Bleaching as a complement to fluoride-enhanced remineralization or resin infiltration in masking white spot lesions

Authors

DOI:

https://doi.org/10.1590/1678-7757-2024-0097

Keywords:

Color, Fluoride, Resin infiltration

Abstract

There are many suitable strategies for addressing caries, which is an ongoing worldwide problem. Although white spot lesions (WSLs) can be either remineralized naturally or treated with non- or micro-invasive strategies, their whitish and opaque appearance may persist. Objective: To evaluate the effects of tooth bleaching as a complement to fluoride-enhanced remineralization or resin infiltration in masking WSLs, as well as in enamel surface roughness relative to that of the adjacent enamel. Methodology: Flattened rectangular bovine enamel fragments (6×3×~2.9 mm length, width and thickness) were divided into six groups (L/N, F/N, F.BL/BL, I/N, I.BL/BL, N/N; n=15). Treatments applied to the 3×3 mm left half included: L (Lesion) - WSL simulation with 50 mM acetate buffer, 96 hours, 37ºC; F (Fluoride) - WSL treatment with 2% NaF neutral gel, 1x/week, 8 weeks; I (Infiltration) - WSL treatment with H3PO4 37%/10 s; Icon®-Dry/30 s; Icon®-Infiltrant/3 min+1 min; N (Nothing) - sound enamel/control. Treatments applied to both halves after F and I included: BL (Bleaching) - Opalescence Boost 40%, 3×/20 min each; N (Nothing) - control. The differences in color (ΔE00, ΔL, Δa, Δb) and surface roughness (ΔRa) between the left and right halves were measured. Kruskal-Wallis/post-hoc tests were applied to ΔE00, ΔL, Δa and ΔRa, and 1-way ANOVA/Tukey tests to Δb (α=0.05). Results: The factor under study significantly influenced ΔE00 (p=0.0001), ΔL (p=0.0024), Δb (p=0.0015), and ΔRa (p<0.001), but not Δa (p=0.1592). Both fluoride-enhanced remineralization and resin infiltration were able to mask WSL, regardless of subsequent bleaching. However, when bleaching was performed, ΔE00 median values did not exceed the acceptability threshold for color difference. Only resin infiltration reduced ΔRa between WSL and the adjacent enamel. Conclusions: Both remineralization and infiltration, particularly if complemented by bleaching, fostered satisfactory esthetic results. Only infiltration without bleaching led to really good results in surface roughness.

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References

- Qin X, Zi H, Zeng X. Changes in the global burden of untreated dental caries from 1990 to 2019: a systematic analysis for the Global Burden of Disease study. Heliyon. 2022;8(9):e10714. doi: 10.1016/j.heliyon.2022.e10714

- Schwendicke F, Splieth C, Breschi L, Banerjee A, Fontana M, Paris S, et al. When to intervene in the caries process? An expert Delphi consensus statement. Clin Oral Investig. 2019;23(10):3691-703. doi: 10.1007/s00784-019-03058-w

- Kidd EA, Fejerskov O. What constitutes dental caries? Histopathology of carious enamel and dentin related to the action of cariogenic biofilms. J Dent Res. 2004;83 Spec No C:C35-8. doi: 10.1177/154405910408301s07

- Maxfield BJ, Hamdan AM, Tüfekçi E, Shroff B, Best AM, Lindauer SJ. Development of white spot lesions during orthodontic treatment: perceptions of patients, parents, orthodontists, and general dentists. Am J Orthod Dentofacial Orthop. 2012;141(3):337-44. doi: 10.1016/j.ajodo.2011.08.024

- Araújo GS, Naufel FS, Alonso RC, Lima DA, Puppin-Rontani RM. Influence of staining solution and bleaching on color stability of resin used for caries infiltration. Oper Dent. 2015;40(6):E250-6. doi: 10.2341/14-290-L

- Urquhart O, Tampi MP, Pilcher L, Slayton RL, Araujo MW, Fontana M, et al. Nonrestorative treatments for caries: systematic review and network meta-analysis. J Dent Res. 2019;98(1):14-26. doi: 10.1177/0022034518800014

- Jones RS, Fried D. Remineralization of enamel caries can decrease optical reflectivity. J Dent Res. 2006;85(9):804-8. doi: 10.1177/154405910608500905

- Paris S, Meyer-Lueckel H, Kielbassa AM. Resin infiltration of natural caries lesions. J Dent Res. 2007;86(7):662-6. doi: 10.1177/154405910708600715

- Paris S, Meyer-Lueckel H. Masking of labial enamel white spot lesions by resin infiltration: a clinical report. Quintessence Int. 2009;40(9):713-8.

- Borges AB, Caneppele TM, Masterson D, Maia LC. Is resin infiltration an effective esthetic treatment for enamel development defects and white spot lesions? A systematic review. J Dent. 2017;56:11-8. doi: 10.1016/j.jdent.2016.10.010

- Carvalho GG, Pires AC, Sousa FB. Influence of infiltrant application time on the reduction of opaqueness of proximal enamel caries. Indian J Dent Res. 2019;30(1):52-6. doi: 10.4103/ijdr.IJDR_267_17

- Freitas PM, Basting RT, Rodrigues JA, Serra MC. Effects of two 10% peroxide carbamide bleaching agents on dentin microhardness at different time intervals. Quintessence Int. 2002;33(5):370-5.

- Schoppmeier CM, Derman SH, Noack MJ, Wicht MJ. Power bleaching enhances resin infiltration masking effect of dental fluorosis: a randomized clinical trial. J Dent. 2018;79:77-84. doi: 10.1016/j.jdent.2018.10.005

- Cunha LF, Silva VB, Garcia FC, Roskamp L, Matos TP, Madalena IR, et al. Treatment protocol of dental bleaching and resin infiltration for white spot lesions. Int J Esthet Dent. 2023;18(2):200-6.

- Jacob SE, Varghese JO, Singh S, Natarajan S, Thomas MS. Effect of bleaching on color and surface topography of teeth with enamel caries treated with resin infiltration (ICON ® ) and remineralization (casein phosphopeptide-amorphous calcium phosphate). J Conserv Dent Endod. 2023;26(4):377-82. doi: 10.4103/jcd.jcd_129_23

- Sinanovic AL, Messer-Hannemann P, Samadi M, Schwendicke F, Effenberger S. Effect of bleaching on resin-infiltration-masked artificial white spots in vitro. J Funct Biomater. 2024;15(5):125. doi: 10.3390/jfb15050125

- Kim S, Kim EY, Jeong TS, Kim JW. The evaluation of resin infiltration for masking labial enamel white spot lesions. Int J Paediatr Dent. 2011;21(4):241-8. doi: 10.1111/j.1365-263X.2011.01126.x

- Mazur M, Westland S, Guerra F, Corridore D, Vichi M, Maruotti A, et al. Objective and subjective aesthetic performance of icon® treatment for enamel hypomineralization lesions in young adolescents: a retrospective single center study. J Dent. 2018;68:104-8. doi: 10.1016/j.jdent.2017.11.001

- Paravina RD, Ghinea R, Herrera LJ, Bona AD, Igiel C, Linninger M, et al. Color difference thresholds in dentistry. J Esthet Restor Dent. 2015;27 Suppl 1:S1-9. doi: 10.1111/jerd.12149

- Ávila DM, Zanatta RF, Scaramucci T, Aoki IV, Torres CR, Borges AB. Influence of bioadhesive polymers on the protective effect of fluoride against erosion. J Dent. 2017;56:45-52. doi: 10.1016/j.jdent.2016.10.015

- Queiroz CS, Hara AT, Leme AF, Cury JA. pH-cycling models to evaluate the effect of low fluoride dentifrice on enamel de- and remineralization. Braz Dent J. 2008;19(1):21-7. doi: 10.1590/s0103-64402008000100004

- Magalhães AC, Moron BM, Comar LP, Wiegand A, Buchalla W, Buzalaf MA. Comparison of cross-sectional hardness and transverse microradiography of artificial carious enamel lesions induced by different demineralising solutions and gels. Caries Res. 2009;43(6):474-83. doi: 10.1159/000264685

- Santos DM, Pires JG, Silva AB, Salomão PM, Buzalaf MA, Magalhães AC. Protective effect of 4% titanium tetrafluoride varnish on dentin demineralization using a microcosm biofilm model. Caries Res. 2019;53(5):576-83. doi: 10.1159/000499317

- Göhring TN, Zehnder M, Sener B, Schmidlin PR. In vitro microleakage of adhesive-sealed dentin with lactic acid and saliva exposure: a radio-isotope analysis. J Dent. 2004;32(3):235-40. doi: 10.1016/j.jdent.2003.11.003

- Torres CR, Borges AB, Torres LM, Gomes IS, Oliveira RS. Effect of caries infiltration technique and fluoride therapy on the colour masking of white spot lesions. J Dent. 2011;39(3):202-7. doi: 10.1016/j.jdent.2010.12.004

- Torres CR, Zanatta RF, Fonseca BM, Borges AB. Fluorescence properties of demineralized enamel after resin infiltration and dental bleaching. Am J Dent. 2019;32(1):43-6.

- Bak SY, Kim YJ, Hyun HK. Color change of white spot lesions after resin infiltration. Color Res. 2014;39:506-10. doi: 10.1002/col.21821

- Youssef AS, Covell DA Jr, Makowka S, Gailey A, Dunford RG, Al-Jewair T, et al. Comparison of bleaching effects when applied to white-spot lesions before or after resin infiltration: an in vitro study. J Am Dent Assoc. 2022;153(1):39-49. doi: 10.1016/j.adaj.2021.07.017

- Holmen L, Thylstrup A, Ogaard B, Kragh F. A scanning electron microscopic study of progressive stages of enamel caries in vivo. Caries Res. 1985;19(4):355-67. doi: 10.1159/000260867

- Rocha RS, Souza MY, Meirelles LC, Scarense CG, Diniz MB, Caneppele TM, et al. Effectiveness of home bleaching treatment after resin infiltrant application. Oral Health Prev Dent. 2020;18(1):549-54. doi: 10.3290/j.ohpd.a44691

- Marinho VC. Cochrane reviews of randomized trials of fluoride therapies for preventing dental caries. Eur Arch Paediatr Dent. 2009;10(3):183-91. doi: 10.1007/BF03262681

- Brodbelt RH, O'Brien WJ, Fan PL, Frazer-Dib JG, Yu R. Translucency of human dental enamel. J Dent Res. 1981;60(10):1749-53. doi: 10.1177/00220345810600100401

- Auschill TM, Schmidt KE, Arweiler NB. Resin infiltration for aesthetic improvement of mild to moderate fluorosis: a six-month follow-up case Report. Oral Health Prev Dent. 2015;13(4):317-22. doi: 10.3290/j.ohpd.a32785

- Levrini L, Paracchini L, Bakaj R, Diaconu A, Cortese S. Dental bleaching during orthodontic treatment with aligners. Int J Esthet Dent. 2020;15(1):44-54.

- Soveral M, Machado V, Botelho J, Mendes JJ, Manso C. Effect of resin infiltration on enamel: a systematic review and meta-analysis. J Funct Biomater. 2021;12(3):48. doi: 10.3390/jfb12030048

- Mueller J, Yang F, Neumann K, Kielbassa AM. Surface tridimensional topography analysis of materials and finishing procedures after resinous infiltration of subsurface bovine enamel lesions. Quintessence Int. 2011;42(2):135-47.

- Wang L, Francisconi LF, Atta MT, Santos JR, Del Padre NC, Gonini A Jr, et al. Effect of bleaching gels on surface roughness of nanofilled composite resins. Eur J Dent. 2011;5(2):173-9.

- Pinelli MD, Catelan A, Resende LF, Soares LE, Aguiar FH, Liporoni PC. Chemical composition and roughness of enamel and composite after bleaching, acidic beverages and toothbrushing. J Clin Exp Dent. 2019;11(12):e1175-80. doi: 10.4317/jced.56442

- Meyer-Lueckel H, Chatzidakis A, Naumann M, Dörfer CE, Paris S. Influence of application time on penetration of an infiltrant into natural enamel caries. J Dent. 2011;39(7):465-9. doi: 10.1016/j.jdent.2011.04.003

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Published

2024-09-27 — Updated on 2024-10-01

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How to Cite

Pereira, T. P., Landmayer, K., Iatarola, B. de O., Vertuan, M., Magalhães, A. C., & Francisconi-dos-Rios, L. F. (2024). Bleaching as a complement to fluoride-enhanced remineralization or resin infiltration in masking white spot lesions. Journal of Applied Oral Science, 32, e20240097. https://doi.org/10.1590/1678-7757-2024-0097 (Original work published 2024)