Physiologically Based Pharmacokinetic and Physiologically Based Biopharmaceutic models research in Latin America: A regional level bibliometric analysis, 2011-2023

Juliana Cordeiro  Cardoso; José Eduardo Severino  Martins; Aline Ferreira  Pinto; Eliana Maria Barbosa  Souto; Marx  Ribeiro; Patricia  Severino

doi:10.1590/

Authors

Juliana Cordeiro Cardoso Tiradentes University, Aracaju, Brazil; Instituto de Tecnologia e Pesquisa, Aracaju, Brazil https://orcid.org/0000-0002-0357-4144
José Eduardo Severino Martins Laboratory of Research in Biotechnology and Hemoderivatives, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil https://orcid.org/0000-0002-3855-5701
Aline Ferreira Pinto Laboratory of Research in Biotechnology and Hemoderivatives, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Brazil https://orcid.org/0000-0003-2123-2284
Eliana Maria Barbosa Souto UCD School of Chemical and Bioprocess Engineering, University College Dublin, Dublin, Ireland https://orcid.org/0000-0002-9737-6017
Marx Ribeiro GRANTE, Mechanical Engineering Department, Federal University of Santa Catarina, Florianópolis, Brazil; Clinic for Trauma and Reconstructive Surgery, University Hospital Halle, Halle(Saale), Germany https://orcid.org/0000-0003-3341-3605
Patricia Severino Tiradentes University, Aracaju, Brazil https://orcid.org/0000-0001-6527-6612

DOI:

https://doi.org/10.1590/

Keywords:

PBPK, PBBM, Latin America Scientometric analysis, International collaboration

Abstract

The landscape of scientific research in Latin America (LA), particularly in the realms of the Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutic models (PBPM), is a mosaic of varied contributions, collaborations, and specializations. This study examines research production in the region using data from the Scopus and PubMed databases collected between 2011 and 2023. Brazil stands out as a prominent country in terms of the quantity of publications. When considering thematic specialization, Colombia cones first as the country with the greatest Relative Specialization Index (RSI), followed by Brazil, Cuba, Uruguay, Mexico, and Argentina. Regarding internationalization, Brazil and Mexico are currently exerting significant influence, particularly through their increasing cooperation with the United States and Europe. Interestingly, there is a lack of cooperation inside Latin America at the regional level. Regarding the contribution of Latin-American institutions, the State University of Maringá leads in number of publications, followed by the University of São Paulo and the Federal University of São Paulo. In this work, we analyzed the strengths and weaknesses of LA’s scientific contributions, offering a roadmap for future collaborative and specialized efforts in the field of PBPK and PBBM.

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References

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Physiologically Based Pharmacokinetic and Physiologically Based Biopharmaceutic models research in Latin America

A regional level bibliometric analysis, 2011-2023

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