Kinetics study of hydrochlorothiazide lactose liquid state interaction using conventional isothermal arrhenius method under basic and neutral conditions

Authors

  • Faranak Ghaderi Urmia University of Medical Sciences; Department of Drug and Food Control
  • Mahboob Nemati Tabriz University of Medical Sciences; Department of Pharmaceutical and Food Control
  • Mohammad Reza Siahi-Shadbad Tabriz University of Medical Sciences; Drug Applied Research Center
  • Hadi Valizadeh Tabriz University of Medical Sciences; Department of Pharmaceutics
  • Farnaz Monajjemzadeh Tabriz University of Medical Sciences; Department of Pharmaceutical and Food Control

DOI:

https://doi.org/10.1590/s1984-82502016000400015

Abstract

The Maillard reaction of hydrochlorothiazide (HCTZ) and lactose has been previously demonstrated in pharmaceutical formulations. In this study, the activation energy of - hydrohlorothiazide and lactose interaction in the liquid state was ascertained under basic and neutral conditions. Conventional isothermal High Performance Liquid Chromatography (HPLC) technique was employed to ascertain the kinetic parameters using Arrhenius method. Results: The activation energy obtained was 82.43 and 100.28 kJ/mol under basic and neutral conditions, respectively. Consequently, it can be inferred that Maillard reaction is significantly affected by pH, which can be used as a control factor whenever the reaction potentially occurs.

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Published

2016-12-01

Issue

Vol. 52 No. 4 (2016)

Section

Articles

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Kinetics study of hydrochlorothiazide lactose liquid state interaction using conventional isothermal arrhenius method under basic and neutral conditions . (2016). Brazilian Journal of Pharmaceutical Sciences, 52(4), 709-714. https://doi.org/10.1590/s1984-82502016000400015