Chalcones and N-acylhydrazones: direct analogues? Exploratory data analysis applied to potential novel antileishmanial agents

Authors

  • Daniela Gonçalves Rando University of São Paulo; Faculty of Pharmaceutical Sciences; Department of Pharmacy; Laboratory of design and synthesis of chemotherapeutical agents potentially active against tropical diseases
  • Jeanine Giarolla University of São Paulo; Faculty of Pharmaceutical Sciences; Department of Pharmacy; Laboratory of design and synthesis of chemotherapeutical agents potentially active against tropical diseases
  • Kerly Fernanda Mesquita Pasqualoto University of São Paulo; Faculty of Pharmaceutical Sciences; Department of Pharmacy; Laboratory of design and synthesis of chemotherapeutical agents potentially active against tropical diseases
  • Elizabeth Igne Ferreira University of São Paulo; Faculty of Pharmaceutical Sciences; Department of Pharmacy; Laboratory of design and synthesis of chemotherapeutical agents potentially active against tropical diseases

DOI:

https://doi.org/10.1590/S1984-82502010000200019

Keywords:

Chalcones, N-acylhydrazones, Antileishmanial agents, Leishmaniasis, Chemometrics

Abstract

Leishmaniasis is an important health and social problem for which there is limited effective therapy. Chalcones and N-acylhydrazones have been studied as promising antileishmanial agents in enzymatic inhibition and in vitro assays. Since these chemical classes of compounds also resemble each other structurally, it would be useful to investigate whether they share direct analogy. Exploratory data analysis was applied to a library of chalcones and nitrated N-acylhydrazones assayed against Leishmania donovani to investigate their similarity. Under the conditions applied in the present study, the two classes did not present functional or structural analogy.

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Published

2010-06-01

Issue

Vol. 46 No. 2 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Chalcones and N-acylhydrazones: direct analogues? Exploratory data analysis applied to potential novel antileishmanial agents . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(2), 311-321. https://doi.org/10.1590/S1984-82502010000200019