Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis

Authors

  • Jie You Department of Public Health; Luohu Center for Disease Control and Prevention
  • YaJun Yue Department of Chemical Laboratory; Luohu Center for Disease Control and Prevention
  • Feng Xing Department of Public Health; Leizhou Center for Disease Control and Prevention
  • Wei Xia Department of Public Health; Luohu Center for Disease Control and Prevention
  • ShaoYang Lai Department of Chemical Laboratory; Luohu Center for Disease Control and Prevention
  • FengLei Zhang Department of Public Health; Luohu Center for Disease Control and Prevention

DOI:

https://doi.org/10.6061/clinics/2015(01)05

Abstract

OBJECTIVES: To investigate an unusual outbreak of tetrodotoxin poisoning in Leizhou, southeast China, a case series analysis was conducted to identify the source of illness. METHODS: A total of 22 individuals experienced symptoms of poisoning, including tongue numbness, dizziness, nausea and limb numbness and weakness. Two toxic species, Amoya caninus and Yongeichthys nebulosus, were morphologically identified from the batches of gobies consumed by the patients. Tetrodotoxin levels in the blood and Goby fish samples were detected using liquid chromatography-tandem mass spectrometry. RESULTS: The tetrodotoxin levels in the remaining cooked Goby fish were determined to be 2090.12 µg/kg. For Amoya caninus, the toxicity levels were 1858.29 µg/kg in the muscle and 1997.19 µg/kg in the viscera and for Yongeichthys nebulosus, they were 2783.00 µg/kg in the muscle and 2966.21 µg/kg in the viscera. CONCLUSION: This outbreak demonstrates an underestimation of the risk of Goby fish poisoning. Furthermore, the relationships among the toxic species, climates and marine algae present should be clarified in the future.

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Published

2015-01-01

Issue

Section

Clinical Sciences

How to Cite

You, J., Yue, Y., Xing, F., Xia, W., Lai, S., & Zhang, F. (2015). Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis . Clinics, 70(1), 24-29. https://doi.org/10.6061/clinics/2015(01)05