Production and characterization of alginate-starch-chitosan microparticles containing stigmasterol through the external ionic gelation technique

Authors

  • Gislene Mari Fujiwara Federal University of Paraná; Department of Pharmacy
  • Ranieri Campos Federal University of Paraná; Department of Pharmacy
  • Camila Klocker Costa Federal University of Paraná; Department of Pharmacy
  • Josiane de Fátima Gaspari Dias Federal University of Paraná; Department of Pharmacy
  • Obdulio Gomes Miguel Federal University of Paraná; Department of Pharmacy
  • Marilis Dallarmi Miguel Federal University of Paraná; Department of Pharmacy
  • Francisco de Assis Marques Federal University of Paraná; Department of Chemistry
  • Sandra Maria Warumby Zanin Federal University of Paraná; Department of Pharmacy

DOI:

https://doi.org/10.1590/S1984-82502013000300015

Keywords:

Stigmasterol^i1^smicroencapsulat, Microencapsulation, Sodium alginate^i1^sdrugs coat, Chitosan^i1^sdrugs coat, Starch^i1^sdrugs coat, Natural polymers^i1^sdrugs coat

Abstract

Stigmasterol - a plant sterol with several pharmacological activities - is susceptible to oxidation when exposed to air, a process enhanced by heat and humidity. In this context, microencapsulation is a way of preventing oxidation, allowing stigmasterol to be incorporated into various pharmaceutical forms while increasing its absorption. Microparticles were obtained using a blend of polymers of sodium alginate, starch and chitosan as the coating material through a one-stage process using the external gelation technique. Resultant microparticles were spherical, averaging 1.4 mm in size. Encapsulation efficiency was 90.42% and method yield 94.87%. The amount of stigmasterol in the oil recovered from microparticles was 9.97 mg/g. This technique proved feasible for the microencapsulation of stigmasterol.

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Published

2013-09-01

Issue

Vol. 49 No. 3 (2013)

Section

Articles

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Production and characterization of alginate-starch-chitosan microparticles containing stigmasterol through the external ionic gelation technique . (2013). Brazilian Journal of Pharmaceutical Sciences, 49(3), 537-547. https://doi.org/10.1590/S1984-82502013000300015