Hymenaea rubriflora Ducke stem bark extract has vasorelaxant and contractile inhibition capacity

Authors

  • Alexandre Sérgio Silva Post-graduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil; Laboratory of Studies on Physical Training Applied to Performance and Health, Department of Physical Education, Federal University of Paraíba, João Pessoa, Paraíba, Brazil https://orcid.org/0000-0003-3576-9023
  • Lydiane de Lima Tavares Toscano Post-graduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil; Laboratory of Studies on Physical Training Applied to Performance and Health, Department of Physical Education, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Maria da Conceição Rodrigues Gonçalves Post-graduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Ângela Maria Tribuzy de Magalhães Cordeiro Center for Technology and Regional Development, Nucleus LACOM, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Rubens Teixeira de Queiroz Department of Systematics and Ecology, CCEN, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Bárbara Cavalcanti Barros Post-graduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Manoel Miranda Neto Post-graduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil; Laboratory of Studies on Physical Training Applied to Performance and Health, Department of Physical Education, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Ivyne Oliveira Araújo Wanderley Laboratory of Studies on Physical Training Applied to Performance and Health, Department of Physical Education, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Isabelle de Lima Brito Polari Center for Technology and Regional Development, Nucleus LACOM, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Iara Leão Luna de Souza Post-graduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Bagnólia Araújo Costa Post-graduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Luciana Tavares Toscano Post-graduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil; Laboratory of Studies on Physical Training Applied to Performance and Health, Department of Physical Education, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
  • Keyth Sulamitta de Lima Guimarães Post-graduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil; Laboratory of Studies on Physical Training Applied to Performance and Health, Department of Physical Education, Federal University of Paraíba, João Pessoa, Paraíba, Brazil

DOI:

https://doi.org/10.1590/

Keywords:

Antioxidant, Aorta, Hymenaea rubriflora ducke, Nitric oxide, Vasorelaxation

Abstract

We investigated the vasodilatory effects of Hymenaea rubriflora Ducke stem bark extract (HR- HAc). Vascular reactivity of the aortic rings of Wistar rats was tested by in vitro cumulative doses (0.1 - 729 μg/mL). Rats (n=5) were treated with 25 (G25), 50 (G50) and 100 (G100) mg/ kg of HR-HAc or saline (control group - CG) for four weeks. An in vitro assay resulted in dose-dependent relaxation of the aortic rings with functional endothelium, which was inhibited in the presence of L-NAME. Rings of the treated animals increased acetylcholine relaxing potency at all doses, with a greater effect on G50 (pD2 = 7.8±0.1, Emax = 95.6±1.1) and a decreased contractile potency to phenylephrine in G25 (pD2 = 6.9±0.06, Emax = 61.5±6.0%) and G50 (pD2= 6.6±0.06, Emax = 71.0±8.5%) when compared to the CG in the presence and absence of endothelium (pD2= 6.4± 0.1, 6.4±0.1 and 6.9±0.1, respectively). Cumulative doses of nitroprusside resulted in increased relaxing potency in all treated groups and maintained Emax at 100%. It is concluded that HR-HAc has vasorelaxant capacity and inhibitory vascular contraction activity applied either directly to aortic rings or after treatment with in vivo supplementation, which places this extract as a potential nutraceutical or pharmacological agent for treating diseases associated with vascular dysfunction.

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Published

2024-11-05

Issue

Vol. 60 (2024)

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Article

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How to Cite

Hymenaea rubriflora Ducke stem bark extract has vasorelaxant and contractile inhibition capacity. (2024). Brazilian Journal of Pharmaceutical Sciences, 60. https://doi.org/10.1590/

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