Antibacterial evaluation of Styrax pohlii and isolated compounds

Authors

  • Camila Spereta Bertanha University of Franca; Center for Research in Exact and Technological Sciences
  • Susane Hellen Utrera University of Franca; Center for Research in Exact and Technological Sciences
  • Valéria Maria Melleiro Gimenez Claretiano University Center
  • Milton Groppo University of São Paulo; Faculty of Philosophy, Sciences and Literature of Ribeirão Preto
  • Márcio Luis Andrade e Silva University of Franca; Center for Research in Exact and Technological Sciences
  • Wilson Roberto Cunha University of Franca; Center for Research in Exact and Technological Sciences
  • Carlos Henrique Gomes Martins University of Franca; Center for Research in Exact and Technological Sciences
  • Ana Helena Januário University of Franca; Center for Research in Exact and Technological Sciences
  • Patrícia Mendonça Pauletti University of Franca; Center for Research in Exact and Technological Sciences

DOI:

https://doi.org/10.1590/S1984-82502013000400004

Abstract

The antibacterial activity of the compounds egonol (1) and homoegonol (2), of the crude ethanolic extract of Styrax pohlii (Styracaceae) aerial parts (EE), and of its n-hexane (HF), EtOAc (EF), n-BuOH (BF), and hydromethanolic (HMF) fractions was evaluated against the following microorganisms: Streptococcus pneumoniae (ATCC 6305), S. pyogenes (ATCC 19615), Haemophilus influenzae (ATCC 10211), Pseudomonas aeruginosa (ATCC 27853), and Klebsiella pneumoniae (ATCC 10031). The broth microdilution method was used for determination of the minimum inhibitory concentration (MIC) during preliminary evaluation of antibacterial activity. The EE yielded MIC values of 400 µg/mL for S. pneumoniae and P. aeruginosa and 300 µg/mL for H. influenzae. The HF and EF fractions exhibited enhanced antibacterial activity, with MIC values of 200 µg/mL against S. pneumoniae, but only EF displayed activity against H. influenzae (MIC 200 µg/mL). The best MIC value with compounds 1 and 2 (400 µg/mL) was obtained for (1) against S. pneumoniae and P. aeruginosa. Therefore, 1 exhibited weak antibacterial activity against these standard strains.

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Published

2013-12-01

Issue

Section

Articles

How to Cite

Antibacterial evaluation of Styrax pohlii and isolated compounds . (2013). Brazilian Journal of Pharmaceutical Sciences, 49(4), 653-658. https://doi.org/10.1590/S1984-82502013000400004