Antihypoxic activities of Crataegus pentaegyn and Crataegus microphylla fruits-an in vivo assay

Authors

  • Mohammad Ali Ebrahimzadeh Mazandaran University of Medical Sciences. School of Pharmacy. Pharmaceutical Sciences Research Center
  • Masoumeh Khalili Golestan University of Medical Sciences. Neuroscience Research Center
  • Negar Jafari Mazandaran University of Medical Sciences. School of Pharmacy. Pharmaceutical Sciences Research Center
  • Giti Zareh Mazandaran University of Medical Sciences. School of Pharmacy. Pharmaceutical Sciences Research Center
  • Davood Farzin Mazandaran University of Medical Sciences. School of Medicine. Department of Pharmacology
  • Gholamreza Amin Tehran University of Medical Sciences. Faculty of Pharmacy. Department of Pharmacognosy

DOI:

https://doi.org/10.1590/s2175-97902018000217363

Keywords:

Crataegus pentaegyna, Crataegus microphylla, Antihypoxia/evaluation, Circulatory hypoxia

Abstract

The aim of this study was to evaluate anti-hypoxia activity of polyphenolic extracts of Crataegus microphylla and Crataegus pentaegyn on mice. Three experimental models of hypoxia were considered, including asphyctic hypoxia, haemic hypoxia, and circulatory hypoxia. Polyphenolic extract of both plants exhibited significant anti-hypoxic activity and prolonged animal survival time. Anti-hypoia activity of C. pentaegyn was found to be superior to that of C. microphylla in circulatory and asphyctic hypoxia. Antihypoxic activity of these extracts may be attributed to their phenolic compounds.

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Published

2018-07-26

Issue

Vol. 54 No. 2 (2018)

Section

Articles

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Antihypoxic activities of Crataegus pentaegyn and Crataegus microphylla fruits-an in vivo assay. (2018). Brazilian Journal of Pharmaceutical Sciences, 54(2), e17363. https://doi.org/10.1590/s2175-97902018000217363