Extracellular vesicles: what we know so far
DOI:
https://doi.org/10.11606/issn.2357-8041.clrd.2021.180055Keywords:
Extracellular vesicles, Exosomes, Cell communicationAbstract
This study aimed to address and clarify some concepts about the extracellular vesicles (EVs) and their nomenclature based on a literature review. A literature review was performed using the Scielo, Lilacs and Medline/PubMed databases. Scientific research and literature review articles about VEs published from 2010 to 2021 in English language were verified. Thenceforth, 33 articles were selected to compose this study. EVs are nano to micrometric- sized particles, delimited by cell membrane and released from living organisms, which play an important role on cell communication. The main types of EVs are exosomes, microvesicles and apoptotic bodies, which present overlapping features that may lead to confusion in their characterization. Studies have tried to isolate the different types of VEs, but there are neither effective methods of purification nor specific markers yet. Based on the current literature, the present study reinforces the importance of detailed description about methods of isolation and characterization in studies which use VEs and suggests maintaining the use of the term “EVs” instead of more specific terms, thus attempting to reduce possible biases and facilitate comparison between studies.
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