Oxcarbazepine: validation and application of an analytical method

Authors

  • Paula Cristina Rezende Enéas Federal University of Minas Gerais; Faculty of Pharmacy; Department of Pharmaceutical Products
  • Renata Barbosa de Oliveira Federal University of Minas Gerais; Faculty of Pharmacy; Department of Pharmaceutical Products
  • Gerson Antônio Pianetti Federal University of Minas Gerais; Faculty of Pharmacy; Department of Pharmaceutical Products

DOI:

https://doi.org/10.1590/S1984-82502010000200013

Keywords:

Oxcarbazepine^i1^squantitative analy, Anticonvulsants^i1^squantitative analy, UV spectrophotometric^i1^smethod validat, Capsules^i1^sdissolut

Abstract

Oxcarbazepine (OXC) is an important anticonvulsant and mood stabilizing drug. A pharmacopoeial monograph for OXC is not yet available and therefore the development and validation of a new analytical method for quantification of this drug is essential. In the present study, a UV spectrophotometric method for the determination of OXC was developed. The various parameters, such as linearity, precision, accuracy and specificity, were studied according to International Conference on Harmonization Guidelines. Batches of 150 mg OXC capsules were prepared and analyzed using the validated UV method. The formulations were also evaluated for parameters including drug-excipient compatibility, flowability, uniformity of weight, disintegration time, assay, uniformity of content and the amount of drug dissolved during the first hour.

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Published

2010-06-01

Issue

Vol. 46 No. 2 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Oxcarbazepine: validation and application of an analytical method . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(2), 265-272. https://doi.org/10.1590/S1984-82502010000200013