Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers

Authors

  • Fernando Marcuz Silva Universidade de São Paulo; Faculdade de Medicina; Division of Clinical Medicine and Propaedeutics; Hospital das Clínicas
  • Elaine Cristina Silveira de Queiroz Universidade de São Paulo; Faculdade de Medicina; Division of Clinical Medicine and Propaedeutics; Hospital das Clínicas
  • Tomás Navarro-Rodriguez Universidade de São Paulo; Faculdade de Medicina; Division of Gastroenterology and Clinical Hepatology; Hospital das Clínicas
  • Ricardo Correa Barbuti Universidade de São Paulo; Faculdade de Medicina; Division of Gastroenterology and Clinical Hepatology; Hospital das Clínicas
  • Rejane Mattar Universidade de São Paulo; Faculdade de Medicina; Division of Gastroenterology and Clinical Hepatology; Hospital das Clínicas
  • Kiyoshi Iriya Universidade de São Paulo; Faculdade de Medicina; Division of Anatomic Pathology; Hospital das Clínicas
  • Jin Hwa Lee Universidade de São Paulo; Faculdade de Medicina; Division of Anatomic Pathology; Hospital das Clínicas
  • Jaime Natan Eisig Universidade de São Paulo; Faculdade de Medicina; Division of Gastroenterology and Clinical Hepatology; Hospital das Clínicas

DOI:

https://doi.org/10.6061/clinics/2015(05)02

Abstract

OBJECTIVES: The eradication of Helicobacter (H.) pylori allows peptic ulcers in patients infected with the bacteria to be cured. Treatment with the classic triple regimen (proton pump inhibitor, amoxicillin and clarithromycin) has shown decreased efficacy due to increased bacterial resistance to clarithromycin. In our country, the eradication rate by intention to treat with this regimen is 83%. In Brazil, a commercially available regimen for bacterial eradication that uses levofloxacin and amoxicillin with lansoprazole is available; however, its efficacy is not known. Considering that such a treatment may be an alternative to the classic regimen, we aimed to verify its efficacy in H. pylori eradication. METHODS: Patients with peptic ulcer disease infected with H. pylori who had not received prior treatment were treated with the following regimen: 30 mg lansoprazole bid, 1,000 mg amoxicillin bid and 500 mg levofloxacin, once a day for 7 days. RESULTS: A total of 66 patients were evaluated. The patients’ mean age was 52 years, and women comprised 55% of the sample. Duodenal ulcers were present in 50% of cases, and gastric ulcers were present in 30%. The eradication rate was 74% per protocol and 73% by intention to treat. Adverse effects were reported by 49 patients (74%) and were mild to moderate, with a prevalence of diarrhea complaints. CONCLUSIONS: Triple therapy comprising lansoprazole, amoxicillin and levofloxacin for 7 days for the eradication of H. pylori in Brazilian peptic ulcer patients showed a lower efficacy than that of the classic triple regimen.

Downloads

Download data is not yet available.

Downloads

Published

2015-05-01

Issue

Section

Clinical Sciences

How to Cite

Silva, F. M., Queiroz, E. C. S. de, Navarro-Rodriguez, T., Barbuti, R. C., Mattar, R., Iriya, K., Lee, J. H., & Eisig, J. N. (2015). Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers. Clinics, 70(5), 318-321. https://doi.org/10.6061/clinics/2015(05)02