Mechanical properties and total hydroxycinnamic derivative release of starch/glycerol/Melissa officinalis extract films

Authors

  • Letícia Mello Rechia University of Southern Santa Catarina; TECFARMA
  • Juliana Bergman de Jesus Morona University of Southern Santa Catarina; TECFARMA
  • Karine Modolon Zepon University of Southern Santa Catarina; TECFARMA
  • Valdir Soldi Federal University of Santa Catarina; POLIMAT
  • Luiz Alberto Kanis University of Southern Santa Catarina; TECFARMA

DOI:

https://doi.org/10.1590/S1984-82502010000300012

Keywords:

Drugs^i1^sdelivery sys, Glycerol, Melissa officinalis, Herpes^i1^streatm, Polymeric film, Starch

Abstract

The aim of this study was to investigate the mechanical properties of starch/glycerol/Melissa officinalis, a topical drug delivery system for labial herpes treatment. Four films were prepared with different concentrations of starch, glycerol, and Melissa officinalis extract. The results revealed that increasing the glycerol concentration in the film reduced elasticity modulus and tensile strength, exhibiting a plasticizing effect. The increase in free volume resulted in increased release of hydroxycinnamic derivatives expressed as rosmarinic acid.

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Published

2010-09-01

Issue

Vol. 46 No. 3 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Mechanical properties and total hydroxycinnamic derivative release of starch/glycerol/Melissa officinalis extract films . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(3), 491-497. https://doi.org/10.1590/S1984-82502010000300012