Central activities of hydroalcoholic extract from Lafoensia pacari A. St.-Hil. stem bark

Authors

  • Pablinny Moreira Galdino Federal University of Goiás; Institute of Biological Sciences; Laboratory of Pharmacology of Natural Products
  • Marcus Vinícius Mariano Nascimento Federal University of Goiás; Institute of Biological Sciences; Laboratory of Pharmacology of Natural Products
  • Fábio Borges de Sousa Federal University of Goiás; Institute of Biological Sciences; Laboratory of Pharmacology of Natural Products
  • Reginaldo Nassar Ferreira Federal University of Goiás; Institute of Biological Sciences; Laboratory of Pharmacology of Natural Products
  • José Realino de Paula Federal University of Goiás; Pharmacy Faculty; Laboratory of Natural Products
  • Elson Alves Costa Federal University of Goiás; Institute of Biological Sciences; Laboratory of Pharmacology of Natural Products

DOI:

https://doi.org/10.1590/S1984-82502010000300008

Keywords:

Lafoensia pacari A. St.-Hil^i1^spharmacogn, Hydroalcoholic extract, Central Nervous System^i1^sexperimental st, Anxiety^i1^sexperimental st

Abstract

Lafoensia pacari A. St.-Hil. can be found from Amapá to Rio Grande do Sul states, and also in Paraguay and Bolivia. It is popularly known as pacari or mangava-brava and is used to promote weight loss, as an anti-thermal or tonic, to treat gastritis, ulcers, scarring, itching, discouragement, and cancer. In the open field tests, the hydroalcoholic extract from L. pacari stem bark (HEP) decreased the number of rearings, number of invaded squares, and increased immobility time compared to control animals. In the pentobarbital-induced sleep time test, HEP decreased latency time to sleep and increased sleeping time. In the rota-rod test, no changes in the studied parameters were observed. In the elevated plus maze, HEP increased the percentage time and percentage entries in the open arms, indicating that this extract exerts an anxiolytic-like activity.

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Published

2010-09-01

Issue

Vol. 46 No. 3 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

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How to Cite

Central activities of hydroalcoholic extract from Lafoensia pacari A. St.-Hil. stem bark . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(3), 455-462. https://doi.org/10.1590/S1984-82502010000300008