Prodrugs available on the Brazilian pharmaceutical market and their corresponding bioactivation pathways

Authors

  • Roberto Parise Filho Mackenzie Presbyterian University; Center for Health and Biological Sciences; Department of Pharmacy
  • Michelle Carneiro Polli São Francisco University; Department of Pharmacy
  • Silvio Barberato Filho Sorocaba University; Department of Pharmacy
  • Monique Garcia Mackenzie Presbyterian University; Center for Health and Biological Sciences; Department of Pharmacy
  • Elizabeth Igne Ferreira University of São Paulo; Faculty of Pharmaceutical Sciences; Department of Pharmacy

DOI:

https://doi.org/10.1590/S1984-82502010000300003

Keywords:

Prodrug design, Molecular modification, Drug development

Abstract

The aim of this paper was to emphasize the importance of prodrug design to therapy, by examining examples available on the Brazilian pharmaceutical market. The principles of prodrug design are briefly discussed herein. Examples of prodrugs from many important therapeutic classes are shown and their advantages relative to the drugs they are derived from are also discussed. Considering the importance of these therapeutic classes, from both therapy and economic standpoints, prodrug design is a very valuable aspect in the research of new drugs and for the pharmaceutical industry as a whole.

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Published

2010-09-01

Issue

Vol. 46 No. 3 (2010)

Section

Reviews

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Prodrugs available on the Brazilian pharmaceutical market and their corresponding bioactivation pathways . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(3), 393-420. https://doi.org/10.1590/S1984-82502010000300003