Biological properties of Schinus terebinthifolia Raddi essential oil

Priscilla Guimarães Silva  Vasconcelos; Érika Ponchet  Alves; Carolina Medeiros de Almeida  Maia; Arella Cristina Muniz  Brito; Diego Romário  Silva; Irlan Almeida  Freires; Yuri Wanderley  Cavalcanti; Vera Lucia Garcia  Rehder; Ana Lúcia Tasca Gois  Ruiz; Marta Cristina Teixeira  Duarte; Pedro Luiz  Rosalen; Gustavo Pina  Godoy; Edja Maria Melo de Brito  Costa

doi:10.1590/

Authors

Priscilla Guimarães Silva Vasconcelos Department of Dentistry, State University of Paraíba (UEPB), Campina Gande, PB, Brazil https://orcid.org/0000-0001-8975-7162
Érika Ponchet Alves Department of Dentistry, State University of Paraíba (UEPB), Campina Gande, PB, Brazil
Carolina Medeiros de Almeida Maia Department of Dentistry, State University of Paraíba (UEPB), Campina Gande, PB, Brazil
Arella Cristina Muniz Brito Department of Dentistry, State University of Paraíba (UEPB), Campina Gande, PB, Brazil
Diego Romário Silva Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil
Irlan Almeida Freires Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL United States
Yuri Wanderley Cavalcanti Department of Clinical and Social Dentistry, Federal University of Paraíba (UFPB), João Pessoa, PB, Brazil https://orcid.org/0000-0002-3570-9904
Vera Lucia Garcia Rehder Center for Chemical Biological and Agricultural Research, University of Campinas (UNICAMP), Paulínia, SP, Brazil
Ana Lúcia Tasca Gois Ruiz Center for Chemical Biological and Agricultural Research, University of Campinas (UNICAMP), Paulínia, SP, Brazil ; Faculty of Pharmaceutical Sciences, University of Campinas, UNICAMP, Campinas, SP, Brazil
Marta Cristina Teixeira Duarte Center for Chemical Biological and Agricultural Research, University of Campinas (UNICAMP), Paulínia, SP, Brazil
Pedro Luiz Rosalen Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil
Gustavo Pina Godoy Department of Dentistry, State University of Paraíba (UEPB), Campina Gande, PB, Brazil
Edja Maria Melo de Brito Costa Department of Dentistry, State University of Paraíba (UEPB), Campina Gande, PB, Brazil https://orcid.org/0000-0002-3166-709X

DOI:

https://doi.org/10.1590/

Keywords:

Anacardiaceae, Medicinal plants, Products with antimicrobial action, Toxicity test

Abstract

Schinus terebinthifolia Raddi green fruits essential oil (EO) was evaluated regarding its phytochemical profile, antimicrobial and cytotoxic activities, and toxicity. Gas chromatography with mass spectrometry was applied to identify its constituents, thereafter the minimum inhibitory concentration, minimum bactericidal and fungicidal concentrations, and its antibiofilm activity were evaluated. The EO cytotoxicity was assessed in tumor and non-tumor human cells, and in vivo toxicity was evaluated in a Galleria mellonella model. The major constituents of S. terebinthifolia EO were alpha-phellandrene and beta-phellandrene. The EO had a weak activity against all strains of Candida albicans (MIC 1000μg/mL) and had no activity against non-albicans strains, bacteria, and C. albicans biofilm. Cytostatic activity against all tumor cell lines was shown. Additionally, cell viability remained at EO concentrations up to 62.5 μg/mL. At 16 mg/mL, 50% hemolysis was observed, and it had low toxicity in vivo. Overall, the S. terebinthifolia EO was characterized by low antimicrobial and antibiofilm activities, with no evidence of toxicity to human tumor and non-tumor cells.

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