Rare primary choroidal melanoma in a dog, with optic nerve infiltration
DOI:
https://doi.org/10.11606/issn.1678-4456.bjvras.2022.191917Keywords:
Choroidal melanoma, Dog eye, Ocular neoplasm, Optic nerve infiltrationAbstract
Intraocular melanocytic neoplasms are common in dogs. However, the choroidal location of these neoplasms and their infiltration into the optic nerve are unusual. This paper reports a case of primary choroidal melanoma in a 12-year-old male Dachshund. On the first examination, the animal presented left eye blepharospasm, protrusion of the nictitating membrane, conjunctival hyperemia, moderate congestion, hyphema, and intraocular hypertension. Opacity hindered the performance of fundoscopy in the affected eye. The ocular ultrasound examination revealed a cupuliform mass in the choroid. Due to suspected intraocular neoplasia, an exenteration was performed. Histopathological examination revealed primary choroidal melanoma with scleral and optic nerve invasion.
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Badanes Z, Espinheira Gomes F, Ledbetter EC. Choroidal melanocytic tumors in dogs: a retrospective study. Vet Ophthalmol. 2020;23(6):987-93. https://doi.org/10.1111/vop.12839. PMid:33085213.
Dubielzig RR, Aguirre GD, Gross SL, Diters RW. Choroidal melanomas in dogs. Vet Pathol. 1985;22(6):582-5. https://doi.org/10.1177/030098588502200612. PMid:4082384.
Galán A, Martín-Suárez EM, Molleda JM, Raya A, Gómez-Laguna J, Martín De Las Mulas J. Presumed primary uveal melanoma with brain extension in a dog. J Small Anim Pract. 2009;50(6):306-10. https://doi.org/10.1111/j.1748-5827.2009.00721.x. PMid:19527424.
Gillard M, Cadieu E, De Brito C, Abadie J, Vergier B, Devauchelle P, Degorce F, Dréano S, Primot A, Dorso L, Lagadic M, Galibert F, Hédan B, Galibert MD, André C. Naturally occurring melanomas in dogs as models for non-UV pathways of human melanomas. Pigment Cell Melanoma Res. 2014;27(1):90-102. https://doi.org/10.1111/pcmr.12170. PMid:24112648.
Hase K, Kase S, Kanda A, Shinmei Y, Noda K, Ishida S. Expression of vascular endothelial growth factor-c in the trabecular meshwork of patients with neovascular glaucoma and primary open-angle glaucoma. J Clin Med. 2021;10(13):2977. https://doi.org/10.3390/jcm10132977. PMid:34279462.
Lemetayer J, Al-Dissi A, Tryon K, MacDonald-Dickinson V. Primary intranasal melanoma with brain invasion in a dog. Can Vet J. 2017;58(4):391-6. PMid:28373733.
Ma X, Li H, Chen Y, Yang J, Chen H, Arnheiter H, Hou L. The transcription factor MITF in RPE function and dysfunction. Prog Retin Eye Res. 2019;73:100766. https://doi.org/10.1016/j.preteyeres.2019.06.002. PMid:31242455.
Maggs DJ, Miller PE, Ofri R. Slatter’s fundamentals of veterinary ophthalmology. 5th ed. Paris: Saunders; 2015.
Malho P, Shea A, Donaldson D. Nevus of Ota (oculodermal melanocytosis) in a dog. Vet Ophthalmol. 2018;21(3):312-8. https://doi.org/10.1111/vop.12489. PMid:28745006.
Miwa Y, Matsunaga S, Kato K, Ogawa H, Nakayama H, Tsujimoto S, Sasaki N. Choroidal melanoma in a dog. J Vet Med Sci. 2005;67(8):821-3. https://doi.org/10.1292/jvms.67.821. PMid:16141671.
Nishiya AT, Massoco CO, Felizzola CR, Perlmann E, Batschinski K, Tedardi MV, Garcia JS, Mendonça PP, Teixeira TF, Zaidan Dagli ML. Comparative aspects of canine melanoma. Vet Sci. 2016;3(1):7. https://doi.org/10.3390/vetsci3010007. PMid:29056717.
Perlmann E. Estudo imunoistoquímico das neoplasias melanocíticas uveais em cães [tese]. São Paulo: Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia; 2015. https://doi.org/10.11606/T.10.2016.tde-03092015-173006.
Perlmann E. Estudo morfológico das neoplasias melanocíticas uveais em cães [dissertação]. São Paulo: Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia; 2010. https://doi.org/10.11606/D.10.2010.tde-27012012-101434.
Prouteau A, André C. Canine melanomas as models for human melanomas: clinical, histological, and genetic comparison. Genes. 2019;10(7):501. https://doi.org/10.3390/genes10070501. PMid:31262050.
Sahu S, Bhutia TW, Shrestha V, Singh SK, Puri LR. Large choroidal melanoma presenting as neovascular glaucoma. GMS Ophthalmol Cases. 2019;9:Doc19. PMid:31293875.
Schoster JV, Dubielzig RR, Sullivan L. Choroidal melanoma in a dog. J Am Vet Med Assoc. 1993;203(1):89-91. PMid:8407467.
Starkey MP, Compston-Garnett L, Malho P, Dunn K, Dubielzig R. Metastasis-associated microRNA expression in canine uveal melanoma. Vet Comp Oncol. 2018;16(1):81-9. https://doi.org/10.1111/vco.12315. PMid:28512868.
van der Weyden L, Brenn T, Patton EE, Wood GA, Adams DJ. Spontaneously occurring melanoma in animals and their relevance to human melanoma. J Pathol. 2020;252(1):4-21. https://doi.org/10.1002/path.5505. PMid:32652526.
Wang AL, Kern T. Melanocytic ophthalmic neoplasms of the domestic veterinary species: a review. Top Companion Anim Med. 2015;30(4):148-57. https://doi.org/10.1053/j.tcam.2015.06.001. PMid:27154598.
Zoroquiain P, Mayo-Goldberg E, Alghamdi S, Alhumaid S, Perlmann E, Barros P, Mayo N, Burnier MN Jr. Melanocytoma-like melanoma may be the missing link between benign and malignant uveal melanocytic lesions in humans and dogs: a comparative study. Melanoma Res. 2016;26(6):565-71. https://doi.org/10.1097/CMR.0000000000000297. PMid:27571324.
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