Effect of rape flower on benign prostatic hyperplasia in rats
DOI:
https://doi.org/10.1590/s2175-97902019000418785Keywords:
Rape flower, Rapeseed, BPH, LUTS, TGF-β1Abstract
We were carried out to investigate the efficacy of Rape (Rapeseed, Brassica napus L.) flower on BPH (benign prostatic hyperplasia) in rats. We found that the extract from Rape flower prevented hyperplasia in testosterone-induced BPH model, the relevant animal model of human BPH. Extract reduced the weight of prostate and induced significantly cell apoptosis in prostate in BPH model. In addition, the extract controlled expression of TGF-β1 in prostate gland and promoted urinary output in dose-dependence in BPH model. Our data provide that Rape flower may be useful for treatment of BPH.
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Altavilla D, Minutoli L, Polito F, Irrera N, Arena S, Magno C, et al. Effects of flavocoxid, a dual inhibitor of COX and 5-lipoxygenase enzymes, on benign prostatic hyperplasia. Br J Pharmacol. 2012;167(1):95-108.
Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol. 1984;132(3):474-479.
Bozec A, Ruffion A, Decaussin M, Andre J, Devonec M, Benahmed M, Mauduit C. Activation of caspases-3, -6, and -9 during finasteride treatment of benign prostatic hyperplasia. J Clin Endocrinol Metab. 2005;90(1):17-25.
Cayatte C, Pons C, Guigonis J-M, Pizzol J, Elies L, Kennel P, Rouquie D, Bars R, Rossi B, Samson M. Protein profiling of rat ventral prostate following chronic finasteride administration: identification and localization of a novel putative androgen-regulated protein. Mol Cell Proteomics. 2006;5(11):2031-43.
Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162(1):156-159.
Geller J, Angrist A, Nakao K, Newman H. Therapy with progestational agents in advanced benign prostatic hypertrophy. JAMA. 1969;210(8):1421-1427.
Gu H, Dong ZX, Wang CB, Yuan YF, Hou JH. Role of bFGF and TGF-β 1 in primary cultured prostatic stromal cells. Zhonghua Nan Ke Xue. 2006;12(10):917-22.
Han HY, Shan S, Zhang X, Wang NL, Lu XP, Yao XS. Down-regulation of prostate specific antigen in LNCaP cells by flavonoids from the pollen of Brassica napus L. Phytomedicine. 2007;14(5):338-43.
Ho CK, Habib FK. Estrogen and androgen signaling in the pathogenesis of BPH. Nat Rev Urol. 2011;8(1):29-41.
Kingston RE. Preparation and analysis of RNA, In: Ausubel FM, Brent R, Kinston RE, et al. (editors). Short protocols in molecular biology. John Wiley & Sons; 1995. p. 4-27.
Lepor H. The role of gonadotropin-releasing hormone antagonists for the treatment of benign prostatic hyperplasia. Rev Urol. 2006;8(4):183-189.
OED Online. Dictionary.oed.com. Retrieved 2012-04-22. Available from: Available from: http://eol.org/pages/583918/details.
» http://eol.org/pages/583918/details.
Orsted DD, Bojesen SE. The link between benign prostatic hyperplasia and prostate cancer. Nat Rev Urol. 2013;10(1): 49-54.
Rick FG, Abi-Chaker A, Szalontay L, Perez R, Jaszberenyi M, Jayakumar AR, et al. Shrinkage of experimental benign prostatic hyperplasia and reduction of prostatic cell volume by a gastrin-releasing peptide antagonist. Proc Natl Acad Sci U S A. 2013;110(7):2617-2622.
Roehrborn CG. Male lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Med Clin North Am. 2011;95(1):87-100.
Scolnik MD, Servadio C, Abramovici A. Comparative study of experimentally induced benign and atypical hyperplasia in the ventral prostate of different rat strains. J Androl. 1994;15(4):287-297.
Ståhlberg A, Håkansson J, Xian X, Semb H, Kubista M. Properties of the reverse transcription reaction in mRNA quantification. Clin Chem. 2004;50(3):509-515.
Van Coppenolle F, Slomianny C, Carpentier F, Le Bourhis X, Ahidouch A, Croix D, et al. Effects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence. Am J Physiol Endocrinol Metab. 2001;280(1):E120-129.
Wu YD, Lou YJ. Brassinolide, a plant sterol from pollen of Brassica napus L., induces apoptosis in human prostate cancer PC-3 cells. Pharmazie. 2007;62(5):392-5.
Yu JP, Wu XM, Chen JG, Liu WM, Yang QX. Analysis of serum insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in benign prostatic hyperplasia. Zhonghua Nan Ke Xue. 2003;9(5):341-3.
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