Compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant content
DOI:
https://doi.org/10.1590/s2175-97902022e191088%20%20Keywords:
Microemulsion, Nanocomposition, Formulation, Excipient, StabilityAbstract
The objective of this study was to determine the influence of nonionic surfactants on the effectiveness of preservatives used in emulsions containing high surfactant content. Mixtures of different concentrations were prepared between polyethoxylated (40) hydrogenated castor oil (PHCO) and polyoxyethylene sorbitan monooleate (PSO), with methylparaben, phenoxyethanol, methylparaben, ethylparaben, propylparaben, and isobutylparaben (PMEPBI) blend, phenoxyethanol and benzoic acid (BP) blend, and phenoxyethanol and caprylyl glycol (PC) blend. Subsequently, the compatibility of the formulation ingredients and the effectiveness of the preservatives were evaluated by the challenge test. It was found that PHCO and PSO inactivated the antimicrobial action of methylparaben and PMEPBI. Paraben-free preservatives BP and PC had less influence on surfactants than systems containing parabens. When incorporated into microemulsions and nanoemulsions containing 40% and 20% surfactants, methylparaben and BP 0.2% and 0.5% were only effective against Aspergillus niger. The PMEPBI 0.2% was effective as a preservative in nanoemulsified formulations against A. niger, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The results demonstrate that the efficacy of the preservative system in formulations containing nonionic surfactant excipients depends on the type of excipient, the components of the formulation, the preservative systems composition, the excipient to preservative ratio, and the availability in the formulation.
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References
Akers, MJ. Excipient-Drug Interactions in Parenteral Formulations. J Pharm Sci. 2002;91(11):2283-300.
Allen Jr LV, Poppovich NG, Ansel HC. Ansel’s pharmaceutical dosage forms and drug delivery systems. 10th ed., Philadelphia, PA, USA: Lippincott/Wolter Kluwer Health. 2013.
Blanchard J. Effect of polyols on interaction of paraben preservatives with polysorbate 80. J Pharm Sci . 1980;69(2):169-173.
Brasil. Agência Nacional de Vigilância Sanitária. Farmacopeia Brasileira. 5th ed. Brasília: ANVISA. 2010.
Clinical and Laboratory Standards Institute CLSI. Reference method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi. Approved Standard. Second Edition. CLSI document M38-A2. Wayne: CLSI. 2008a.
Clinical and Laboratory Standards Institute CLSI. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeast. Approved Standard. CLSI document M27-A3. Wayne: CLSI . 2008b.
Clinical and Laboratory Standards Institute CLSI. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. Approved Standard. 10th ed. CLSI document M07-A10. Wayne: CLSI . 2015.
Doron S, Friedman M, Falach M, Sadovnic E, Zvia H. Antibacterial effect of parabens against planktonic and biofilm Streptococcus sobrinus Int J Antimicrob Agents. 2001;18(6):575-578.
Elder DP, Crowley PJ. Antimicrobial Preservatives. Part Two: Choosing a Preservative. American Pharmaceutical Review. USA (2017). Available in: https://www.americanpharmaceuticalreview.com/Featured-Articles/343543-Antimicrobial-Preservatives-Part-Two-Choosing-a-Preservative/ > Accessed at November, 2021.
Kurup TRR, Wan LSC, Chan LW. Effect of surfactants on the antibacterial activity of preservatives. Pharm Acta Helv. 1991;66(9-10):274-280.
Müller AFF, Silva DCS, MacDonald R, Bonomini TJ, Machado, MS, Yunes RA, et al. Establishment of an HPLC-PDA method for analysis of derivative products from the flowers of Allamanda cathartica J Chem Pharm Res. 2015;7(10):250-256.
Narayanan M, Sekar P, Pasupathi M, Mukhopadhyay T. Self-preserving personal care products. Int J Cosmet Sci. 2017;39(3):301-309.
Nemes D, Kovács R, Nagy F, Mező M, Poczok N, Ujhelyi Z, et al. Interaction between different pharmaceutical excipients in liquid dosage forms-assessment of cytotoxicity and antimicrobial activity. Molecules. 2018;23(7):E1827. Available from: DOI: 10.3390/molecules23071827.
» https://doi.org/10.3390/molecules23071827
Pinto TJA, Kaneko TM, Pinto AF. Controle biológico de qualidade de produtos farmacêuticos, correlatos e cosméticos. 4th ed. São Paulo: Manole; 2015.
Santos ALR. The preservative system evaluation formulation with hydroalcoholic extract of Schinus terebinthifolius Raddi - Anacerdiaceae. [Master's dissertation]. Natal: Universidade Federal do Rio Grande do Norte. 2007.
Sheskey PJ, Cook WG, Cable CG. Handbook of Pharmaceutical Excipients. 8th ed. London: Pharmaceutical Press. 2017.
Smaoui S, Hlima HB. Effects of parabens and isothiazolinone on the microbiological quality of baby shampoo: the challenge test. Biocontrol Sci. 2012;17(3):135-142.
Steinberg DC. Preservatives for Cosmetics. 3th ed. Carol Stream: Allured Publishing Corporation. 2012.
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