Evaluation of copaiba oil as enhancer of ibuprofen skin permeation

Rodrigo Lupatini; Richard Grazul; Ademar Alves da Silva Filho; Jorge Willian Leandro Nascimento

doi:10.1590/s2175-97902022e19548

Authors

Rodrigo Lupatini Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil
Richard Grazul Department of Chemistry, Institute of Exact Sciences, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil
Ademar Alves da Silva Filho Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil https://orcid.org/0000-0002-9096-1336
Jorge Willian Leandro Nascimento Department of Pharmacology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil https://orcid.org/0000-0002-0334-0217

DOI:

https://doi.org/10.1590/s2175-97902022e19548%20

Keywords:

Copaiba oil, Terpenes, Ibuprofen, Penetration enhancer, Pig skin

Abstract

The administration of medications on the skin through transcutaneous routes is a practice that has been used by mankind for millennia. Some studies have been reporting the use of terpenes and natural oils rich in terpenes as an enhancer of cutaneous penetration. Copaiba oil, due to its rich content of terpenes, presents itself as a great choice of penetration enhancer for drugs administered on the skin. In this study, we developed two cream formulations containing 5% of ibuprofen (IBU) and copaiba oil: IBCO5 and IBCO10 with 5% and 10% of copaiba oil respectively. Ex vivo cutaneous penetration/permeation studies of IBU were performed using pig ear skin as biological membrane in the Franz-type diffusion cells. The steady-state flux of IBU samples, IBCO5 (35.72 ± 6.35) and IBCO10 (29.78 ± 2.41) were significantly higher when compared with control without copaiba oil (10.32 ±1.52) and with a commercial product (14.44 ± 2.39). In the penetration analysis, the amount of IBU found in the samples IBCO5 and IBCO10 was markedly higher in the dermis than epidermis. Our results showed that copaiba oil possesses attracting properties in promoting skin penetration and permeation of IBU when added into cream formulations.

Downloads

References

Adams RP. Identification of essential oil components by gas chromatography/mass spectrometry. Allured Publishing Corporation: Carol Stream; 2007. 457p.

Bello AI, Kuwornu S. 5% Ibuprofen iontophoresis compared with transcutaneous eletrical nerve stimulation in the management of knee osteoarthritis: a feasibility study. Op J Ther Rehab. 2014;2(4):166-172.

British Pharmacopoeia, The Stationery Office: London; 2014.

Chen J, Jiang Q, Chai Y, Zhang H, Peng P, Yang X. Natural terpenes as penetration enhancers for transdermal drug delivery. Molecules. 2016;21(12):1709.

Custodio DL, Veiga-Junior VF. True and common balsams. Rev Bras Farmacogn. 2012;22(6):1372-1383.

Dias DS, Fontes LBA, Crotti AEM, Aarestrup BJV, Aarestrup FM, Da Silva Filho AA, Corrêa JOA. Copaiba oil suppresses inflammatory cytokines in splenocytes of C57B1/6 mice induced with Experimental Autoimmune Encephalomyelitis (EAE). Molecules. 2014;19(8):12814-12826.

Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. Ibuprofen transport into and through skin from topical formulations: In vitro - In vivo comparison. J Invest Dermatol. 2007;127(1):135-142.

Herman A, Herman AP. Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review. J Pharm Pharmacol. 2015;67(4):473-485.

Hussain A, Khan GM, Shah SU, Shah KU, Rahim N, Wahab A, Rehman AU. Development of a novel ketoprofen transdermal patch: Effect of almond oil as penetration enhancers on in vitro and ex vivo penetration of ketoprofen through rabbit skin. Pak J Pharmac Sci. 2012;25(1):227-232.

Jiang Q, Wu Y, Zhang H, Liu P, Yao J, Yao P, et al. Development of essential oils as skin permeation enhancers: penetration enhancement effect and mechanism of action. Pharm Biol. 2017;55(1):1592-1600.

Khan NR, Khan GM, Wahab A, Khan AR, Hussain A, Nawaz A, et al. Formulation, and physical, in vitro and ex vivo evaluation of transdermal ibuprofen hydrogels containing turpentine oil as penetration enhancer. Pharmazie. 2011;66(11):849-852.

Lan Y, Li H, Chen Y, Zhang Y, Liu N, Zhang Q, et al. Essential oil from Zanthoxylum bungeanum Maxim. and its main components used as transdermal penetration enhancers: a comparative study. J Zhejiang Univ Sci B. 2014;15(11):940-52.

Leandro L, Vargas FS, Barbosa PCS, Neves JKO, Silva JA, Veiga-Junior VF. Chemistry and biological activities of terpenoids from copaiba (Copaifera spp.) Oleoresins. Molecules. 2012;17(4):3866-3889.

Lucca LG, Matos SP, Borille BT, Dias DO, Teixeira HF, Veiga-Junior VF, et al. Determination of β-caryophyllene skin permeation/retention from crude copaiba oil (Copaifera multijuga Hayne) and respective oil-based nanoemulsion using a novel HS-GC/MS method. J Pharm Biolmed Anal. 2015;104:144-148.

McLafferty FW. Wiley Registry of Mass Spectral Data, 8th ed., New York: Hoboken, John Wiley & Sons; 2008.

Monti D, Chetoni P, Burgalassi S, Najarro M, Saettone MF, Boldrini E. Effect of different terpene-containing essential oils on permeation of estradiol through hairless mouse skin. Int J Pharmac. 2002;237(1-2):209-214.

Obata Y, Ashitaka Y, Kikuchi S, Isowa K, Takayama K.. A statistical approach to the development of a transdermal delivery system for ondansetron. Int J Pharm. 2010;399(1-2):87-93.

Oliveira RVM, Ohara MT, Vila MMDC, Gonçalves MM. In vitro evaluation of copaiba oil as a kojic acid skin enhancer. Braz J Pharm Sci. 2010;46(2):363-370.

Padula C, Nicoli S, Santi P. In vitro evaluation of bioadhesive films containing ibuprofen. Anti-Inflam Anti-Aller Ag Medic Chem. 2011;10(3):240-245.

Pontrelli G, Monte F. A two-layer model for transdermal drug delivery and percutaneous absorption. Math Biosci. 2014;257:96-103.

Ruela ALM, Perissinato AG, Lino MES, Mudrik PS, Pereira GR. Evaluation of skin absorption of drugs from topical and transdermal formulations. Braz J Pharmac Sci. 2016;52(3):527-544

Santis AK, Freitas ZMF, Ricci-Junior E, Brito-Gitirana L, Fonseca LB, Santos EP. Nifedipine in semi-solid formulations for topical use in peripheral vascular disease: preparation, characterization, and permeation assay. Drug Develop Ind Pharm. 2012;39(7):1098-1106.

Sarkar AB, Dudley R, Melethil S, Speidel J, Markandakumar B. Chemical stability of hydrocortisone in topical preparation in proprietary VersaProTM cream base. Innov Pharm. 2011;2(3):1-3.

Sato MEO, Gomara F, Pontarolo R, Andreazza IF, Zaroni M. Permeação cutânea in vitro do ácido kójico. Braz J Pharmac Sci . 2007;43(2):195-203.

Simon A, Amaro MI, Healy AM, Cabral LM, Sousa VP. Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation. Int J Pharm. 2016;512(1):234-241.

Stahl J, Wohlert M, Kietzmann M. The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen. BMC Pharmacol. 2011;11(12):1-5.

Veiga-Junior VF, Rosas EC, Carvalho MV, Henriques MGMO, Pinto AC. Chemical composition and anti- inflammatory activity of copaiba oils from Copaifera cearensis Huber ex Ducke, Copaifera reticulate Ducke and Copaifera multijuga Hayne - A comparative study. J Ethnopharmacol. 2007;112(2):248-254.

Yuan X, Capomacchia AC. The binary eutectic of NSAIDs and two-phase liquid system for enhanced membrane permeation. Pharmac Develop Techn. 2005;10(1):1-10.

Zamarioli CM, Martins RM, Carvalho EC, Freitas LAP. Nanoparticles containing curcuminoids (Curcuma longa): development of topical delivery formulation. Rev Bras Farmacogn . 2015;25(1):53-60.

Evaluation of copaiba oil as enhancer of ibuprofen skin permeation

Authors

DOI:

Keywords:

Abstract

Downloads

References

Downloads

Published

Issue

Section

License

How to Cite

Funding data