonia patients. Eur Respir J [Internet]. 2020 Jul;56(1). Available from: http://dx.doi.org/10.1183/13993003.01198-2020
Hopkins SR, Henderson AC, Levin DL, Yamada K, Arai T, Buxton RB, et al. Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect. J Appl Physiol [Internet]. 2007 Jul;103(1):240–8. Available from: http://dx.doi.org/10.1152/japplphysiol.01289.2006
Ferrando C, Mellado-Artigas R, Gea A, Arruti E, Aldecoa C, Adalia R, et al. Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study. Crit Care [Internet]. 2020 Oct 6;24(1):597. Available from: http://dx.doi.org/10.1186/s13054-020-03314-6
Hopkins SR, Henderson AC, Levin DL, Yamada K, Arai T, Buxton RB, et al. Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect. J Appl Physiol [Internet]. 2007 Jul;103(1):240–8. Available from: http://dx.doi.org/10.1152/japplphysiol.01289.2006
Anand S, Baishya M, Singh A, Khanna P. Effect of awake prone positioning in COVID-19 patients- A systematic review. Tren Anaesth Crit Care [Internet]. 2021 Feb;36:17–22. Available from: https://doi.org/10.1016/j.tacc.2020.09.008
Taboada M, Rodríguez N, Riveiro V, Baluja A, Atanassoff PG. Prone positioning in awake non-ICU patients with ARDS caused by COVID-19. Anaesth Crit Care Pain Med [Internet]. 2020 Oct;39(5):581–3. Available from: http://dx.doi.org/10.1016/j.accpm.2020.08.002
Thompson AE, Ranard BL, Wei Y, Jelic S. Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure. JAMA Intern Med [Internet]. 2020 Jun 17; Available from: http://dx.doi.org/10.1001/jamainternmed.2020.3030
Elharrar X, Trigui Y, Dols A-M, Touchon F, Martinez S, Prud’homme E, et al. Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure. JAMA [Internet]. 2020 Jun 9;323(22):2336–8. Available from: http://dx.doi.org/10.1001/jama.2020.8255
Cardona S, Downing J, Alfalasi R, Bzhilyanskaya V, Milzman D, Rehan M, et al. Intubation rate of patients with hypoxia due to COVID-19 treated with awake proning: A meta-analysis. Am J Emerg Med [Internet]. 2021 May;43:88–96. Available from: http://dx.doi.org/10.1016/j.ajem.2021.01.058
Telias I, Katira BH, Brochard L. Is the Prone Position Helpful During Spontaneous Breathing in Patients With COVID-19? JAMA [Internet]. 2020 Jun 9;323(22):2265–7. Available from: http://dx.doi.org/10.1001/jama.2020.8539
Weatherald J, Solverson K, Zuege DJ, Loroff N, Fiest KM, Parhar KKS. Awake prone positioning for COVID-19 hypoxemic respiratory failure: A rapid review. J Crit Care [Internet]. 2021 Feb;61:63–70. Available from: http://dx.doi.org/10.1016/j.jcrc.2020.08.018
Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, et al. An Index Combining Respiratory Rate and Oxygenation to Predict Outcome of Nasal High-Flow Therapy [Internet]. Vol. 199, American Journal of Respiratory and Critical Care Medicine. 2019. p. 1368–76. Available from: http://dx.doi.org/10.1164/rccm.201803-0589oc
Zaboli A, Ausserhofer D, Pfeifer N, Sibilio S, Tezza G, Ciccariello L, et al. The ROX index can be a useful tool for the triage evaluation of COVID-19 patients with dyspnoea. J Adv Nurs [Internet]. 2021 Apr 1; Available from: http://dx.doi.org/10.1111/jan.14848
Winearls S, Swingwood EL, Hardaker CL, Smith AM, Easton FM, Millington KJ, et al. Early conscious prone positioning in patients with COVID-19 receiving continuous positive airway pressure: a retrospective analysis. BMJ Open Respir Res [Internet]. 2020 Sep;7(1). Available from: http://dx.doi.org/10.1136/bmjresp-2020-000711
Panadero C, Abad-Fernández A, Rio-Ramirez MT, Acosta Gutierrez CM, Calderon-Alcala M, Lopez-Riolobos C, et al. High-flow nasal cannula for Acute Respiratory Distress Syndrome (ARDS) due to COVID-19. Multidiscip Respir Med [Internet]. 2020 Jan 28;15(1):693. Available from: http://dx.doi.org/10.4081/mrm.2020.693
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Angélica Bologna Raposo, Alice Haniuda Moliterno, João Pedro Lucas Neves Silva, Rafael Varago Fabri, Ana Paula Coelho Figueira Freire, Francia Lopes Pacagnelli
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.