Motor development in non-microcephalic infants born to mothers with Zika Virus infection during pregnancy

Authors

DOI:

https://doi.org/10.1590/1809-2950/19015227022020

Keywords:

Zika Virus, Child Development, Physiotherapy, Brazil

Abstract

This cross-sectional study sought to evaluate motor development in infants exposed to ZIKV born with normal head circumference (HC). Thirty one children, distributed into two groups, participated in the study: 15 whose mothers were infected by ZIKV during pregnancy, born with HC from −1.9 to +2 Z-scores, adjusted for sex and gestational age (exposed group); and 16 randomly selected infants without known prenatal exposure to ZIKV, paired by sex and age (control group). Alberta Infant Motor Scale (AIMS) was used to evaluate gross motor development. We found no significant difference between the exposed and control groups. However, considering that AIMS is a screening test that assesses only the gross motor development and the small size of our sample, infants exposed to ZIKV during pregnancy should be continuously evaluated for different aspects of their development.

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References

Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR. Zika

Virus and birth defects-reviewing the evidence for causality. N

Engl J Med. 2016;374(20):1981-7. doi: 10.1056/NEJMsr1604338

Schuler-Faccini L, Sanseverino MTV, Vianna FSL, Silva AA,

Larrandaburu M, Marcolongo-Pereira C, et al. Zika Virus: a new

human teratogen? Implications for women reproductive age.

Clin Pharmacol Ther. 2016;100(1):28-30. doi: 10.1002/cpt.386

Schuler-Faccini L, Ribeiro EM, Feitosa IML, Horovitz DDG,

Cavalcanti DP, Pessoa A, et al. Possible Association Between

Zika Virus Infection and Microcephaly – Brazil, 2015. Morb Mortal

Wkly Rep. 2016;65(3):59-62. doi: 10.15585/mmwr.mm6503e2

Russell LJ, Weaver DD, Bull MJ, Weinbaum M, Opitz JM. In

utero brain destruction resulting in collapse of the fetal skull,

microcephaly, scalp rugae, and neurologic impairment: the

fetal brain disruption sequence. Am J Med Genet. 1984;17(2):

-21. doi: 10.1002/ajmg.1320170213

Moore CA, Staples JE, Dobyns WB, Pessoa A, Ventura CV,

Fonseca EB, et al. Characterizing the pattern of anomalies in

congenital Zika syndrome for pediatric clinicians. JAMA Pediatr.

;171(3):288-95. doi: 10.1001/jamapediatrics.2016.3982

Del Campo M, Feitosa IM, Ribeiro EM, Horovitz DD, Pessoa AL,

França GV, et al. The phenotypic spectrum of congenital Zika

syndrome. Am J Med Genet A. 2017;173(4):841-57. doi: 10.1002/

ajmg.a.38170

Aragao M, Holanda AC, Brainer-Lima AM, Petribu NCL, Castillo

M, Van der Linden V, et al. Nonmicrocephalic Infants with

Congenital Zika Syndrome Suspected Only after Neuroimaging

Evaluation Compared with Those with Microcephaly at Birth

and Postnatally: How Large Is the Zika Virus “Iceberg”? AJNR

Am J Neuroradiol. 2017;38(7):1427-34. doi: 10.3174/ajnr.A5216

Van der Linden V, Pessoa A, Dobyns W, Barkovich AJ, Van der

Linden H Jr, Rolim Filho EL, et al. Description of 13 Infants Born

During October 2015-January 2016 With Congenital Zika Virus

Infection Without Microcephaly at Birth – Brazil. MMWR Morb

Mortal Wkly Rep. 2016;65(47):1343-8. doi: 10.15585/mmwr.

mm6547e2

Zin AA, Tsui I, Rossetto J, Vasconcelos Z, Adachi K, Valderramos

S, et al. Screening criteria for ophthalmic manifestations of

congenital Zika virus infection. JAMA Pediatr. 2017;171(9):847-54.

doi: 10.1001/jamapediatrics.2017.1474

Honein MA, Dawson AL, Petersen EE, Jones AM, Lee

EH, Yazdy MM, et al. Birth Defects Among Fetuses and

Infants of US Women With Evidence of Possible Zika Virus

Infection During Pregnancy. JAMA. 2017;317(1):59-68. doi:

1001/jama.2016.19006

Babenko O, Kovalchuk I, Metz GA. Stress-induced perinatal

and transgenerational epigenetic programming of brain

development and mental health. Neurosci Biobehav Rev.

;48:70-91. doi: 10.1016/j.neubiorev.2014.11.013

Cabral J, Faiçal A, Almeida B, Oliveira JV, Embiruçu E, Ferreira, N,

et al. Neurodevelopmental delays arising from in utero exposure

to Zika virus in Salvador, Brazil. Int J Infect Dis. 2018;73:48-9.

doi: 10.1016/j.ijid.2018.04.3533

Cardoso TF Jr, Santos RSD, Corrêa RM, Campos JV, Silva RB,

Tobias CC, et al.Congenital Zika infection: neurology can occur

without microcephaly. Arch Dis Child. 2019;104(2):199-200.

doi: 10.1136/archdischild-2018-314782

Faiçal AV, Oliveira JC, Oliveira JVV, Almeida BL, Agra IA, Alcantara

LCJ, et al. Neurodevelopmental delay in normocephalic children

with in utero exposure to Zika virus. BMJ Paediatr Open.

;3(1):e000486. doi: 10.1136/bmjpo-2019-000486

Piper MC, Darrah J. Motor assessment of the developing infant.

Philadelphia: Saunders; 1994.

Valentini NC, Pereira KRG, Santos Chiquetti EM, Formiga

CKMR, Linhares MBM. Motor trajectories of preterm and

full-term infants in the first year of life. Pediatr Int. 2019. doi:

1111/ped.13963

Botelho ACG, Neri LV, Silva MQF, Lima TT, Santos KG,

Cunha RMA, et al. Presumed congenital infection by Zika

virus: findings on psychomotor development-a case

report. Rev Bras Saúde Matern Infant. 2016;16(1):39-44.

doi: 10.1590/1806-9304201600s100004

Flor CJDRV, Guerreiro CF, Anjos JLM. Desenvolvimento

neuropsicomotor em crianças com microcefalia associado

ao Zika Vírus. Rev Pesqui Fisioter. 2017;7(3):313-8. doi:

17267/2238-2704rpf.v7i3.1386

Melo A, Gama GL, Silva RA Jr, Assunção PL, Tavares JS, Silva MB

et al. Motor function in children with congenital Zika syndrome.

Dev Med Child Neurol. 2019; 62(2):221-6. doi: 10.1111/dmcn.14227

Ferreira HNC, Schiariti V, Regalado ICR, Sousa KG, Pereira SA,

Fechine CPNDS, et al. Functioning and Disability Profile of

Children with Microcephaly Associated with Congenital Zika

Virus Infection. Int J Environ Res Public Health. 2018;15(6):1107.

doi: 10.3390/ijerph15061107

Krow-Lucal ER, Andrade MR, Cananéa JNA, Moore CA, Leite

PL, Biggerstaff BJ, et al. Association and birth prevalence

of microcephaly attributable to Zika virus infection

among infants in Paraíba, Brazil, in 2015-16: a case-control

study. Lancet Child Adolesc Health. 2018;2(3):205-13. doi:

1016/S2352-4642(18)30020-8

Castro MC, Han QC, Carvalho LR, Victora CG, França GVA.

Implications of Zika virus and congenital Zika syndrome for

the number of live births in Brazil. Proc Natl Acad Sci USA.

;115(24):6177-82. doi: 10.1073/pnas.1718476115

Paul AM, Acharya D, Neupane B, Thompson EA, GonzalezFernandez G, Copeland KM, et al. Congenital Zika Virus

Infection in Immunocompetent Mice Causes Postnatal Growth

Impediment and Neurobehavioral Deficits. Front Microbiol.

;9:2028. doi: 10.3389/fmicb.2018.02028

Brasil P, Pereira JP Jr, Moreira ME, Ribeiro Nogueira RM,

Damasceno L, Wakimoto M, et al. Zika virus infection in pregnant

women in Rio de Janeiro. N Engl J Med.2016;375(24):2321-34.

doi: 10.1056/NEJMoa1602412

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Published

2020-03-03

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Original Research

How to Cite

Motor development in non-microcephalic infants born to mothers with Zika Virus infection during pregnancy. (2020). Fisioterapia E Pesquisa, 27(2), 174-179. https://doi.org/10.1590/1809-2950/19015227022020