Comparison of pre- and post-levothyroxine high-sensitivity c-reactive protein and fetuin-a levels in subclinical hypothyroidism

Authors

  • Oktay Bilgir Izmir Bozyaka Education and Research Hospital; Department of Internal Medicine
  • Ferda Bilgir Katip Celebi University Medical School; Department of Allergy and Immunology
  • Mehmet Calan Izmir Bozyaka Education and Research Hospital; Department of Internal Medicine
  • Ozlem Gursoy Calan Dokuz Eylul University Medical School; Department of Biochemistry
  • Arif Yuksel Izmir Bozyaka Education and Research Hospital; Department of Internal Medicine

DOI:

https://doi.org/10.6061/clinics/2015(02)05

Abstract

OBJECTIVE: The objective of this trial was to determine the levels of inflammatory markers, high-sensitivity C-reactive protein and fetuin-A pre- and post-levothyroxine treatment in cases of subclinical hypothyroidism. MATERIALS AND METHODS: A total of 32 patients with a diagnosis of subclinical hypothyroidism and a control group of 30 healthy individuals were tested for high-sensitivity C-reactive protein and fetuin-A, followed by the administration of 50 µg of levothyroxine in the patient group for 3 months. During the post-treatment stage, high-sensitivity C-reactive protein and fetuin-A levels in the patient group were re-assessed and compared with pre-treatment values. RESULTS: Pre-treatment levels of both high-sensitivity C-reactive protein and fetuin-A were observed to be higher in the patient group than in the control group. The decrease in high-sensitivity C-reactive protein levels during the post-treatment stage was not statistically significant. However, the decrease observed in post-treatment fetuin-A levels was found to be statistically significant. CONCLUSION: The decrease in fetuin-A levels in subclinical hypothyroidism cases indicates that levothyroxine treatment exerts anti-inflammatory and anti-apoptotic effects. Although the decrease in high-sensitivity C-reactive protein levels was statistically non-significant, it is predicted to reach significance with sustained treatment.

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Published

2015-02-01

Issue

Section

Clinical Sciences

How to Cite

Comparison of pre- and post-levothyroxine high-sensitivity c-reactive protein and fetuin-a levels in subclinical hypothyroidism . (2015). Clinics, 70(2), 97-101. https://doi.org/10.6061/clinics/2015(02)05