Unlocking the potential of collagen
A comprehensive review on its dermocosmetic benefits and applications
DOI:
https://doi.org/10.1590/Keywords:
Ageing, Stress, Structural units, Fibrils, PhotodamageAbstract
Collagen, the predominant protein in various organisms, is pivotal for tissue structure and mechanical properties. It has been extensively studied for its cosmetic, surgical, and anti-ageing applications, reflecting a growing interest in collagen-based cosmetics in Romania and prompting further research in this area. The study aimed to assess collagen’s efficacy and safety in dermocosmetology, comparing collagen peptides’ effectiveness in oral and topical applications. An analysis of the published studies on the subject was carried out, comparing the effectiveness of using collagen in different ways to improve skin conditions. The investigation included a literature review on collagen’s role in enhancing skin properties, covering its discovery, structure, chemical composition, systemic and topical applications, diverse sources, and skin penetration mechanisms. Hydrolysed collagen and its antioxidant properties are considered. The methods of investigating and monitoring the safety of cosmetic preparations are described. It has been concluded that topical collagen, similarly to nutraceutical supplements with collagen peptides, can slow down and reduce the signs of skin ageing and can increase skin elasticity, density, and moisture in equal measure. Studies have confirmed the harmlessness of collagen beyond doubt, but further investigation is necessary to determine the effectiveness of using different types of collagen.
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References
Adamiak K, Sionkowska A. The influence of UV irradiation on fish skin collagen films in the presence of xanthohumol and propanediol. Biomol Spectosc. 2022; 258: 121652.
Aguirre-Cruz G, León-López A, Cruz-Gómez V, Jiménez-Alvarado R, Aguirre-Álvarez G. Collagen hydrolysates for skin protection: Oral administration and topical formulation. Antioxidants. 2020; 9(2): 181.
Alves T, Morsink M, Batain F, Chaud MV, Almeida T, Fernandes DA, et al. Applications of natural, semi-synthetic, and synthetic polymers in cosmetic formulations. Cosmetics. 2020; 7(4): 75.
Bhagwat PK, Dandge PB. Collagen and collagenolytic proteases: A review. Biocatal Agric Biotechnol. 2018; 15: 43-55.
Bianchi FM, Angelinetta C, Rizzi G, Pratico A, Villa R. Evaluation of the efficacy of a hydrolyzed collagen supplement for improving skin moisturization, smoothness, and wrinkles. J Clin Aesthetic Dermatol. 2022; 15(3): 48-52.
Bolke L, Schlippe G, Gerß G, Vossа W. A collagen supplement improves skin hydration, elasticity, roughness, and density: Results of a randomized, placebo-controlled, blind study. Nutrients. 2019; 11(10): 2494.
Bortolozo F, Menezes HS, Alves DD, Mafaldo RC. Collagen biostimulator with polymethylmethacrylate. Indian J Appl Res. 2021; 11(4): 2249.
Campos PMBG, Melo MO, Cesar FCS. Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density. J Cosmet Dermatol. 2019; 18(6): 1693-1699.
Cao C, Xiao Z, Wu Y, Ge C. Diet and skin aging - from the perspective of food nutrition. Nutrients. 2020; 12(3): 870.
Chen Y, Lyga J. Brain-skin connection: Stress, inflammation and skin aging. Inflamm Allergy Drug Targets. 2014; 13(3): 177-190.
Clark GL, Parker EA, Schaad JA, Warren WJ. New measurements of previously unknown large interplanar spacings in natural materials. J Am Chem Soc. 1935; 57(8): 1509.
Datta D, Madke B, Das A. Skin as an endocrine organ: A narrative review. Indian J Dermatol Venereol Leprol. 2021; 88(5): 590-597.
Dsouza L, Ghate VM, Lewis SA. Derma rollers in therapy: The transition from cosmetics to transdermal drug delivery. Biomed Microdevices. 2020; 22(4): 77.
Evans M, Lewis E, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2020; 20(3): 825-834.
Furtado M, Chen L, Chen Z, Chen A, Cui W. Development of fish collagen in tissue regeneration and drug delivery. Eng Regener. 2022; 3(3): 217-231.
García-Sifuentes CO, Zamorano-Apodaca JC, Martínez-Porchas M, Scheuren-Acevedo SM, Mazorra-Manzano MA. Isolation and properties of collagen extracted from mixed by-products obtained from different fish species. Biotecnia. 2021; 23(3): 109-116.
Gaspar-Pintiescu A, Stefan LM, Anton ED, Berger D, Matei C, Negreanu-Pirjol T, Moldovan L. Physicochemical and biological properties of gelatin extracted from marine snail Rapana venosa. Mar Drugs. 2019; 17(10): 589.
Hevia O. Safety and efficacy of polymethylmethacrylate-collagen gel filler for correction of the pre-jowl sulcus: A 24-month prospective study. Aesthet Surg J Open Forum. 2022; 4: ojac030.
Huang L, Ding S, Chen T, Wu R, Wang X, Jia S. Structural and functional properties of collagen from tilapia scales pretreated by heat-assisted ionic liquids. J Appl Polym Sci. 2021; 139(14): 51903.
Hulmes DJ. Building collagen molecules, fibrils, and suprafibrillar structures. J Struct Biol. 2002; 137: 2-10.
Ivashko M, Burmei S, Yusko L, Chaikovska T, Boyko N. Microbiological diagnostics: From traditional to molecular genetic methods: A literature review. Bull Med Biol Res. 2023; 5(4): 34-41.
Jairoun AA, Shahwan M, Zyoud SH. Heavy metal contamination of dietary supplements products available in the UAE markets and the associated risk. Sci Rep. 2020; 10(1): 18824.
Jeong WY, Kwon M, Cho HE, Kim KS. Recent advances in transdermal drug delivery systems: A review. Biomater Res. 2021; 25(1): 24.
Jin X, Zhang X, Li Y, Xu M, Wu Z, He Y, Gao J, Li B. Long-acting microneedle patch loaded with adipose collagen fragment for preventing the skin photoaging in mice. Biomater Adv. 2022; 135: 212744.
Joseph JH, Shamban A, Eaton A, Lehman A, Cohen S, Spencer J, et al. Polymethylmethacrylate collagen gel-injectable dermal filler for full face atrophic acne scar correction. Dermatol Surg. 2019; 45(12): 1558-1566.
Karami A, Tebyanian H, Soufdoost RS, Motavallian E, Barkhordari A, Nourani MR. Extraction and characterization of collagen with cost-effective method from human placenta for biomedical applications. World J Plast Surg. 2019; 8(3): 352-358.
Katz B, Lehman A, Misev V, Vachon G, Saeed S. A 12-month study to evaluate safety and efficacy of polymethylmethacrylate-collagen gel for correction of midface volume loss using a blunt cannula as measured by 3-D imaging. Dermatol Surg. 2021; 47(3): 365-369.
Kim JH, Kwon T, Hong SW, Seok J, Kim JM, Hong YJ, et al. Comparative evaluation of the biodegradability and wrinkle reduction efficacy of human-derived collagen filler and hyaluronic acid filler. Aesthet Plast Surg. 2019; 43: 1095-1101.
Khudan-Tsilo I, Shevchuk O, Korda M. Cytokines profile in experimental contact allergic dermatitis and use of nanoencapsulated preparations. Intern J of Med and Med Res. 2018; 4(1): 71-77. https://doi.org/10.11603/ijmmr.2413-6077.2018.1.8733
» https://doi.org/10.11603/ijmmr.2413-6077.2018.1.8733
Lee YI, Lee SG, Jung I, Suk J, Lee M, Kim D, Lee JH. Effect of a topical collagen tripeptide on antiaging and inhibition of glycation of the skin: A pilot study. Mol Sci. 2022; 23(3): 1101.
Leighton MP, Rutenberg AD, Kreplak L. D-band strain underestimates fibril strain for twisted collagen fibrils at low strains. J Mech Behav Biomed Mater. 2021; 124: 104854.
León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis D, Aguirre-Álvare G. Hydrolyzed collagen - sources and applications. Molecules. 2019; 24(22): 4031.
Li C, Fu Y, Dai H, Wang Q, Gao R, Zhang R. Recent progress in preventive effect of collagen peptides on photoaging skin and action mechanism. Food Sci Hum Wellness. 2021; 11(2): 218-229.
Li K, Meng F, Li YR, Chen H, Tian Y, Jia Q, et al. Application of nonsurgical modalities in improving facial aging. Int J Dentistry. 2022; 2022: 8332631.
Liu W, Lin H, Zhao P, Xing L, Li J, Wang Z, et al. A regulatory perspective on recombinant collagen-based medical devices. Bioact Mater. 2021; 12: 198-202.
Lo S, Fauzi MB. Current update of collagen nanomaterials-fabrication, characterisation and its applications: A review. Pharmaceutics. 2021; 13(3): 316.
Loza Ye О, Homeliuk TM, Krynytska IYa, Marushchak MI. Study of changes of skin reparative ability of postoperative wounds in rats with streptozotocin-induced diabetes. Bull of Med and Biol Res. 2021; 3(2): 77-81. https://doi.org/10.11603/bmbr.2706-6290.2021.2.12342
» https://doi.org/10.11603/bmbr.2706-6290.2021.2.12342
Miller EJ, Matukas VJ. Chick cartilage collagen: A new type of alpha 1 chain not present in bone or skin of the species. Proc Natl Acad Sci USA. 1969; 64(4): 1264-1268.
Natrus L, Ryzhko I, Blazquez-Navarro A, Panova T, Zaychenko G, Klymenko O, et al. Correlational analysis of the regulatory interplay between molecules and cellular components mediating angiogenesis in wound healing under normal and hyperglycemic conditions. Clin Hemorh and Microcirc. 2021; 78(4): 379-390. https://doi.org/10.3233/CH-201077
» https://doi.org/10.3233/CH-201077
North ACT, Cowan PM, Randal JT. Structural units in collagen fibrils. Nature. 1954; 174: 1142-1143.
Paul C, Leser S, Oesser S. Significant amounts of functional collagen peptides can be incorporated in the diet while maintaining indispensable amino acid balance. Nutrients. 2019; 11(5): 1079.
Ramachandran GN, Kartha G. Structure of collagen. Nature. 1955; 176: 593-595.
Reilly D, Lozano J. Skin collagen through the lifestages: importance for skin health and beauty. Plast Aesthet Res. 2021; 8(2): 2347-9264.
Ricard-Blum S. The collagen family. Cold Spring Harb Perspect Biol. 2011; 3(1): a004978.
Rodríguez MI, Barroso L, Sánchez ML. Collagen: A review on its sources and potential cosmetic applications. J Cosmet Dermatol. 2018; 17(1): 20-26.
Rovira RH, Tuzhanskyy SY, Pavlov SV, Savenkov SN, Kolomiets IS, Stasenko VA, et al. Polarimetric characterisation of histological section of skin with pathological changes. Proceed of SPIE - The Intern Soc for Opt Eng. 2016; 10031: https://doi.org/100313E.10.1117/12.2249373
» https://doi.org/100313E.10.1117/12.2249373
Rotshtein A. Design and tuning of fuzzy rule-based systems for medical diagnosis. In: Fuzzy and Neuro-Fuzzy Systems in Medicine, pp. 243-289. CRC Press; 2017. https://doi.org/10.1201/9780203713419
» https://doi.org/10.1201/9780203713419
Sarafyniuk L, Stepanenko I, Khapitska O, Vlasenko R, Sarafyniuk P. Mathematical modelling of peripheral haemodynamics of the shin in volleyball players of mesomorphic somatotype. Bull Med Biol Res. 2023; 5(4): 62-70.
SCCS Notes of Guidance for the testing of cosmetic ingredients and their safety evaluation - 11th revision. 2021. https://health.ec.europa.eu/system/files/2021-04/sccs_o_250_0.pdf
» https://health.ec.europa.eu/system/files/2021-04/sccs_o_250_0.pdf
Schweitzer MH, Avci Z, Allen ZM, Arce FT, Horner JR. Analyses of soft tissue from Tyrannosaurus rex suggest the presence of protein. Science. 2007; 316(5822): 277-280.
Senadheera T, Dave D, Shahidi F. Sea cucumber derived type I collagen: A comprehensive review. Mar Drugs. 2020; 18(9): 471.
Shenoy M, Sayed N, Qamar Z, Musfer B, Zuhair K, Kakti A. Collagen structure, synthesis, and its applications: A systematic review. Cureus. 2022; 14(5): е24856.
Souto EB, Fangueiro JF, Fernandes AR, Cano A, Sanches-Lopez E, Garcia ML, et al. Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery. Heliyon. 2022; 8(2): е08938.
Sutterby E, Thurgood P, Baratchi S, Khoshmanesh K, Pirogova E. Evaluation of in-vitro human skin models for studying effects of external stressors and stimuli and developing treatment modalities. View. 2022; 3(2): 20210012.
van der Rest M, Garrone R. Collagen family of proteins. FASEB J. 1991; 5(13): 2814-2823.
Vollmer DL, West VA, Lephart ED. Enhancing skin health: By oral administration of natural compounds and minerals with implications to the dermal microbiome. Int J Mol Sci. 2020; 19(10): 3059.
Wang H. A review of the effects of collagen treatment in clinical studies. Polymers. 2021; 13(22): 3868.
Wu M, Cronin K, Crane JS. Biochemistry, collagen synthesis. StatPearls Publishing LLC; 2020.
Wyskoff R, Corney R, Biscoe J. X-ray reflections of long spacing from tendon. Science. 1935; 82(2121): 175-176.
Zhuang Y, Ruan S, Yao H, Sun Y. Physical properties of composite films from tilapia skin collagen with pachyrhizus starch and rambutan peel phenolics. Mar Drugs. 2019; 17(12): 662.
Žmitek K, Žmitek J, Butina MR, Pogačnik T. Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study. Nutrients. 2022; 12(3): 618.
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