Granular Cell Tumor on the soft palate: a very rare location

Authors

  • Willian Pecin Jacomacci State University of Maringa

DOI:

https://doi.org/10.11606/issn.2357-8041.clrd.2015.96108

Keywords:

Granular Cell Tumor, Differential Diagnosis

Abstract

Granular cell tumor (GCT) is a rare lesion of neural origin and uncertain nature. It can be a true neoplasm, a degenerative metabolic process or a proliferation trauma-induced. In general, it appears as a singular benign lesion, however, there are rare cases that are malignant multicentric forms. The most frequent orofacial localization is the tongue.  The aim of this report was to describe a case of GCT occurring on  the soft palate. Patient presented a discrete and asymptomatic nodule for approximately eight months. Definitive diagnosis of granular cell tumor was established by histological and immunohistochemical analyses. The case illustrates the occurrence of granular cell tumor in an unusual region and emphasizes the importance of including this entity in differential diagnosis of soft tissue tumors in otherwise locations besides the tongue. 

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References

Abrikossoff AL. Über Myome ausgehend von der quergestreiften willkürlichen Muskulatur, Virchows Arch A Pathol Anat Histopathol 1926;260:215–233.

Collins BM, Jones AC: Multiple granuloma cell tumors of oral cavity:report of a case and review of the literature. J Oral Maxillofac Surg 1995,53:707-711.

Fisher ER, Wechsler H. Granular cell myoblastoma-a misnomer: electron microscopic and histochemical evidence concerning its Schwann cell derivation and nature (granular cell schwannoma). Cancer. 1962;15:936–954.

Billeret Lebranchu V. Granular cell tumor.Epidemiology of 263 cases. Arch AnatCytolPathol. 1999;47:26-30.

Gardner ES, Goldberg LH. Granular cell tumor treated with Mohs mi¬crographic surgery: report of a case and review of the literature. Dermatol Surg 2001;27:772-4.

Vered M, Carpenter WM, Buchner A. Granular cell tumor of the oral cavity: Updated immunohistochemical profile. J Oral Pathol Med.2009;38:150–9.

Becelli R, Perugini M, Gasparini G, Cassoni A, Fabiani F. Abrikossoff’s tumor. J Craniofac Surg. 2001 Jan;12(1):78-81.

Bhattacharyya I, Summerlin DJ, Cohen DM, Ellis GL, Bavitz JB, Gillham LL. Granular cell leiomyoma of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:353-9.

Rejas RA, Campos MS, Cortes AR, Pinto DD, de Sousa SC. The neural histogenetic origin of thegranular cell tumor: an immunohistochemical evidence.Med Oral Patol Oral Cir Bucal. 2011 Jan 1;16(1):e6-10.

Caldeira PC, Ribeiro DC, de Almeida OP, Mesquita RA, do Carmo MA. Tumor of the hard palate.Oral Surg Oral MedOral PatholOral Radiol. 2012 Jun;113(6):722-7. doi: 10.1016/j.oooo.2011.09.017.

Neville B, Damm DD, Allen CM, Bouquot JE. Soft tissue tumors. In: Oral and Maxillofacial Pathology. 2nd ed. Philadelphia: W. B. Saunders; 2002. p. 465-66.

Eguia A, Uribarri A, Escoda CG,Crovetto MA, Conde RM, Aguirre JM. Granular cell tumor: report of 8 intraoral cases. Med Oral Patol Oral Cir Bucal 2006;11:E425-8.

Lerman M, Freedman PD. Nonneural granular cell tumor of the oral cavity: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:382-4.

Senoo H, Iida S, Kishino M, Namba N, Aikawa T, Kogo M. Solitary congenital granular cell lesion of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:e45-8.

Fanburg-Smith JC, Miettinen M, Folpe AL, Weiss SW, Childers EL. Lingual alveolar soft part sarcoma; 14 cases: novel clinical and morphological observations. Histopathology. 2004;45:526-37.

Do Nascimento Souza KC, Faria PR, Costa IM, Duriguetto AF Jr, Loyola AM. Oral alveolar soft-part sarcoma: review of literature and case report with immunohistochemistry study for prognostic markers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:64-70.

Boncoeur-Martel MP, Loevner LA, Yousem DM, Elder DE.Granular cell myoblastoma of the cervical esophagus: MR findings.AJNR Am J Neuroradiol 1996;17:1794–1797

Nishida M, Inoue M, Yanai A, Matsumoto T. Malignant granular cell tu¬mor in maseter muscle: case report. J Oral Maxillofac Surg 2000;58:345-8.

Peterson, LJ. Granular-cell tumor: Review of the literature and report of a case. Oral Surg Oral Med Oral Pathol. 1974 May;37(5):728-35.

Miller AS, Leifer C, Chen SY, Harwick RD. Oral granular-cell tumors. Report of twenty-five cases with electron microscopy. Oral Surg Oral Med Oral Pathol. 1977 Aug;44(2):227-37.

Worsaae N, Schwartz O, Pindborg JJ. Follow-up study of 14 oral granular cell tumors. Int J Oral Surg. 1979 Apr;8(2):133-9.

Stewart CM, Watson RE, Eversole LR, Fischlschweiger W, Leider AS. Oral granular cell tumors: a clinicopathologic and immunocytochemical study. Oral Surg Oral Med Oral Pathol. 1988 Apr;65(4):427-35.

Desai DP, Maddalozzo J, Holinger LD. Granular cell tumor of the trachea. Otolaryngol Head Neck Surg 1999;120:595–598.

Choukas NC, Seklecki EW, Toto PD, Short MH. Granular cell myoblastoma of the soft palate.Report of a case.Int J Oral Surg. 1978 Apr;7(2):123-5.

Lamey PJ, Rennie JS, James J. Multiple granular cell tumors of the palate.Int J Oral Maxillofac Surg. 1987 Apr;16(2):236-8.

Bernat Gili A, Ayerbe TV, Baena AA, Rivares EJ, Oncins TR. Abrikosoff's tumor of the soft palate: A case report. AnOtorrinolaringol Ibero Am 1999;26:47-53.

Giuliani M, Lajolo C, Pagnoni M, Boari A, Zannonni GF. Granular cell tumor of the tongue (Abrikossoff´s tumor).A case report and review of the literature. Minerva Stomatol 2004;53:465-9.

Budiño-Carbonero S, Navarro-Vergara P, Rodríguez-Ruiz JA, Modelo-Sánchez A, Torres-Garzón L, Rendón-Infante JI, et al. Granular cell tumors: Review of the parameters determining possible malignancy. Med Oral. 2003;8:294-8.

Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: Diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1998;22:779–794.

Freitas VS, dos Santos JN, Oliveira MC, Santos PP, Freitas Rde A, de Souza LB. Intraoral granular cell tumors: clinicopathologic and immunohistochemical study. Quintessence Int. 2012. Feb;43(2):135-42.

Poveda R. Granular cell tumour.Med Oral 2004;9:362.

He JF, Lin Y, Liu JH, Li ZY. Solitary S-100-Positive Congenital Granular Cell Tumor of the Tongue: A Case Report and Literature Review.Ann Plast Surg. 2012 Dec 13. [Epub ahead of print].

Sena Costa NC, Bertini F, Carvalho YR, Almeida JD, Rodrigues Cavalcante AS.Granular cell tumor presenting as a tongue nodule: two case reports. J Med Case Rep. 2012 Feb 10;6:56. doi: 10.1186/1752-1947-6-56.

Goodstein ML, Eiselle DW, Hyams JV, Kashima HK. Multiple synchro¬nous granular cell tumors of the upper aerodigestive tract.Otolaryngol Head Neck Surg 1990;103:664-8.

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Published

2015-12-18

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Section

Case report or technical report

How to Cite

Jacomacci, W. P. (2015). Granular Cell Tumor on the soft palate: a very rare location. Clinical and Laboratorial Research in Dentistry, 21(1), 58-64. https://doi.org/10.11606/issn.2357-8041.clrd.2015.96108