Doxorubicin cardiotoxicity and Camellia sinensis cardioprotection determined by speckle-tracking echocardiography

Authors

  • Maira Souza Oliveira Barreto Departamento de Medicina Veterinária, Universidade Federal de Lavras, Lavras, Brasil
  • Juliana Lott Carvalho Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
  • Marcos Barrouin Melo Departamento de Fisiologia e Farmacologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
  • Ana Flávia Ribeiro Machado Michel Departamento de Ciências Agrárias e Ambientais, Universidade Estadual de Santa Cruz, Ilhéus, BA, Brasil
  • Marina Guimarães Ferreira Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
  • Ruthnéa Aparecida Lázaro Muzzi Departamento de Medicina Veterinária, Universidade Federal de Lavras, Lavras, Brasil
  • Alfredo Miranda de Goes Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
  • Marilia Martins Melo Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil https://orcid.org/0000-0003-3630-6776

DOI:

https://doi.org/10.1590/

Keywords:

Flavonoids;, Green tea;, Heart injury;, Radial strain;, Longitudinal strain

Abstract

Doxorubicin (Dox) is a medication used in the treatment of cancerous tumors and hematologic malignancies with potentially serious side effects, including the risk of cardiotoxicity. Flavonoids are plant metabolites with antioxidant properties and can be extracted from Camellia sinensis (CS). The aim of this study is to evaluate the possible cardioprotective effect of CS against injuries induced by Dox in rats. A total of 32 animals were distributed into four groups: (1) control - intraperitoneal injection (I.P.) of 0.5 mL saline weekly and 1.0 mL water by gavage daily; (2) CS - 0.5 mL saline I.P. weekly and 200 mg/kg CS by gavage daily; (3) Dox - 5.0 mg/kg Dox I.P. weekly and 1.0 mL water by gavage daily; and (4) Dox+CS -5.0 mg/kg Dox I.P. weekly and 200 mg/kg CS by gavage daily. Clinical examinations, blood profiles, electrocardiograms, echocardiograms, and histological analyses of hearts were performed over 25 days. The animals in the Dox group showed changes in body weight and in erythrogram, leukogram, electrocardiography, and echocardiography readings. However, animals from the dox+CS group had significantly less change in body weight, improved cardiac function, and showed more preserved cardiac tissue. This study demonstrated that CS prevents dox-induced cardiotoxicity, despite enhancing the cytotoxic effect on blood cells.

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Published

2023-08-28

Issue

Vol. 59 (2023)

Section

Article

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How to Cite

Doxorubicin cardiotoxicity and Camellia sinensis cardioprotection determined by speckle-tracking echocardiography. (2023). Brazilian Journal of Pharmaceutical Sciences, 59, 14. https://doi.org/10.1590/