The effect of prostaglandin F2alfa on false pregnancy in bitches

Abstract

The property of Prostaglandin F₂alfa Tham-salt to induce functional regression of the corpus luteum was investigated in 40 clinically false pregnant bitches of various breed and age. PGF₂alfa was administered by subcutaneous injection of 0.5 mg, being effective in 37 animals, but had to be repeated in 4 cases. Animals reached normal behaviour in about 7 to 8 days after treatment. Vomiting and anorexy were observed in one bitch and sleepiness in as many three. The implications of the persistent corpora lutea in relation to the luteolytic effect of PGF₂alfa in false pregnant bitches is discussed. Results suggest that PGF₂alfa could be used for termination of clinical symptoms of canine false pregnancies. No methods of radioimmunoassay or competitive protein binding are available for LH and progesterone analyses.