The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats

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DOI:

https://doi.org/10.1590/

Keywords:

Apical periodontitis, Stemregen, Host modulation, Rat

Abstract

This study evaluated the effect of Stemregen® nutritional supplement on inflammation and resorption in apical periodontitis using a rat model. Methodology  Rats were divided in three groups: negative control (n=7), positive control (n=10), and Stemregen® (Stem) (n=10). Apical periodontitis was induced in the positive control and Stem groups, and all rats were sacrificed on the 30th day. Serum phosphorus (P), calcium (Ca), and alkaline phosphatase (ALP) were analyzed. Histopathological assessments measured osteoblastic and osteoclastic activity, inflammation, fibrosis, and abscess density. Immunohistochemical analyses evaluated RANKL, TRAP, and OPG levels. Results  Results showed significantly lower osteoblastic activity in the negative control compared to Stem and positive control groups (p=0.005). Osteoclastic activity was higher in the positive control (p=0.032). Inflammation and abscess formation were reduced in the Stem group compared to the positive control (p<0.001). OPG levels were lower in the negative control compared to the other groups (p=0.005). Conclusion  Stemregen® effectively reduced inflammation and bone destruction, suggesting potential benefits for apical periodontitis management, though further research is needed.

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Published

2025-02-03

Issue

Vol. 33 (2025)

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Original Articles

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Copyright (c) 2025 Fatma Gönüllü, Mevlüt Sinan Ocak, Serkan Dunkar, İbrahim Hanifi Özercan

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How to Cite

Gönüllü, F., Ocak, M. S., Dunkar, S., & Özercan, İbrahim H. (2025). The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats. Journal of Applied Oral Science, 33, e20240446. https://doi.org/10.1590/