Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma

Authors

  • Ricardo Jureidini Universidade de São Paulo; Faculdade de Medicina da Universidade de São Paulo
  • José Eduardo Monteiro da Cunha Universidade de São Paulo; Faculdade de Medicina da Universidade de São Paulo
  • Flavio Takeda Universidade de São Paulo; Faculdade de Medicina da Universidade de São Paulo
  • Guilherme Naccache Namur Universidade de São Paulo; Faculdade de Medicina da Universidade de São Paulo
  • Thiago Costa Ribeiro Universidade de São Paulo; Faculdade de Medicina da Universidade de São Paulo
  • Rosely Patzina Departamento de Patologia
  • Estela RR Figueira Universidade de São Paulo; Faculdade de Medicina da Universidade de São Paulo
  • Ulysses Ribeiro Jr Universidade de São Paulo; Faculdade de Medicina da Universidade de São Paulo
  • Telesforo Bacchella Universidade de São Paulo; Faculdade de Medicina da Universidade de São Paulo
  • Ivan Cecconello Universidade de São Paulo; Faculdade de Medicina da Universidade de São Paulo

DOI:

https://doi.org/10.6061/clinics/2016(06)05

Abstract

OBJECTIVE: To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer. METHODS: Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope. RESULTS: The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure. CONCLUSIONS: Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma.

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Published

2016-06-01

Issue

Section

Clinical Sciences

How to Cite

Jureidini, R., da Cunha, J. E. M., Takeda, F., Namur, G. N., Ribeiro, T. C., Patzina, R., Figueira, E. R., Ribeiro Jr, U., Bacchella, T., & Cecconello, I. (2016). Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma . Clinics, 71(6), 315-319. https://doi.org/10.6061/clinics/2016(06)05