Hpv and oropharyngeal cancer
DOI:
https://doi.org/10.11606/issn.2357-8041.clrd.2021.184527Keywords:
Oropharyngeal neoplasms, HPV, Medical oncologyAbstract
Objectives: To review the international and national scientific production on Human Papillomavirus (HPV) and head and neck cancer, focusing on oropharyngeal tumors. Materials and Method: This is a systematic literature review conducted in the PubMed database for electronic resources published between 1999 and 2019. Results: The results indicate that HPV is a factor for the formation of oropharyngeal squamous cells carcinoma (OPSCC), being HPV-16 the most common type of HPV related to OPSCC. Conclusions: Before the elevated rates of morbidity and late diagnosis of head and neck cancer, early diagnosis plays a key role in patients affected with this condition.
Downloads
References
Lewis A, Kang R, Levine A, Maghami E. The New Face of Head and Neck Cancer: The HPV Epidemic. Oncology (Williston Park). 2015;29(9):616-26.
Instituto Nacional do Câncer (BR). Homepage [Internet]. Rio de Janeiro: INCA; 2009 [citado em 15 maio 2018]. Disponível em: www.inca.gov.br
Albano PM, Holzinger D, Salvador C, Orosa J 3rd, Racelis S, Leaño M, Sanches D Jr, et al. Low prevalence of human papilloma virus in head and neck squamous cell carcinoma in the north west region of the Philippines. PLoSOne. 2017;12(2):e0172240. doi: https://doi.org/10.1371/journal.pone.0172240.
Mehanna H, Paleri V, West C, Nutting C. Head and neck cancer – Part 1: Epidemiology, presentation, and prevention. BMJ. 2010;341:c4684. doi: https://doi.org/10.1136/bmj.c4684.
Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009;45(4-5):309-16. doi: https://doi.org/10.1016/j.oraloncology.2008.06.002.
Siegel R, Naishadham D, Jemal A. Cancer Statistics, 2012. CA Cancer J Clin. 2012;62(1):10-29. doi: https://doi.org/10.3322/caac.20138t.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90. doi: https://doi.org/10.3322/caac.20107.
Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol. 2008;26(4):612-9. doi: https://doi.org/10.1200/JCO.2007.14.1713.
Viens LJ, Henley SJ, Watson M, Markowitz LE, Thomas CC, Thompson TD, et al. Human papilomavirus: associated cancers: United States, 2008-2012. MMWR Morb Mortal Wkly Rep. 2016;65(26):661-6. doi: https://doi.org/10.15585/mmwr.mm6526a1.
Wirth L, Burtness B, Nathan CA, Grégoire V, Richmon J. Point/Counterpoint: Do We De-escalate Treatment of HPV-Associated Oropharynx Cancer Now? And How? Am Soc Clin Oncol Educ Book. 2019;39:364-72. doi: https://doi.org/10.1200/EDBK_238315.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Biological agents: Volume 100B: A review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt B):1-441.
Bedell SL, Goldstein LS, Goldstein AR, Goldstein AT. Cervical Cancer Screening: past, present, and future. Sex Med Rev. 2020;8(1):28-37 doi: https://doi.org/10.1016/j.sxmr.2019.09.005.
Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12-9. doi: https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9896(199909)189:1%3C12::AID-PATH431%3E3.0.CO;2-F
Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer. 2017;141(4):664-70. doi: https://doi.org/10.1002/ijc.30716.
Berman TA, Schiller JT. Human papillomavirus in cervical cancer and oropharyngeal cancer: One cause, two diseases. Cancer. 2017;123(12):2219-29. doi: https://doi.org/10.1002/cncr.30588.
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Matthers C, Rebelo M, et al. GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012 v1.0. Lyon: IARC; 2013.
D’Souza G, Cullen K, Bowie J, Thorpe R, Fakhry C. Differences in oral sexual behaviors by gender, age, and race explain observed differences in prevalence of oral human papillomavirus infection. PLoSOne. 2014;9(1):19-21. doi: https://doi.org/10.1371/journal.pone.0086023.
Gao G, Smith DI. Human Papillomavirus and the Development of Different Cancers. Cytogenet Genome Res. 2016; 150(3-4):185-93. doi: https://doi.org/10.1159/000458166.
Taberna M, Inglehart RC, Pickard RK, Fakhry C, Agrawal A, Kats ML, et al. Significant changes in sexual behavior after a diagnosis of human papillomavirus-positive and human papillomavirus-negative oral cancer. Cancer. 2017;123(7):1156-65. doi: https://doi.org/10.1002/cncr.30564.
Combes JD, Chen AA, Franceschi S. Prevalence of human papillomavirus in cancer of the oropharynx by gender. Cancer Epidemiol Biomarkers Prev. 2014;23(12):2954-8. doi: https://doi.org/10.1158/1055-9965.EPI-14-0580.
Li H, Torabi SJ, Yarbrough WG, Mehra S, Osborn HA, Judson B. Association of Human Papillomavirus Status at Head and Neck Carcinoma Subsites With Overall Survival. JAMA Otolaryngol Head Neck Surg. 2018;144(6):519-525. doi: https://doi.org/10.1001/jamaoto.2018.0395.
Saunders CL, Meads C, Abel GA, Lyratzopoulos G. Associations Between Sexual Orientation and Overall and Site-Specific Diagnosis of Cancer: Evidence From Two National Patient Surveys in England. J Clin Oncol. 2017;35(32):3654-61. doi: https://doi.org/10.1200/JCO.2017.72.5465.
Gillison ML, Castellsagué X, Chaturvedi A, Goodman MT, Snijders P, Tommasino M, et al. Eurogin Roadmap: comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix. Int J Cancer. 2014;134(3):497-507. doi: https://doi.org/10.1002/ijc.28201.
Organización Panamericana de la Salud. Classificación estadística internacional de enfermedades y problemas relacionados con la salud: décima revisión. Washington, DC: OPS; 1995.
Agalliu I, Gapstur S, Chen Z, Wang T, Anderson RL, Teras L, et al. Associations of Oral α-, β-, and γ-Human papillomavirus types with risk of incident head and neck cancer. JAMA Oncol. 2016;2(5):599-606. doi: https://doi.org/10.1001/jamaoncol.2015.5504.
Benson E, Li R, Eisele D, Fakhry C. The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas. Oral Oncol. 2014;50(6):565-74. doi: https://doi.org/10.1016/j.oraloncology.2013.09.008.
Fakhry C, Westra WH, Wang SJ, van Zante A, Zhang Y, Rettig E, et al. The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer. Cancer. 2017;123(9):1566-75. doi: https://doi.org/10.1002/cncr.30353.
Reuschenbach M, Wagner S, Würdemann N, Sharma SJ, Prigge ES, Sauer M, et al. Human papillomavirus and squamous cell cancer of the head and neck region: Prognostic, therapeutic and prophylactic implications. HNO. 2016;64(7):450-9. doi: https://doi.org/10.1007/s00106-016-0123-0.
Sturgis EM, Cinciripini PM. Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers? Cancer. 2007;110(7):1429-35. doi: https://doi.org/10.1002/cncr.22963.
Marur S, D’Souza G, Westra WH, Forastiere AA. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 2010;11(8):781-9. doi: https://doi.org/10.1016/S1470-2045(10)70017-6.
Hammarstedt L, Lindquist D, Dahlstrand H, Romanitan M, Dahlgren LO, Joneberg J, et al. Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer. Int J Cancer. 2006;119(11):2620-3. doi: https://doi.org/10.1002/ijc.22177.
Rietbergen MM, van Bokhoven AA, Lissenberg‐Witte BI, Heideman DAM, Leemans CR, Brakenhoff RH, et al. Epidemiologic associations of HPV‐positive oropharyngeal cancer and (pre)cancerous cervical lesions. I Jornal Cancer. 2018;143(2):283-8. doi: https://doi.org/10.1002/ijc.31315.
Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24-35. doi: https://doi.org/10.1056/NEJMoa0912217.
Ndiaye C, Mena M, Alemany L, Arbyn M, Castellsagué X, Laporte L, et al. HPV DNA, E6/E7 mRNA, and p16(INK4a) detection in head and neck cancers: a systematic review and meta-analysis. Lancet Oncol. 2014;15(12):1319-31. doi: https://doi.org/10.1016/S1470-2045(14)70471-1.
Klussmann JP, Preuss SF, Speel EJ. Human papillomavirus and cancer of the oropharynx. Molecular interaction and clinical implications. HNO. 2009;57(2):113-22. doi: https://doi.org/10.1007/s00106-008-1867-y.
Figueiredo AM. Prevalências e características clínico-epidemiológicas do câncer bucal e de cabeça e pescoço no Hospital Estadual de Bauru/SP [tese]. São Paulo: Universidade de São Paulo; 2013.
Petito G, Carneiro MAS, Santos SHR, Silva AMTC, Alencar RC, Gontijo AP, et al. Human papillomavirus in oral cavity and oropharynx carcinomas in the central region of Brazil. Braz J Otorhinolaryngol. 2017;83(1):38-44. doi: https://doi.org/10.1016/j.bjorl.2016.01.004.
Caley A, Evans M, Powell N, Paleri V, Tomkinson A, Urbano TG, et al. Multicentric human papillomavirus-associated head and neck squamous cell carcinoma. Head Neck. 2015;37(2):202-8. doi: https://doi.org/10.1002/hed.23584.
Cardoso MFA, Novikoff S, Tresso A, Segreto RA, Cervantes O. Prevenção e controle das sequelas bucais em pacientes irradiados por tumores de cabeça e pescoço. Radiol Bras. 2005;38(2):107-15. doi: https://doi.org/10.1590/S0100-39842005000200006.
Graeff A, de Leeuw JR, Ros WJ, Hordijk GJ, Blijham GH, Winnubst JA. Pretreatment factors predicting quality of life after treatment for head and neck cancer. Head Neck. 2000;22(4):398-407. doi: https://doi.org/10.1002/1097-0347(200007)22:4<398::aid-hed14>3.0.co;2-v.
Chinn SB, Myers JN. Oral cavity carcinoma: current management, controversies, and future directions. J Clin Oncol. 2015;33(29):3269-76. doi: https://doi.org/10.1200/JCO.2015.61.2929.
Burd EM, Dean CL. Human papillomavirus. Microbiol Spectr. 2016;4(4). doi: 10.1128/microbiolspec.DMIH2-0001-2015.
Yeh DH, Tam S, Fung K, MacNeil SD, Yoo J, Winquist E, et al. Transoral robotic surgery vs. radiotherapy for management of oropharyngeal squamous cell carcinoma: a systematic review of the literature. Eur J Surg Oncol. 2015;41(12):1603-14. doi: https://doi.org/10.1016/j.ejso.2015.09.007.
Heijnen BJ, Speyer R, Kertscher B, Cordier R, Koetsenruijter KWJ, Swan K, et al. Dysphagia, Speech, Voice, and Trismus following Radiotherapy and/or Chemotherapy in Patients with Head and Neck Carcinoma: Review of the Literature. Biomed Res Int. 2016;2016:6086894. doi: https://doi.org/10.1155/2016/6086894.
King SN, Dunlap NE, Tennant PA, Pitts T. Pathophysiology of Radiation-Induced Dysphagia in Head and Neck Cancer. Dysphagia. 2016;31(3):339-51. doi: https://doi.org/10.1007/s00455-016-9710-1.
Connor NP, Cohen SB, Kammer RE, Sullivan PA, Brewer KA, Hong TS, et al. Impact of conventional radiotherapy on health-related quality of life and critical functions of the head and neck. Int J Radiat Oncol Biol Phys. 2006;65(4):1051-62. doi: https://doi.org/10.1016/j.ijrobp.2006.01.054.
Knox JJ, Puodziunas AL, Feld R. Chemotherary-induced oral mucositis: Prevention and management. Drugs Aging. 2000;17(4):257-67. doi: https://doi.org/10.2165/00002512-200017040-00002.
Stoeckli SJ, Guidicelli M, Schneider A, Huber A, Schmid S. Quality of life after treatment for early laryngeal carcinoma. Eur Arch Otorhinolaryngol. 2001;258(2):96-9. doi: https://doi.org/10.1007/s004050000307.
Joseph AW, Ogawa T, Bishop JA, Lyford-Pike S, Chang X, Phelps TH, et al. Molecular etiology of second primary tumors in contralateral tonsils of human papillomavirus-associated index tonsillar carcinomas. Oral Oncol. 2013;49(3):244-8. doi: https://doi.org/10.1016/j.oraloncology.2012.09.009.
Naghavi AO, Echevarria MI, Strom TJ, Abuodeh YA, Ahmed KA, Venkat PS, et al. Treatment delays, race, and outcomes in head and neck cancer. Cancer Epidemiol. 2016;45:18-25. doi: https://doi.org/10.1016/j.canep.2016.09.005
Okami K. Clinical features and treatment strategy for HPV-related oropharyngeal cancer. Int J Clin Oncol. 2016;21(5):827-35. doi: https://doi.org/10.1007/s10147-016-1009-6.
American Cancer Society. Cancer Facts & Figures 2016. Atlanta: American Cancer Society; 2016.
Downloads
Published
Issue
Section
License
Copyright (c) 2021 Juliana Milioli Voltolini, Felipe Daniel Búrigo dos Santos
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors are requested to send, together with the letter to the Editors, a term of responsibility. Thus, the works submitted for appreciation for publication must be accompanied by a document containing the signature of each of the authors, the model of which is presented as follows:
I/We, _________________________, author(s) of the work entitled_______________, now submitted for the appreciation of Clinical and Laboratorial Research in Dentistry, agree that the authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
Date: ____/____/____Signature(s): _______________
