Protective effect of luteolin on the transgenic Drosophila model of Parkinson’s disease

Authors

  • Yasir Hasan Siddique Aligarh Muslim University. Department of Zoology. Section of Genetics. Drosophila Transgenic Laboratory
  • Smita Jyoti Aligarh Muslim University. Department of Zoology. Section of Genetics. Drosophila Transgenic Laboratory
  • Falaq Naz Aligarh Muslim University. Department of Zoology. Section of Genetics. Drosophila Transgenic Laboratory

DOI:

https://doi.org/10.1590/s2175-97902018000317760

Keywords:

Luteolin, Parkinson’s disease, Drosophila, Oxidative stress

Abstract

In the present study we have studied the effect of 25, 50, 75 and 100 µM of luteolin on the transgenic Drosophila expressing human alpha synuclein. The doses of luteolin were established in diet and the PD flies were allowed to feed on it for 24 days. After 24 days of exposure the flies were assayed for climbing assay, oxidative stress markers, caspase-3 & 9 activity and dopamine content. The immunohistochemistry was also performed on the brain sections for the activity of tyrosine hydroxylase. The exposure of luteolin showed a dose dependent delay in the loss of climbing ability and activity, reduction in oxidative stress markers, caspase-3&9 activities and results in an increase in the dopamine content. The results obtained for the immunohistochemistry also supports the protective role of luteolin against the damage of the dopaminergic neurons.

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Published

2018-11-29

Issue

Section

Articles

How to Cite

Protective effect of luteolin on the transgenic Drosophila model of Parkinson’s disease. (2018). Brazilian Journal of Pharmaceutical Sciences, 54(3), e17760. https://doi.org/10.1590/s2175-97902018000317760