Process optimization of physicochemical properties of spray-dried Hydrocotyle umbellata L. extract

Matheus Gabriel de Oliveira; Guilherme Gomes  Moreira; Andressa Tuane Santana  Paz; Thiago Levi Silva  Oliveira; Luís Antônio Dantas  Silva; Edemilson Cardoso da  Conceição; Leonardo Luiz  Borges; Vinicius Barreto da Silva; José Realino de  Paula

doi:10.1590/s2175-97902023e21211

Authors

Matheus Gabriel de Oliveira Universidade Federal de Goiás, Goiânia, Brasil
Guilherme Gomes Moreira Universidade Federal de Goiás, Goiânia, Brasil https://orcid.org/0000-0003-1162-6511
Andressa Tuane Santana Paz Universidade Federal de Goiás, Goiânia, Brasil https://orcid.org/0000-0002-2754-7474
Thiago Levi Silva Oliveira Universidade Federal de Goiás, Goiânia, Brasil https://orcid.org/0000-0003-3848-5261
Luís Antônio Dantas Silva Universidade Federal de Goiás, Goiânia, Brasil https://orcid.org/0000-0001-5328-237X
Edemilson Cardoso da Conceição Universidade Federal de Goiás, Goiânia, Brasil https://orcid.org/0000-0003-4113-2686
Leonardo Luiz Borges Pontifícia Universidade Católica de Goiás. Universidade Estadual de Goiás, Goiânia, Brasil https://orcid.org/0000-0003-2183-3944
Vinicius Barreto da Silva Pontifícia Universidade Católica de Goiás, Goiânia, Brasil https://orcid.org/0000-0002-5066-7431
José Realino de Paula Universidade Federal de Goiás, Goiânia, Brasil https://orcid.org/0000-0002-4424-7692

DOI:

https://doi.org/10.1590/s2175-97902023e21211

Keywords:

Anxiety, Medicinal plants, Phytotherapy, Powder properties, Spray drying

Abstract

Hydrocotyle umbellata L., Araliaceae, is a species that is recommended in Ayurvedic medicine for its effects on the central nervous system, such as anxiolytic and memory-stimulant effects. Despite the medicinal potential of this species, its phytopharmaceutical and technological potential to produce standardized extracts has not been investigated. This study analyzes the influence of spray drying parameters on the contents of the chemical markers (total phenolic, total flavonoid, and hibalactone) and the functional properties of H. umbellata extract. The optimization of drying conditions was performed using a central composite design combined with response surface methodology and desirability function approach. The mathematical models fitted to experimental data indicated that all the evaluated drying parameters significantly influenced the chemical contents. The optimal conditions were: inlet temperature of 120 °C, feed flow rate of 4 mL min^-1, and colloidal silicon dioxide:maltodextrin ratio of 16%:4%. Under these conditions, the powder samples had spherical particles and desirable physicochemical and functional properties, such as low water activity and moisture content, good product recovery, reconstitution, and flowability. Thus, spray drying might be a promising technique for processing standardized H. umbellata extracts.

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Process optimization of physicochemical properties of spray-dried Hydrocotyle umbellata L. extract

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