Fingernails as a biomarker for dental fluorosis

Autores

  • Lilian Rigo Professor, Department of Dentistry, Faculdade Meridional / IMED, Passo Fundo (RS)
  • Graziela Oro Cericato Professor, Department of Dentistry, Faculdade Meridional / IMED, Passo Fundo (RS)
  • Clarice Sagin Sabadin Professor, Department of Dentistry, Faculdade Meridional / IMED, Passo Fundo (RS)
  • Caroline Solda Lutheran University of Brazil, Canoas (RS),
  • Débora Nunes Mário Professor, Department of Dentistry, Faculdade Meridional / IMED, Passo Fundo (RS)
  • Marília Afonso Rabelo Buzalaf Professor, Department of Dentistry, School of Dentistry of Bauru (FOB/ Bauru), Bauru (SP)

DOI:

https://doi.org/10.7322/jhgd.133582

Palavras-chave:

Fluoride poisoning, Fluoride, Biological marker, Dental tooth fluorosis

Resumo

Introduction: Biomarkers indicate levels of a particular chemical agent in the environment studied, which may be useful for monitoring health status, and nails may be major indicators of fluoride.

Objective: To evaluate fluoride concentration in the fingernails of children as a biomarker for fluoride exposure.

Methods: Twenty students were selected, aged 4-5 years old. Their nails were cut at 15 and 45 days (two collections), and the fluoride concentration in the nails was analyzed with the ion-specific electrode (Orion 9409) after rapid diffusion with HDMS.

Results: The total fluoride mean of the samples was 3.68 μg F/g (sd 1.44), ranging from 1.39 μg F/g to 7.81 μg F/g. Eleven children (55%) brush their teeth three times a day, but only three children (15%) swallow toothpaste.

Conclusion: There is a high prevalence of fluoride exposure in the fingernails of the children studied, presenting risk of developing dental fluorosis in permanent teeth.


Downloads

Os dados de download ainda não estão disponíveis.

Referências

Carey CM. Focus on fluorides: update on the use of fluoride for the prevention of dental caries. J Evid Based Dent Pract.. 2014;14(Suppl:95-102). DOI: http://dx.doi.org/10.1016/j.jebdp.2014.02.004

Dean HT. Classification of mottled enamel diagnosis. J Amer Dent Assoc. 1934;21(8):1421-6. DOI: https://doi.org/10.14219/jada.archive.1934.0220

Moseley R, Waddington RJ, Sloan AJ, Smith AJ, Hall RC, Embery G. The influence of fluoride exposure on dentin mineralization using an in vitro organ culture model. Calcif Tissue Int. 2003;73(5):470-5. DOI: http://dx.doi.org/10.1007/s00223-003-0022-8

Carvalho RB, Medeiros UV, Santos KT, Pacheco Filho AC. Influence of different concentrations of fluoride in the water on epidemiologic indicators of oral health/disease. Cienc Saude Coletiva. 2011;16(8):3509-18. DOI: http://dx.doi.org/10.1590/S1413-81232011000900019

Buzalaf MA, Pessan JP, Alves KM. Influence of growth rate and length on fluoride detection in human nails. Caries Res. 2006;40(3):231-8. DOI: http://dx.doi.org/10.1159/000092231

Khairnar MR, Dodamani AS, Jadhav HC, Naik RG, Deshmukh MA. Mitigation of Fluorosis – A review. J Clin Diagn Res. 2015;9(6):ZE05-9. DOI: http://dx.doi.org/10.7860/JCDR/2015/13261.6085

Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Projeto SB Brasil 2010: Condições de saúde bucal da população brasileira 2009-2010: resultados principais. Brasília: Ministério da Saúde; 2011.

Maltz M, Silva BB, Schaeffer A, Farias C. Prevalência de fluorose em duas cidades brasileiras, uma com água artificialmente fluoretada e outra com baixo teor de flúor, em 1987 e 1997/98. Rev Fac Odontol Porto Alegre. 2000;41(2):51-5.

Narvai PC, Antunes JLF, Frias AC, Soares MC, Marques RAA, Teixeira DSC, et al. Fluorose dentária em crianças de São Paulo, SP, 1998-2010. Rev Saúde Pública. 2013;47(Supll.3):148-53. DOI: http://dx.doi.org/10.1590/S0034-8910.2013047004715

Rigo L, Caldas Junior AF, Souza EHA. Factors associated with dental fluorosis. Rev Odonto Ciênc. 2010;25(1):8-14. DOI: http://dx.doi.org/10.1590/S1980-65232010000100003

Rigo L, Sabadin CS, Wietholter P, Solda C, Flores R. Prevalência de fluorose dentária em crianças de uma escola municipal de Passo Fundo/RS. Full Dentistry Sci. 2014;5(19):472-6.

Jordão LMR, Vasconcelos DN, Moreira RS, Freire MCM. Dental fluorosis: prevalence and associated factors in 12-year-old schoolchildren in Goiânia, Goiás. Rev Bras Epidemiol. 2015; 18(3):568-77. DOI: http://dx.doi.org/10.1590/1980-5497201500030004

Amorim LCA. Os biomarcadores e sua aplicação na avaliação da exposição aos agentes químicos ambientais. Rev Bras Epidemiol. 2003;6(2):158-70. DOI: http://dx.doi.org/10.1590/S1415-790X2003000200009

Fukushima R, Rigolizzo DS, Maia LP, Sampaio FC, Lauris JR, Buzalaf MA. Environmental and individual factors associated with nail fluoride concentration. Caries Res. 2009;43(2):147-54. DOI: http://dx.doi.org/10.1159/000211718

Buzalaf MA, Massaro CS, Rodrigues MH, Fukushima R, Pessan JP, Whitford GM, et al. Validation of fingernail fluoride concentration as a predictor of risk for dental fluorosis. Caries Res. 2012;46(4):394-400. DOI: http://dx.doi.org/10.1159/000339088

Levy FM, Bastos JR, Buzalaf MA. Nails as biomarkers of fluoride in children of fluoridated communities. J Dent Child. 2004;71(2):121-5.

Taves DR. Separation of fluoride by rapid diffusion using hexamethyldisiloxane. Talanta. 1968; 15(9):969-74.

Rigo L, Caldas-Junior AF, Souza EA, Abegg C, Lodi L. Estudo sobre a fluorose dentária num município do sul do Brasil. Cien Saude Colet. 2010;15(Supl.1):1439-48. DOI: http://dx.doi.org/10.1590/S1413-81232010000700055

Brito CS, Garbin RR, Mussi A, Rigo L. Vigilância da concentração de flúor nas águas de abastecimento público na cidade de Passo Fundo - RS. Cad Saúde Coletiva. 2016;24(4):452-9. DOI: 10.1590/1414-462X201600040240

Lima-Arsati YBO, Martins CC, Rocha LA, Cury JA. Fingernail may not be a reliable biomarker of fluoride body burden from dentifrice. Braz Dent J. 2010;21(2):91-7. DOI: http://dx.doi.org/10.1590/S0103-64402010000200001

Pessan JP, Buzalaf MR. Historical and recent biological markers of exposure to fluoride. Monogr Oral Sci. 2011;22:52-65. DOI: http://dx.doi.org/10.1159/000325145

Whitford GM, Sampaio FC, Arneberg P, von der Fehr FR. Fingernail fluoride: a method for monitoring fluoride exposure. Caries Res. 1999;33(6):462-7. DOI: http://dx.doi.org/10.1159/000016552

Amaral JG, Freire IR, Valle-Neto EFR, Cunha RF, Martinhon CCR, Delbem ACB. Longitudinal evaluation of fluoride levels in nails of 18–30-month-old children that were using toothpastes with 500 and 1100 µg F/g. Community Dent Oral Epidemiol. 2014;42(5):412-9.

Buzalaf MA, Rodrigues MH, Pessan JP, Leite AL, Arana A, Villena RS, et al. Biomarkers of fluoride in children exposed to different sources of systemic fluoride. J Dent Res. 2011;90(2):215-9. DOI: http://dx.doi.org/10.1177/0022034510385937

Villena RS. An investigation of the transverse technique of dentifrice application to reduce the amount of fluoride dentifrice for young children. Pediatr Dent. 2000;22(4):312-7.

Vilhena FV, Silva HM, Peres S, Carvalho SH, Caldana ML, Buzalaf MAR. The drop technique: a method to control the amount of fluoride dentifrice used by young children. Oral Health Prev Dent. 2008 6(1):61-5.

Cury JA, Caldarelli PG, Tenuta LMA. Necessity to review the Brazilian regulation about fluoride toothpastes. Rev Saude Publica. 2015;49:1-7. DOI: http://dx.doi.org/10.1590/S0034-8910.2015049005768

Publicado

2018-03-12

Edição

Seção

Artigos Originais