How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

Authors

  • Renata Miranda Rodrigues Universidade Federal Fluminense, Programa de Graduação em Odontologia, Niterói, Rio de Janeiro
  • Vagner Gonçalves Bernardo Universidade Estadual do Rio de Janeiro (UERJ), Departamento de Bioquímica, Rio de Janeiro, Rio de Janeiro
  • Sabrina Daniela da Silva Segal Cancer Centre, Department of Otolaryngology, Head and Neck Surgery; Sir Mortimer B. Davis-Jewish General Hospital, Lady Davis Institute for Medical Research, Montréal
  • Danielle Resende Camisasca Universidade Federal do Espírito Santo, Departamento de Patologia Oral, Vitória, Espírito Santo
  • Paulo Antônio de Silvestre Faria Instituto Nacional de Câncer (INCA), Divisão de Patologia, Rio de Janeiro, Rio de Janeiro
  • Fernando Luiz Dias Instituto Nacional de Câncer (INCA), Departamento de Cirurgia de Cabeça e Pescoço, Rio de Janeiro, Rio de Janeiro
  • Luís Felipe Ribeiro Pinto Instituto Nacional de Câncer (INCA), Centro de Pesquisas, Programa de Carcinogênese Molecular.
  • Rodolpho Mattos Albano Universidade Estadual do Rio de Janeiro (UERJ), Departamento de Bioquímica, Rio de Janeiro, Rio de Janeiro
  • Anke Bergmann Instituto Nacional de Câncer (INCA), Centro de Pesquisas, Programa de Carcinogênese Molecular.
  • Simone de Queiroz Chaves Lourenço Universidade Federal Fluminense, Programa de Graduação em Odontologia, Niterói, Rio de Janeiro

DOI:

https://doi.org/10.1590/1678-7757-2019-0198

Keywords:

Oral cancer, Squamous cell carcinoma, Prognosis, Survival, Oral pathology

Abstract

Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. Objective: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). Methodology: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). Results: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. Conclusion: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC.

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Published

2021-06-14

Issue

Vol. 28 (2020)

Section

Original Articles

License

Copyright (c) 2021 Journal of Applied Oral Science

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons do tipo atribuição CC-BY.

 

 

How to Cite

Rodrigues, R. M. ., Bernardo, V. G. ., Silva, S. D. da, Camisasca, D. R. ., Faria, P. A. de S. ., Dias, F. L. ., Pinto, L. F. R. ., Albano, R. M. ., Bergmann, A. ., & Lourenço, S. de Q. C. . (2021). How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma. Journal of Applied Oral Science, 28, e20190198. https://doi.org/10.1590/1678-7757-2019-0198