The activity of propolis against pathogenic fungi isolated from human infections

Katarzyna  Wolska; Katarzyna  Antosik

doi:10.1590/s2175-97902023e19978

Authors

Katarzyna Wolska University of Natural Sciences and Humanities https://orcid.org/0000-0002-6638-9552
Katarzyna Antosik University of Natural Sciences and Humanities

DOI:

https://doi.org/10.1590/s2175-97902023e19978

Keywords:

Propolis, Antifungal activity , Human infections

Abstract

Propolis is a resinous hive product collected by bees from the buds or other parts of plants. It is known for having various biological properties, including antifungal activity. Among the substances present in propolis, flavonoids and phenolic acids and their esters are responsible for its antifungal properties. This means that propolis is ideal for use as an antifungal agent in alternative medicine to treat a number of both topical and systemic infections caused by Candida species and other yeast-like fungi, dermatophyte and nondermatophyte moulds, without the serious side effects typical of synthetic treatment. It is also active against strains of fungi that are resistant to polyenes and azoles, the classes of drugs most commonly used to treat fungal infections. In this article, we review current knowledge about the activity of propolis from different parts of the world and its components in vitro and in vivo against pathogenic fungi isolated from human infections. The article also indicates the possible mechanism of antifungal activity of propolis and its components.

Downloads

Download data is not yet available.

References

Astani A, Zimmermann S, Hassan E, Reichling J, Sensch KH, Schnitzler P. Antimicrobial activity of propolis special extract GH 2002 against multidrug-resistant clinical isolates. Pharmazie. 2013;68(8):695-701.

Bankova VS, Boudourova-Krasteva G, Sforcin JM, Frete X, Kujumgiev A, Maimoni-Rodella R, et al. Phytochemical evidence for the plant origin of Brazilian propolis from São Paulo State. Z Naturforsch. 1999;54(5-6):401-405.

Bankova VS, de Castro SL, Marcucci MC. Propolis: recent advances in chemistry. Apidologie. 2000;31:3-15.

Buchta V, Černý J, Opletalová V. In vitro antifungal activity of propolis samples of Czech and Slovak origin. Cent Eur J Biol. 2011;6(2):160-166.

Burdock GA. Review of the biological properties and toxicity of bee propolis. Food Chem Toxicol. 1998;36(97):347-363.

Capistrano HM, de Assis EM, Leal RM, Alvarez-Leite ME, Brener S, Bastos EMAF. Brazilian green propolis compared to miconazole gel in the treatment of Candida-associated denture stomatitis. Evid Based Complement Alternat Med Volume 2013, Article ID 947980, 6 pages.

Castaldo S, Capasso F. Propolis, an old remedy used in modern medicine. Fitoterapia. 2002;73(02):1-6.

Chamandi G, Olama Z, Holail H. Antimicrobial effect of propolis from different geographic origins in Lebanon. Int J Curr Microbiol App Sci. 2015;4(4):328-342.

Chee HY. In vitro evaluation of the antifungal activity of propolis extract on Cryptococcus neoformans and Candida albicans Mycobiology. 2002;30(2):93-95.

Dalben-Dota KF, Consolaro MEL, Svidzinski TIE, Bruschi ML. Antifungal Activity of Brazilian propolis microparticles against yeasts isolated from vulvovaginal candidiasis Evid Based Complement Alternat Med Volume 2011, Article ID 201953, 8 pages.

D’Auria FD, Tecca M, Scazzocchio F, Renzini V, Strippoli V. Effect of propolis on virulence factors of Candida albicans J Chemother. 2003;15(05):454-460.

De Carvalho Duailibe SA, Goncalves AG, Mendes Ahid FJ. Effect of a propolis extract on Streptococcus mutans counts in vivo J Appl Oral Sci. 2007;15(05):420-423.

Diba K, Mahmoudi M, Hashemi J. In vitro activity of propolis alcoholic extract on opportunistic pathogenic fungi. Int J Res Appl Basic Med Sci. 2018;4(2):68-73.

Dias SMD, Gomes RT, Santiago WK, Paula AMB, Cortés ME, Santos VR. Antifungal activity of commercial ethanolic and aqueous extracts of Brazilian propolis against Candida spp. Rev Ciênc Farm Básica Apl. 2009;28(3):259-263.

El-Shouny W, Muagam F, Sadik Z, Hamza W. Antimicrobial activity of propolis extract on URT infections in pediatric patients admitted to Al-Thowrah Hospital, Hodeidah City, Yemen. World J Med Sci. 2012;7(3):172-177.

Farnesi AP, Aquino Ferreira R, De Jong D, Bastos JK, Soares AE. Effects of stingless bee and honey bee propolis on four species of bacteria. Genet Mol Res. 2009;8(2):635-640.

Ghannoum MA, Rice LB. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev. 1999;12(4):501-517.

Ghisalberti EL. Propolis: A review. Bee World. 1979;60:59-84.

Gucwa K, Kusznierewicz B, Milewski S, Van Dijck P, Szweda P. Antifungal activity and synergism with azoles of polish propolis. Pathogens. 2018;7(02):56.

Hegazi AG, El Hadyb F, Alla F. Chemical composition and antimicrobial activity of european propolis. Z Naturforsch . 2000;55(1-2):70-75.

Holderna E, Kędzia B. Investigation upon the combined action of propolis and antimycotic drugs on Candida albicans Herba Pol.1987;33:145-151.

Khalil ML. Biological activity of bee propolis in health and disease. Asian Pac J Cancer Prev. 2006;7(1):22-31.

Koo H, Gomes BP, Rosalen PL, Ambrosano GM, Park YK, Cury JA. In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens. Arch Oral Biol. 2000;45(2):141-148.

Kujumgiev A, Tsvetkova I, Serkedjieva Y, Bankova V, Christov R, Popova S. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. J Ethnopharmacol. 1999;64(3):235-2340.

López SN, Castelli MV, Zacchino SA, Dominguez JN, Lobo G, Charris-Charris J, et al. In vitro antifungal evaluation and structure activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall. Bioorg Med Chem. 2001;9(8):1999-2013.

Mello BCBS, Petrus JCC, Hubinger MD. Concentration of flavonoids and phenolic compounds in aqueous and ethanolic propolis extracts through nanofiltration. J Food Eng. 2010;96(4):533-539.

Mello AM, Gomes RT, Lara SR, Gomes Silva L, Alve JB, Cortes ME, et al. The effect of Brazilian propolis on the germ tube formation and cell wall of Candida albicans Pharmacology online. 2006;3:352-358.

Metzner J, Schneidewind EM, Friedrich E. Effect of propolis and pinocembrin on fungi. Pharmazie. 1977;32(11):730.

Montero JC, Mori GG. Assessment of ion diffusion from a calcium hydroxide propolis paste through dentin. Braz Oral Res. 2012;26(4):318-322.

Oliveira AC, Shinobu CS, Longhini R, Franco SL, Svidzinski TI. Antifungal activity of propolis extract against yeasts isolated from onychomycosis lesions. Mem Inst Oswaldo Cruz. 2006;101(5):493-497.

Ota C, Unterkircher C, Fantinato V, Shimizu MT. Antifungal activity of propolis on different species of Candida Mycoses. 2001;44(9-10):375-378.

Peng L, Yang S, Cheng YJ, Chen F, Pan S, Fan G. Antifungal activity and action mode of pinocembrin from propolis against Penicillium italicum Food Sci Biotechnol. 2012;21(6):1533-1539.

Roh J, Kim KR. Antimicrobial Activity of Korean Propolis Extracts on Oral Pathogenic Microorganisms. J Dent Hyg Sci. 2018;18(1):18-23.

Santos VR, Pimenta FJGS, Aguiar MCF, Do Carmo MAV, Naves MD, Mesquita RA. Oral candidiasis treatment with Brazilian ethanol propolis extract. Phytother Res. 2005;19(7):652-654.

Santos VR, Gomes RT, de Mesquita RA, de Moura MD, França EC, de Aguiar EG, et al. Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study. Phytother Res . 2008;22(11):1544-1547.

Sariguzel FM, Berk E, Koc AN, Sav H, Demir G. Antifungal activity of propolis against yeasts isolated from blood culture: in vitro evaluation. J Clin Lab Anal. 2016;30(5):513-516

Sawaya AC, Palma AM, Caetano FM, Marcucci MC, da Silva Cunha IBS, Araujo CEP, et al. Comparative study of in vitro methods used to analyse the activity of propolis extracts with different compositions against species of Candida Lett Appl Microbiol. 2002;35(3):203-207.

Sforcin JM, Fernandes Jr A, Lopes CAM, Bankova V, Funari SRC. Seasonal effect on Brazilian propolis antibacterial activity. J Ethnopharmacol . 2001;73(1-2):243-249.

Sforcin JM, Bankova V. Propolis: is there a potential for the development of new drugs. J Ethnopharmacol . 2011;133(2):253-260.

Shehu A, Ismail S, Rohin MAK, Harun A, Aziz AA, Haque M. Antifungal properties of Malaysian Tualang honey and stingless bee propolis against Candida albicans and Cryptococcus neoformans J Appl Pharm Sci. 2006;6(02):044-050.

Silva FRG, Matias TMS, Souza LIO, Matos-Rocha TJ, Fonesca SA, Mousinho KC, et al. Phytochemical screening and in vitro antibacterial, antifungal, antioxidant and antitumor activities of the red propolis Alagoas. Braz J Biol. 2019;79(3):452-459.

Siqueira AB, Gomes BS, Cambuim I, Maia R, Abreu S, Souza-Motta CM, et al. Trichophyton species susceptibility to green and red propolis from Brazil. Lett Appl Microbiol . 2009;48(1):90-96.

Siqueira ABS, de Araújo Rodriquez LRN, Santos RKB, Marinho RRB, Sheila Abreu S, Peixoto RF, et al. Antifungal activity of propolis against Candida species isolated from cases of chronic periodontitis Braz Oral Res . 2015;29(1):1-6.

Soares MMSR, Cury AE. In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis. Braz J Microbiol.2001;32:130-134.

Stan T, Teodor ED, Gatea F, Chifiriuc MC, Lazar V. Antioxidant and antifungal activity of Romanian propolis. Roman Biotechnol Lett. 2017;22(6):13116-13124.

Takaisi-Kikuni NB, Schilcher H. Electron microscopic and microcalorimetric investigations of the possible mechanism of the antibacterial action of a defined propolis provenance. Planta Med. 1994;60(3):222-227.

Tlak Gajger I, Pavlovic I, Bojic M, Kosalec I, Sreces S, Vlainic T, et al. The components responsible for the antimicrobial activity of propolis from continental and mediterranean regions in Croatia. Czech J Food Sci. 2017;35(5):376-385.

Veiga FF, Gadelha MC, da Silva MRT, Costa MI, Kischkel B, de Castro-Hoshino LV, et al. Propolis extract for onychomycosis topical treatment: from bench to clinic. Front Microbiol. 9:779.doi:10.3389/fmicb. 2018.00779. eCollection. 2018.

» https://doi.org/10.3389/fmicb. 2018.00779

Wolska K, Górska A, Adamiak A. Antibacterial properties of propolis (In Polish). Post Mikrobiol. 2016;55(4):343-350.

Wolska K, Górska A, Antosik K, Ługowska K. Immunomodulatory effects of propolis and its components on basic immune cell functions. Indian J Pharm Sci. 2019;81(4):575-588.

Yusoff NYN, Mohamad S, Abdullah HN, Rahmana NA. Antifungal Activity of Malaysian honey and propolis extracts against pathogens implicated in denture stomatitis AIP Conf Proc. 2016;1791:020006-1-020006-7; doi: 10.1063/1.4968861

» https://doi.org/10.1063/1.4968861