Epidemiology and biology of cutaneous human papillomavirus

Authors

  • Emily M. Nunes Universidade de Sao Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto do Cancer do Estado de Sao Paulo
  • Valéria Talpe-Nunes Universidade de Sao Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto do Cancer do Estado de Sao Paulo
  • Laura Sichero Universidade de Sao Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto do Cancer do Estado de Sao Paulo

DOI:

https://doi.org/10.6061/clinics/2018/e489s

Keywords:

Human Papillomavirus, Cutaneous, Prevalence, Nonmelanoma Skin Cancer

Abstract

Cutaneous human papillomaviruses (HPVs) include b- and g-HPVs, in addition to a small fraction of a-HPVs. b-HPVs were first isolated from patients with the rare genetic disorder Epidermodysplasia verruciformis, and they are associated with the development of nonmelanoma skin cancer at sun-exposed skin sites in these individuals. Organ transplant recipients also have greater susceptibility to b-HPV infection of the skin and an increased risk of developing nonmelanoma skin cancer. In both immunosuppressed and immunocompromised individuals, cutaneous HPVs are ubiquitously disseminated throughout healthy skin and may be an intrinsic part of the commensal flora. Functional analysis of E6 and E7 proteins of specific cutaneous HPVs has provided a mechanistic comprehension of how these viruses may induce carcinogenesis. Nevertheless, additional research is crucial to better understand the pathological implications of the broad distribution of these HPVs.

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Published

2019-02-14

Issue

Section

Review Articles

How to Cite

Nunes, E. M., Talpe-Nunes, V., & Sichero, L. (2019). Epidemiology and biology of cutaneous human papillomavirus. Clinics, 73(Suppl. 1), e489s. https://doi.org/10.6061/clinics/2018/e489s